ABL2 Orthologs

Aliases: Abelson murine leukemia viral oncogene homolog 2, Abelson-related gene protein, Tyrosine kinase ARG, v-abl Abelson murine leukemia viral oncogene homolog 2, Abelson-related, Abelson murine leukemia viral (v-abl) oncogene homolog 2, RP11-177A2.3, FLJ41441, ABL2, ARG, FLJ22224, FLJ31718, ABLL

Pfam Domain Structure

From ABL2 (human)

Members of the ABL2 ortholog set
Human Mouse Rat Chicken Fly Worm
CMKB ABL2 Abl2 Abl2 - - -
Entrez Gene 27 11352 304883 - - -
Uniprot ABL2_HUMAN ABL2_MOUSE - - - -
OMIM 164690 - - - - -
Reagents - 2 available - - - -
Results 4 available - - - - -
References
  1. Arlinghaus R, Sun T. Signal transduction pathways in Bcr-Abl transformed cells. Cancer Treat. Res. 2004; 119:239-70 (PubMed)
  2. Era T. Bcr-Abl is a "molecular switch" for the decision for growth and differentiation in hematopoietic stem cells. Int. J. Hematol. 2002; 76:35-43 (PubMed)
  3. Hantschel O, Superti-Furga G. Regulation of the c-Abl and Bcr-Abl tyrosine kinases. Nat. Rev. Mol. Cell Biol. 2004; 5:33-44 (PubMed)
  4. Hernández SE, Krishnaswami M, Miller AL, Koleske AJ. How do Abl family kinases regulate cell shape and movement?. Trends Cell Biol. 2004; 14:36-44 (PubMed)
  5. Kharas MG, Fruman DA. ABL oncogenes and phosphoinositide 3-kinase: mechanism of activation and downstream effectors. Cancer Res. 2005; 65:2047-53 (PubMed)
  6. Pendergast AM. The Abl family kinases: mechanisms of regulation and signaling. Adv. Cancer Res. 2002; 85:51-100 (PubMed)
  7. Redig AJ, Vakana E, Platanias LC. Regulation of mammalian target of rapamycin and mitogen activated protein kinase pathways by BCR-ABL. Leuk. Lymphoma 2011; 52 Suppl 1:45-53 (PubMed)
  8. Reiter A, Walz C, Cross NC. Tyrosine kinases as therapeutic targets in BCR-ABL negative chronic myeloproliferative disorders. Curr Drug Targets 2007; 8:205-16 (PubMed)
  9. Saglio G, Cilloni D. Abl: the prototype of oncogenic fusion proteins. Cell. Mol. Life Sci. 2004; 61:2897-911 (PubMed)
  10. Steelman LS, Pohnert SC, Shelton JG, Franklin RA, Bertrand FE, McCubrey JA. JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis. Leukemia 2004; 18:189-218 (PubMed)
  11. Wang JY. Controlling Abl: auto-inhibition and co-inhibition?. Nat. Cell Biol. 2004; 6:3-7 (PubMed)
  12. Wong S, Witte ON. The BCR-ABL story: bench to bedside and back. Annu. Rev. Immunol. 2004; 22:247-306 (PubMed)
  13. Zhu J, Wang JY. Death by Abl: a matter of location. Curr. Top. Dev. Biol. 2004; 59:165-92 (PubMed)
Consortium Results & Data

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Consortium Related Products*
Mice » activity page
Ortholog Species Name Method Phenotype Status Jax Availability Source Publications
ABL2 mouse Abl / Arg - double knockout in neuroepithelial cells
-
Alterations in actin cytoskeleton. completed
-
-
Koleske et al.
ABL2 mouse Abl / Arg - double
-
Die E11 - neurulation defects. completed
-
-
Koleske et al.
Biosensors » activity page
Ortholog Species Name Type Source Publications
ABL2 none Abl - (SH2 domain) Environment sensitive fluorophore Imperiali Vázquez et al.

* The resources presented here are largely those generated by the Consortium. The sidebar provides public databases that complement Consortium activities. For mice and biosensors, a public database is not available and therefore we have attempted to generate a migration related list for your convenience.