ABL1 Orthologs

Aliases: proto-oncogene tyrosine-protein kinase ABL1, Abelson murine leukemia viral oncogene homolog 1, v-abl Abelson murine leukemia viral oncogene homolog 1, bcr/c-abl oncogene protein, Abelson murine leukemia viral (v-abl) oncogene homolog 1, ABL, ABL1, RP11-83J21.1, bcr/abl, JTK7, p150, c-ABL, v-abl

Pfam Domain Structure

From ABL1 (human)

Members of the ABL1 ortholog set
Human Mouse Rat Chicken Fly Worm
CMKB ABL1 Abl1 Abl1 ABL1 Abl -
Entrez Gene 25 11350 311860 417181 45821 -
Uniprot ABL1_HUMAN ABL1_MOUSE - - ABL_DROME -
OMIM 189980 - - - - -
Reagents - 5 available - - - -
Results 2 available - - - 2 available -
References
  1. Arlinghaus R, Sun T. Signal transduction pathways in Bcr-Abl transformed cells. Cancer Treat. Res. 2004; 119:239-70 (PubMed)
  2. Era T. Bcr-Abl is a "molecular switch" for the decision for growth and differentiation in hematopoietic stem cells. Int. J. Hematol. 2002; 76:35-43 (PubMed)
  3. Hantschel O, Superti-Furga G. Regulation of the c-Abl and Bcr-Abl tyrosine kinases. Nat. Rev. Mol. Cell Biol. 2004; 5:33-44 (PubMed)
  4. Hernández SE, Krishnaswami M, Miller AL, Koleske AJ. How do Abl family kinases regulate cell shape and movement?. Trends Cell Biol. 2004; 14:36-44 (PubMed)
  5. Kharas MG, Fruman DA. ABL oncogenes and phosphoinositide 3-kinase: mechanism of activation and downstream effectors. Cancer Res. 2005; 65:2047-53 (PubMed)
  6. Pendergast AM. The Abl family kinases: mechanisms of regulation and signaling. Adv. Cancer Res. 2002; 85:51-100 (PubMed)
  7. Redig AJ, Vakana E, Platanias LC. Regulation of mammalian target of rapamycin and mitogen activated protein kinase pathways by BCR-ABL. Leuk. Lymphoma 2011; 52 Suppl 1:45-53 (PubMed)
  8. Reiter A, Walz C, Cross NC. Tyrosine kinases as therapeutic targets in BCR-ABL negative chronic myeloproliferative disorders. Curr Drug Targets 2007; 8:205-16 (PubMed)
  9. Saglio G, Cilloni D. Abl: the prototype of oncogenic fusion proteins. Cell. Mol. Life Sci. 2004; 61:2897-911 (PubMed)
  10. Steelman LS, Pohnert SC, Shelton JG, Franklin RA, Bertrand FE, McCubrey JA. JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis. Leukemia 2004; 18:189-218 (PubMed)
  11. Wang JY. Controlling Abl: auto-inhibition and co-inhibition?. Nat. Cell Biol. 2004; 6:3-7 (PubMed)
  12. Wong S, Witte ON. The BCR-ABL story: bench to bedside and back. Annu. Rev. Immunol. 2004; 22:247-306 (PubMed)
  13. Zhu J, Wang JY. Death by Abl: a matter of location. Curr. Top. Dev. Biol. 2004; 59:165-92 (PubMed)
Consortium Results & Data
Discovery» siRNA migration screen using a wound healing approach
Gene Description     MCF-10A phenotype     Secondary screen Wound Image Morphology Time-lapse
ABL1
Aliases: ABL, JTK7, p150, c-ABL, v-abl, bcr/abl
Entrez Gene: 25
siRNA catalog
v-abl Abelson murine leukemia viral oncogene homolog 1
mRNA: NM_007313
Library: Kinase
Classification: Tyr Kinase
Focal Adhesion Related: Yes
Final bin: Discordant
SMARTpool bin: Impaired *
Avg area: 1.98
Avg Alamar: 0.90
Knockdown %: 60-70
ERBB2: No Change
ABL1
Link
ABL1
Link
 
Discovery» siRNA Focal Adhesion Phenotypes
Gene Description High-Res Montage
ABL1
Aliases: ABL, JTK7, p150, c-ABL, v-abl, bcr/abl
Entrez Gene: 25
siRNA catalog
v-abl Abelson murine leukemia viral oncogene homolog 1
mRNA: NM_007313
Library: Kinase
ABL1
Link
ABL1
Link
Discovery» Drosophila Migration Genes
Gene Name Function Cell
Type
Phenotypes Reagents/
Alleles
Reference
abl
Entrez: CG4032
Flybase: FBgn0000017
Abl tyrosine kinase tyrosine kinase dorsal closure Loss of function: disrupts cell migration and cell shape; Supressor of the Bsk phenotype

Comments: Antibody available from Rubbin
ablMZ Grevengoed et al., 2001
Discovery» Drosophila Morphology Genes
Gene Name Cell Count/
Normalization
Stellate11
NumCorners
Stellate22
Binsum6
Non-Spreading3
CG4032
Entrez Gene: 45821
Abl tyrosine kinase
Aliases: abl kinase; abelson; D-abelson; Abelson; Abelson Kinase; Abl oncogene; Abelson tyrosine kinase
10.625
0.786
0.67 0.844 Actin: 1.018
Area: 1.072
Ratio: 0.950
Consortium Related Products*
Mice » activity page
Ortholog Species Name Method Phenotype Status Jax Availability Source Publications
ABL1 mouse Abl / Arg - double knockout in neuroepithelial cells
-
Alterations in actin cytoskeleton. completed
-
-
Koleske et al.
ABL1 mouse Abl
-
Defect in spermatogenesis. completed
-
-
Kharbanda et al.
ABL1 mouse Abl
-
Perinatal mortality, runtedness, and abnormal spleen, thymus, head, and eye development. completed
-
-
Schwartzberg et al., Tybulewicz et al.
ABL1 mouse Abl
-
Abl-/- mice that survive to adulthood have low levels of mature B and T cells. completed
-
-
Hardin et al.
ABL1 mouse Abl / Arg - double
-
Die E11 - neurulation defects. completed
-
-
Koleske et al.
Biosensors » activity page
Ortholog Species Name Type Source Publications
ABL1 none Abl kinase Chelation-enhanced fluorophore Imperiali Shults and Imperiali

* The resources presented here are largely those generated by the Consortium. The sidebar provides public databases that complement Consortium activities. For mice and biosensors, a public database is not available and therefore we have attempted to generate a migration related list for your convenience.

Pathways

How many degrees of interaction?

Update
Legend: Legend for CMKB pathways