Caspase 3 Orthologs
Aliases: caspase 3, Yama, apopain, procaspase3, PARP cleavage protease, cysteine protease CPP32, SREBP cleavage activity 1, caspase 3, apoptosis-related cysteine protease, CASP3, CPP32, CPP32B, SCA-1
Pfam Domain Structure
From CASP3 (human)
Members of the Caspase 3 ortholog set
| Human | Mouse | Rat | Chicken | Fly | Worm | |
| CMKB | CASP3 | Casp3 | Casp3 | CASP3 | - | - |
| Entrez Gene | 836 | 12367 | 25402 | 395476 | - | - |
| Uniprot | CASP3_HUMAN | CASP3_MOUSE | CASP3_RAT | - | - | - |
| OMIM | 600636 | - | - | - | - | - |
| Reagents | - | - | - | - | - | - |
| Results | 1 available | - | - | - | - | - |
References
- Cheng YJ, Lee CH, Lin YP, Huang JY, Su CC, Chang WT, Yang BC. Caspase-3 enhances lung metastasis and cell migration in a protease-independent mechanism through the ERK pathway. Int. J. Cancer 2008; 123:1278-85 (PubMed)
- Gdynia G, Grund K, Eckert A, Böck BC, Funke B, Macher-Goeppinger S, Sieber S, Herold-Mende C, Wiestler B, Wiestler OD, Roth W. Basal caspase activity promotes migration and invasiveness in glioblastoma cells. Mol. Cancer Res. 2007; 5:1232-40 (PubMed)
- Huang HS, Lee EY. Protein phosphatase-1 inhibitor-3 is an in vivo target of caspase-3 and participates in the apoptotic response. J. Biol. Chem. 2008; 283:18135-46 (PubMed)
Consortium Results & Data
Proteomics» Table 1. Identification and Quantitation of Proteins from Cell Body (CB) and Pseudopodium (PD) fractions
| IPI | Locus | Description | CB Spectra | CB peptide | PD Spectra | PD peptide | ratio |
| IPI00292140 | CASP3 | CASPASE-3 PRECURSOR. | 2 | 1 | 3 | 2 | 1.50 |
Consortium Related Products*
Biosensors » activity page
| Ortholog | Species | Name | Type | Source | Publications |
|---|---|---|---|---|---|
| Caspase 3 | none | Caspase-3 | Intramolecular FRET between FPs - GFP-Caspase-3 substrate-BFP |
-
|
Xu et al. |
| Caspase 3 | none | Caspase-3 | Intramolecular FRET between FPs - CFP-Caspase-3 substrate-Venus (improvement) |
-
|
Takemoto et al. |
* The resources presented here are largely those generated by the Consortium. The sidebar provides public databases that complement Consortium activities. For mice and biosensors, a public database is not available and therefore we have attempted to generate a migration related list for your convenience.