ITGB3 Orthologs

Aliases: Platelet membrane glycoprotein IIIa, integrin beta chain, beta 3, platelet glycoprotein IIIa, CD61, ITGB3, GP3A, GPIIIa

Pfam Domain Structure

From ITGB3 (human)

Members of the ITGB3 ortholog set
Human Mouse Rat Chicken Fly Worm
CMKB ITGB3 Itgb3 - - - -
Entrez Gene 3690 16416 - - - -
Uniprot ITB3_HUMAN ITB3_MOUSE - - - -
OMIM 173470 - - - - -
Reagents - 2 available - - - -
Results 3 available - - - - -
References
  1. Brakebusch C, Fässler R. beta 1 integrin function in vivo: adhesion, migration and more. Cancer Metastasis Rev. 2005; 24:403-11 (PubMed)
  2. Caswell PT, Vadrevu S, Norman JC. Integrins: masters and slaves of endocytic transport. Nat. Rev. Mol. Cell Biol. 2009; 10:843-53 (PubMed)
  3. Delon I, Brown NH. Integrins and the actin cytoskeleton. Curr. Opin. Cell Biol. 2007; 19:43-50 (PubMed)
  4. Humphries JD, Byron A, Humphries MJ. Integrin ligands at a glance. J. Cell. Sci. 2006; 119:3901-3 (PubMed)
  5. Hynes RO. Integrins: bidirectional, allosteric signaling machines. Cell 2002; 110:673-87 (PubMed)
  6. Kim M, Carman CV, Springer TA. Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins. Science 2003; 301:1720-5 (PubMed)
  7. Luo BH, Carman CV, Springer TA. Structural basis of integrin regulation and signaling. Annu. Rev. Immunol. 2007; 25:619-47 (Full Text)
  8. Niu JX, Zhang WJ, Ye LY, Wu LQ, Zhu GJ, Yang ZH, Grau GE, Lou JN. The role of adhesion molecules, alpha v beta 3, alpha v beta 5 and their ligands in the tumor cell and endothelial cell adhesion. Eur. J. Cancer Prev. 2007; 16:517-27 (PubMed)
  9. Otey CA, Pavalko FM, Burridge K. An interaction between alpha-actinin and the beta 1 integrin subunit in vitro. J. Cell Biol. 1990; 111:721-9 (Full Text)
  10. Pfaff M, Liu S, Erle DJ, Ginsberg MH. Integrin beta cytoplasmic domains differentially bind to cytoskeletal proteins. J. Biol. Chem. 1998; 273:6104-9 (PubMed)
  11. Thodeti CK, Fröhlich C, Nielsen CK, Takada Y, Fässler R, Albrechtsen R, Wewer UM. ADAM12-mediated focal adhesion formation is differently regulated by beta1 and beta3 integrins. FEBS Lett. 2005; 579:5589-95 (PubMed)
  12. Vicente-Manzanares M, Choi CK, Horwitz AR. Integrins in cell migration--the actin connection. J. Cell. Sci. 2009; 122:199-206 (Full Text)
  13. Wegener KL, Partridge AW, Han J, Pickford AR, Liddington RC, Ginsberg MH, Campbell ID. Structural basis of integrin activation by talin. Cell 2007; 128:171-82 (PubMed)
  14. Wiesner S, Legate KR, Fässler R. Integrin-actin interactions. Cell. Mol. Life Sci. 2005; 62:1081-99 (PubMed)
  15. Zaidel-Bar R, Geiger B. The switchable integrin adhesome. J. Cell. Sci. 2010; 123:1385-8 (Full Text)
  16. Zaidel-Bar R, Itzkovitz S, Ma'ayan A, Iyengar R, Geiger B. Functional atlas of the integrin adhesome. Nat. Cell Biol. 2007; 9:858-67 (Full Text)
Consortium Results & Data
Results & Data
Ortholog Species Type Description Method Status Source Publications
ITGB3 none structure

Beta tails as an interaction hub

NMR

completed Campbell Oxley et al.
ITGB3 none structure

Beta 3-Src SH3

NMR

completed Campbell
-
ITGB3 none structure

Talin -beta3 integrin

X-Ray crystallography, NMR

data available Liddington García-Alvarez et al., Wegener et al., Calderwood et al.
Discovery» siRNA migration screen using a wound healing approach
Gene Description     MCF-10A phenotype     Secondary screen Wound Image Morphology Time-lapse
ITGB3
Aliases: CD61, GP3A, GPIIIa
Entrez Gene: 3690
siRNA catalog
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
mRNA: NM_000212
Library: MAR
Classification: integrin
Focal Adhesion Related: Yes
Final bin: Discordant
SMARTpool bin: Low Alamar
Avg area: 2.11
Avg Alamar: 0.78
Knockdown %: not done
ERBB2: No Change
BCL2: Low Alamar
ITGB3
Link
ITGB3
Link
 
Discovery» siRNA Focal Adhesion Phenotypes
Gene Description High-Res Montage
ITGB3
Aliases: CD61, GP3A, GPIIIa
Entrez Gene: 3690
siRNA catalog
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
mRNA: NM_000212
Library: MAR
ITGB3
Link
ITGB3
Link
Proteomics» Table 1. Identification and Quantitation of Proteins from Cell Body (CB) and Pseudopodium (PD) fractions
IPI Locus Description CB Spectra CB peptide PD Spectra PD peptide ratio
IPI00303283 ITGB3 SPLICE ISOFORM BETA-3A OF INTEGRIN BETA-3 PRECURSOR. 0 0 3 1 PDU
Consortium Related Products*
Mice » activity page
Ortholog Species Name Method Phenotype Status Jax Availability Source Publications
ITGB3 mouse Beta-3 integrin Y747A Targeted - knockin
-
completed - mouse available
-
Ginsberg Petrich et al.
ITGB3 mouse Beta-3 integrin L746A Targeted - knockin
-
completed - mouse available
-
Ginsberg Petrich et al.

* The resources presented here are largely those generated by the Consortium. The sidebar provides public databases that complement Consortium activities. For mice and biosensors, a public database is not available and therefore we have attempted to generate a migration related list for your convenience.