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ABL2 Orthologs

Aliases: Abelson murine leukemia viral oncogene homolog 2, Abelson-related gene protein, Tyrosine kinase ARG, v-abl Abelson murine leukemia viral oncogene homolog 2, Abelson-related, Abelson murine leukemia viral (v-abl) oncogene homolog 2, RP11-177A2.3, FLJ41441, ABL2, ARG, FLJ22224, FLJ31718, ABLL

Pfam Domain Structure

From ABL2 (human)

Members of the ABL2 ortholog set
Human Mouse Rat Chicken Fly Worm
CMKB ABL2 Abl2 Abl2 - - -
Entrez Gene 27 11352 304883 - - -
Uniprot ABL2_HUMAN ABL2_MOUSE - - - -
OMIM 164690 - - - - -
Reagents - 2 available - - - -
Results 4 available - - - - -
References
  1. Arlinghaus R, Sun T. Signal transduction pathways in Bcr-Abl transformed cells. Cancer Treat. Res. 2004; 119:239-70 (PubMed)
  2. Era T. Bcr-Abl is a "molecular switch" for the decision for growth and differentiation in hematopoietic stem cells. Int. J. Hematol. 2002; 76:35-43 (PubMed)
  3. Hantschel O, Superti-Furga G. Regulation of the c-Abl and Bcr-Abl tyrosine kinases. Nat. Rev. Mol. Cell Biol. 2004; 5:33-44 (PubMed)
  4. Hernández SE, Krishnaswami M, Miller AL, Koleske AJ. How do Abl family kinases regulate cell shape and movement?. Trends Cell Biol. 2004; 14:36-44 (PubMed)
  5. Kharas MG, Fruman DA. ABL oncogenes and phosphoinositide 3-kinase: mechanism of activation and downstream effectors. Cancer Res. 2005; 65:2047-53 (PubMed)
  6. Pendergast AM. The Abl family kinases: mechanisms of regulation and signaling. Adv. Cancer Res. 2002; 85:51-100 (PubMed)
  7. Redig AJ, Vakana E, Platanias LC. Regulation of mammalian target of rapamycin and mitogen activated protein kinase pathways by BCR-ABL. Leuk. Lymphoma 2011; 52 Suppl 1:45-53 (PubMed)
  8. Reiter A, Walz C, Cross NC. Tyrosine kinases as therapeutic targets in BCR-ABL negative chronic myeloproliferative disorders. Curr Drug Targets 2007; 8:205-16 (PubMed)
  9. Saglio G, Cilloni D. Abl: the prototype of oncogenic fusion proteins. Cell. Mol. Life Sci. 2004; 61:2897-911 (PubMed)
  10. Steelman LS, Pohnert SC, Shelton JG, Franklin RA, Bertrand FE, McCubrey JA. JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis. Leukemia 2004; 18:189-218 (PubMed)
  11. Wang JY. Controlling Abl: auto-inhibition and co-inhibition?. Nat. Cell Biol. 2004; 6:3-7 (PubMed)
  12. Wong S, Witte ON. The BCR-ABL story: bench to bedside and back. Annu. Rev. Immunol. 2004; 22:247-306 (PubMed)
  13. Zhu J, Wang JY. Death by Abl: a matter of location. Curr. Top. Dev. Biol. 2004; 59:165-92 (PubMed)
Consortium Results & Data
Discovery» siRNA migration screen using a wound healing approach
Gene Description     MCF-10A phenotype     Secondary screen Wound Image Morphology Time-lapse
ABL2
Aliases: ARG, ABLL
Entrez Gene: 27
siRNA catalog 		v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)
mRNA: NM_005158
Library: Kinase
Classification: Tyr Kinase
 Final bin: No Phenotype
SMARTpool bin: No change
Avg area: 1.27
Avg Alamar: 0.98
Knockdown %: 60-70
   ABL2
Link 		ABL2
Link 		 
Discovery» siRNA Focal Adhesion Phenotypes
Gene Description High-Res Montage
ABL2
Aliases: ARG, ABLL
Entrez Gene: 27
siRNA catalog 		v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)
mRNA: NM_005158
Library: Kinase
 ABL2
Link 		ABL2
Link
Proteomics» Table 1. Identification and Quantitation of Proteins from Cell Body (CB) and Pseudopodium (PD) fractions
IPI Locus Description CB Spectra CB peptide PD Spectra PD peptide ratio
IPI00329488 ABL2 SPLICE ISOFORM IB OF TYROSINE-PROTEIN KINASE ABL2. 2 1 2 2 1.00
Proteomics» Table 2. Proteins in major organelles and subcellular compartments
IPI Locus Description CB Spectra PD Spectra ratio Location
IPI00329488 ABL2 SPLICE ISOFORM IB OF TYROSINE-PROTEIN KINASE ABL2. 2 2 1 cytoskeleton
IPI00329488 ABL2 SPLICE ISOFORM IB OF TYROSINE-PROTEIN KINASE ABL2. 2 2 1 cytosol
Consortium Related Products*
Mice » activity page
Ortholog Species Name Method Phenotype Status Jax Availability Source Publications
ABL2 mouse Abl / Arg - double knockout in neuroepithelial cells
-
 Alterations in actin cytoskeleton. completed
-
-
 Koleske et al.
ABL2 mouse Abl / Arg - double
-
 Die E11 - neurulation defects. completed
-
-
 Koleske et al.
Biosensors » activity page
Ortholog Species Name Type Source Publications
ABL2 none Abl - (SH2 domain) Environment sensitive fluorophore Imperiali Vázquez et al.

* The resources presented here are largely those generated by the Consortium. The sidebar provides public databases that complement Consortium activities. For mice and biosensors, a public database is not available and therefore we have attempted to generate a migration related list for your convenience.