PAK2 Orthologs

Aliases: S6/H4 kinase, p21-activated kinase 2, p21 (CDKN1A)-activated kinase 2, PAK65, PAK2, PAKgamma

Pfam Domain Structure

From PAK2 (human)

Members of the PAK2 ortholog set
Human Mouse Rat Chicken Fly Worm
CMKB PAK2 Pak2 Pak2 PAK2 - -
Entrez Gene 5062 224105 29432 424860 - -
Uniprot PAK2_HUMAN PAK2_MOUSE PAK2_RAT - - -
OMIM 605022 - - - - -
Reagents - - - - - -
Results 3 available - - - - -
References
  1. Bokoch GM. Biology of the p21-activated kinases. Annu. Rev. Biochem. 2003; 72:743-81 (PubMed)
  2. Chew TL, Masaracchia RA, Goeckeler ZM, Wysolmerski RB. Phosphorylation of non-muscle myosin II regulatory light chain by p21-activated kinase (gamma-PAK). J. Muscle Res. Cell. Motil. 1998; 19:839-54 (PubMed)
  3. Cotteret S, Chernoff J. Pak GITs to Aurora-A. Dev. Cell 2005; 9:573-4 (PubMed)
  4. Dummler B, Ohshiro K, Kumar R, Field J. Pak protein kinases and their role in cancer. Cancer Metastasis Rev. 2009; 28:51-63 (PubMed)
  5. Fryer BH, Field J. Rho, Rac, Pak and angiogenesis: old roles and newly identified responsibilities in endothelial cells. Cancer Lett. 2005; 229:13-23 (PubMed)
  6. Gerthoffer WT. Actin cytoskeletal dynamics in smooth muscle contraction. Can. J. Physiol. Pharmacol. 2005; 83:851-6 (PubMed)
  7. Hoefen RJ, Berk BC. The multifunctional GIT family of proteins. J. Cell. Sci. 2006; 119:1469-75 (PubMed)
  8. Hofmann C, Shepelev M, Chernoff J. The genetics of Pak. J. Cell. Sci. 2004; 117:4343-54 (PubMed)
  9. Howe AK. Regulation of actin-based cell migration by cAMP/PKA. Biochim. Biophys. Acta 2004; 1692:159-74 (PubMed)
  10. Juliano RL, Reddig P, Alahari S, Edin M, Howe A, Aplin A. Integrin regulation of cell signalling and motility. Biochem. Soc. Trans. 2004; 32:443-6 (PubMed)
  11. Labruyère E, Guillén N. Host tissue invasion by Entamoeba histolytica is powered by motility and phagocytosis. Arch. Med. Res. 2006; 37:253-8 (PubMed)
  12. Manser E, Leung T, Salihuddin H, Zhao ZS, Lim L. A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature 1994; 367:40-6 (PubMed)
  13. Parrini MC, Matsuda M, de Gunzburg J. Spatiotemporal regulation of the Pak1 kinase. Biochem. Soc. Trans. 2005; 33:646-8 (PubMed)
  14. Settleman J. PAK-in' up cGMP for the move. Cell 2007; 128:237-8 (PubMed)
  15. Vlahou G, Rivero F. Rho GTPase signaling in Dictyostelium discoideum: insights from the genome. Eur. J. Cell Biol. 2006; 85:947-59 (PubMed)
  16. Zhao ZS, Manser E. PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulation. Biochem. J. 2005; 386:201-14 (Full Text)
Consortium Results & Data
Discovery» siRNA migration screen using a wound healing approach
Gene Description     MCF-10A phenotype     Secondary screen Wound Image Morphology Time-lapse
PAK2
Aliases: PAK65, PAKgamma
Entrez Gene: 5062
siRNA catalog
p21 (CDKN1A)-activated kinase 2
mRNA: NM_002577
Library: Kinase
Classification: Tyr Kinase
Final bin: No Phenotype
SMARTpool bin: No change
Avg area: 1.81
Avg Alamar: 0.85
Knockdown %: 80-90
  PAK2
Link
PAK2
Link
 
Discovery» siRNA Focal Adhesion Phenotypes
Gene Description High-Res Montage
PAK2
Aliases: PAK65, PAKgamma
Entrez Gene: 5062
siRNA catalog
p21 (CDKN1A)-activated kinase 2
mRNA: NM_002577
Library: Kinase
PAK2
Link
PAK2
Link
Proteomics» Table 1. Identification and Quantitation of Proteins from Cell Body (CB) and Pseudopodium (PD) fractions
IPI Locus Description CB Spectra CB peptide PD Spectra PD peptide ratio
IPI00419979 PAK2 PAK2 PROTEIN. 28 12 56 18 2.00