KIND2 Orthologs

Aliases: Kindlin-2, fermitin family homolog 2, mitogen inducible 2, pleckstrin homology domain containing, family C (with FERM domain) member 1, PLEKHC1, FERMT2, UNC112B, DKFZp686G11125, FLJ34213, FLJ44462, KIND2, MIG2, UNC112, mig-2

Pfam Domain Structure

From FERMT2 (human)

Members of the KIND2 ortholog set
Human Mouse Rat Chicken Fly Worm
CMKB FERMT2 Fermt2 Fermt2 PLEKHC1 Fit1 unc-112
Entrez Gene 10979 218952 289992 423589 38488 179972
Uniprot FERM2_HUMAN FERM2_MOUSE - - UN112_DROME UN112_CAEEL
OMIM 607746 - - - - -
Reagents - - - - - -
Results 2 available - - - 1 available 1 available
References
  1. Dowling JJ, Gibbs E, Russell M, Goldman D, Minarcik J, Golden JA, Feldman EL. Kindlin-2 is an essential component of intercalated discs and is required for vertebrate cardiac structure and function. Circ. Res. 2008; 102:423-31 (PubMed)
  2. Goult BT, Bouaouina M, Harburger DS, Bate N, Patel B, Anthis NJ, Campbell ID, Calderwood DA, Barsukov IL, Roberts GC, Critchley DR. The structure of the N-terminus of kindlin-1: a domain important for alphaiibbeta3 integrin activation. J. Mol. Biol. 2009; 394:944-56 (Full Text)
  3. Herz C, Aumailley M, Schulte C, Schlötzer-Schrehardt U, Bruckner-Tuderman L, Has C. Kindlin-1 is a phosphoprotein involved in regulation of polarity, proliferation, and motility of epidermal keratinocytes. J. Biol. Chem. 2006; 281:36082-90 (PubMed)
  4. Ussar S, Wang HV, Linder S, Fässler R, Moser M. The Kindlins: subcellular localization and expression during murine development. Exp. Cell Res. 2006; 312:3142-51 (PubMed)
Consortium Results & Data
Proteomics» Table 1. Identification and Quantitation of Proteins from Cell Body (CB) and Pseudopodium (PD) fractions
IPI Locus Description CB Spectra CB peptide PD Spectra PD peptide ratio
IPI00000856 PLEKHC1 SPLICE ISOFORM 1 OF PLECKSTRIN HOMOLOGY DOMAIN CONTAINING FAMILY C MEMBER 1. 36 14 62 19 1.72
Proteomics» Table 2. Proteins in major organelles and subcellular compartments
IPI Locus Description CB Spectra PD Spectra ratio Location
IPI00000856 PLEKHC1 SPLICE ISOFORM 1 OF PLECKSTRIN HOMOLOGY DOMAIN CONTAINING FAMILY C MEMBER 1. 36 62 1.72 cytoskeleton
Discovery» C. elegans genes affecting migration
Gene Description/Function Parental P0 defect Distribution1
(percent)
Progeny F1 defect Distribution2
(percent)
Express DTC Express BWM
Gene: unc‑112 (C47E8.7)
Gene Pair ID
CMKB
Entrez Gene
UNCoordinated
AhringerAutoClass: Cell Architecture
Function: Cell Architecture
InterPro: *Cell adhesion constituent
0.22 (N=110)
0.15 – 0.31
Type 1: 0
Type 2: 4
Type 3: 96
0.37 (N=30)
0.2 – 0.56
Type 1: 0
Type 2: 27
Type 3: 73
 
Yes
Discovery» wt-migratory_cells vs wt-non-migratory_cells
Symbol Description Median Values Fold Change Probe ID
CG14991
Flybase
Entrez
CMCKB
Fermitin 1 Mig: 188.1
Non-Mig: 158.1
1.18980 154757_at
Pathways

How many degrees of interaction?

Update
Legend: Legend for CMKB pathways