ABL1 Orthologs
Aliases: proto-oncogene tyrosine-protein kinase ABL1, Abelson murine leukemia viral oncogene homolog 1, v-abl Abelson murine leukemia viral oncogene homolog 1, bcr/c-abl oncogene protein, Abelson murine leukemia viral (v-abl) oncogene homolog 1, ABL, ABL1, RP11-83J21.1, bcr/abl, JTK7, p150, c-ABL, v-abl
Pfam Domain Structure
From ABL1 (human)
Members of the ABL1 ortholog set
| Human | Mouse | Rat | Chicken | Fly | Worm | |
| CMKB | ABL1 | Abl1 | Abl1 | ABL1 | Abl | - |
| Entrez Gene | 25 | 11350 | 311860 | 417181 | 45821 | - |
| Uniprot | ABL1_HUMAN | ABL1_MOUSE | - | - | ABL_DROME | - |
| OMIM | 189980 | - | - | - | - | - |
| Reagents | - | 5 available | - | - | - | - |
| Results | 2 available | - | - | - | 2 available | - |
References
- Arlinghaus R, Sun T. Signal transduction pathways in Bcr-Abl transformed cells. Cancer Treat. Res. 2004; 119:239-70 (PubMed)
- Era T. Bcr-Abl is a "molecular switch" for the decision for growth and differentiation in hematopoietic stem cells. Int. J. Hematol. 2002; 76:35-43 (PubMed)
- Hantschel O, Superti-Furga G. Regulation of the c-Abl and Bcr-Abl tyrosine kinases. Nat. Rev. Mol. Cell Biol. 2004; 5:33-44 (PubMed)
- Hernández SE, Krishnaswami M, Miller AL, Koleske AJ. How do Abl family kinases regulate cell shape and movement?. Trends Cell Biol. 2004; 14:36-44 (PubMed)
- Kharas MG, Fruman DA. ABL oncogenes and phosphoinositide 3-kinase: mechanism of activation and downstream effectors. Cancer Res. 2005; 65:2047-53 (PubMed)
- Pendergast AM. The Abl family kinases: mechanisms of regulation and signaling. Adv. Cancer Res. 2002; 85:51-100 (PubMed)
- Redig AJ, Vakana E, Platanias LC. Regulation of mammalian target of rapamycin and mitogen activated protein kinase pathways by BCR-ABL. Leuk. Lymphoma 2011; 52 Suppl 1:45-53 (PubMed)
- Reiter A, Walz C, Cross NC. Tyrosine kinases as therapeutic targets in BCR-ABL negative chronic myeloproliferative disorders. Curr Drug Targets 2007; 8:205-16 (PubMed)
- Saglio G, Cilloni D. Abl: the prototype of oncogenic fusion proteins. Cell. Mol. Life Sci. 2004; 61:2897-911 (PubMed)
- Steelman LS, Pohnert SC, Shelton JG, Franklin RA, Bertrand FE, McCubrey JA. JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis. Leukemia 2004; 18:189-218 (PubMed)
- Wang JY. Controlling Abl: auto-inhibition and co-inhibition?. Nat. Cell Biol. 2004; 6:3-7 (PubMed)
- Wong S, Witte ON. The BCR-ABL story: bench to bedside and back. Annu. Rev. Immunol. 2004; 22:247-306 (PubMed)
- Zhu J, Wang JY. Death by Abl: a matter of location. Curr. Top. Dev. Biol. 2004; 59:165-92 (PubMed)
Consortium Results & Data
Discovery» siRNA migration screen using a wound healing approach
| Gene | Description | MCF-10A phenotype | Secondary screen | Wound Image | Morphology | Time-lapse |
|
ABL1 Aliases: ABL, JTK7, p150, c-ABL, v-abl, bcr/abl Entrez Gene: 25 siRNA catalog |
v-abl Abelson murine leukemia viral oncogene homolog 1 mRNA: NM_007313 Library: Kinase Classification: Tyr Kinase Focal Adhesion Related: Yes |
Final bin: Discordant SMARTpool bin: Impaired * Avg area: 1.98 Avg Alamar: 0.90 Knockdown %: 60-70 |
ERBB2: No Change |
 Link |
 Link |
Discovery» siRNA Focal Adhesion Phenotypes
| Gene | Description | High-Res | Montage |
|
ABL1 Aliases: ABL, JTK7, p150, c-ABL, v-abl, bcr/abl Entrez Gene: 25 siRNA catalog |
v-abl Abelson murine leukemia viral oncogene homolog 1 mRNA: NM_007313 Library: Kinase |
 Link |
 Link |
Discovery» Drosophila Migration Genes
| Gene | Name | Function |
Cell Type |
Phenotypes |
Reagents/ Alleles |
Reference |
|
abl Entrez: CG4032 Flybase: FBgn0000017 |
Abl tyrosine kinase | tyrosine kinase | dorsal closure |
Loss of function: disrupts cell migration and cell shape; Supressor of the Bsk phenotype Comments: Antibody available from Rubbin |
ablMZ | Grevengoed et al., 2001 |
Discovery» Drosophila Morphology Genes
| Gene | Name |
Cell Count/ Normalization |
Stellate11 NumCorners |
Stellate22 Binsum6 |
Non-Spreading3 | |
|
CG4032 Entrez Gene: 45821 |
Abl tyrosine kinase Aliases: abl kinase; abelson; D-abelson; Abelson; Abelson Kinase; Abl oncogene; Abelson tyrosine kinase |
10.625 0.786 |
0.67 | 0.844 |
Actin: 1.018 Area: 1.072 Ratio: 0.950 |
|
Consortium Related Products*
Mice » activity page
| Ortholog | Species | Name | Method | Phenotype | Status | Jax Availability | Source | Publications |
|---|---|---|---|---|---|---|---|---|
| ABL1 | mouse | Abl / Arg - double knockout in neuroepithelial cells | - |
Alterations in actin cytoskeleton. | completed |
-
|
-
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Koleske et al. |
| ABL1 | mouse | Abl | - |
Defect in spermatogenesis. | completed |
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|
-
|
Kharbanda et al. |
| ABL1 | mouse | Abl | - |
Perinatal mortality, runtedness, and abnormal spleen, thymus, head, and eye development. | completed |
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-
|
Schwartzberg et al., Tybulewicz et al. |
| ABL1 | mouse | Abl | - |
Abl-/- mice that survive to adulthood have low levels of mature B and T cells. | completed |
-
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-
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Hardin et al. |
| ABL1 | mouse | Abl / Arg - double | - |
Die E11 - neurulation defects. | completed |
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-
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Koleske et al. |
Biosensors » activity page
| Ortholog | Species | Name | Type | Source | Publications |
|---|---|---|---|---|---|
| ABL1 | none | Abl kinase | Chelation-enhanced fluorophore | Imperiali | Shults and Imperiali |
* The resources presented here are largely those generated by the Consortium. The sidebar provides public databases that complement Consortium activities. For mice and biosensors, a public database is not available and therefore we have attempted to generate a migration related list for your convenience.
Pathways