PAK3 Orthologs

Aliases: p21-activated kinase 3, beta-PAK, p21 (CDKN1A)-activated kinase 3, serine/threonine-protein kinase PAK 3, oligophrenin-3, p21-activated kinase-3, bPAK, PAK-3, PAK3, RP5-914P14.3, MRX47, MRX30, OPHN3, hPAK3, CDKN1A, PAK3beta

Pfam Domain Structure

From PAK3 (human)

Members of the PAK3 ortholog set
Human Mouse Rat Chicken Fly Worm
CMKB PAK3 Pak3 Pak3 PAK3 - -
Entrez Gene 5063 18481 29433 422342 - -
Uniprot PAK3_HUMAN PAK3_MOUSE PAK3_RAT - - -
OMIM 300142 - - - - -
Reagents - - - - - -
Results 2 available - - - - -
References
  1. Bokoch GM. Biology of the p21-activated kinases. Annu. Rev. Biochem. 2003; 72:743-81 (PubMed)
  2. Chew TL, Masaracchia RA, Goeckeler ZM, Wysolmerski RB. Phosphorylation of non-muscle myosin II regulatory light chain by p21-activated kinase (gamma-PAK). J. Muscle Res. Cell. Motil. 1998; 19:839-54 (PubMed)
  3. Cotteret S, Chernoff J. Pak GITs to Aurora-A. Dev. Cell 2005; 9:573-4 (PubMed)
  4. Dummler B, Ohshiro K, Kumar R, Field J. Pak protein kinases and their role in cancer. Cancer Metastasis Rev. 2009; 28:51-63 (PubMed)
  5. Fryer BH, Field J. Rho, Rac, Pak and angiogenesis: old roles and newly identified responsibilities in endothelial cells. Cancer Lett. 2005; 229:13-23 (PubMed)
  6. Gerthoffer WT. Actin cytoskeletal dynamics in smooth muscle contraction. Can. J. Physiol. Pharmacol. 2005; 83:851-6 (PubMed)
  7. Hoefen RJ, Berk BC. The multifunctional GIT family of proteins. J. Cell. Sci. 2006; 119:1469-75 (PubMed)
  8. Hofmann C, Shepelev M, Chernoff J. The genetics of Pak. J. Cell. Sci. 2004; 117:4343-54 (PubMed)
  9. Howe AK. Regulation of actin-based cell migration by cAMP/PKA. Biochim. Biophys. Acta 2004; 1692:159-74 (PubMed)
  10. Juliano RL, Reddig P, Alahari S, Edin M, Howe A, Aplin A. Integrin regulation of cell signalling and motility. Biochem. Soc. Trans. 2004; 32:443-6 (PubMed)
  11. Labruyère E, Guillén N. Host tissue invasion by Entamoeba histolytica is powered by motility and phagocytosis. Arch. Med. Res. 2006; 37:253-8 (PubMed)
  12. Manser E, Leung T, Salihuddin H, Zhao ZS, Lim L. A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature 1994; 367:40-6 (PubMed)
  13. Parrini MC, Matsuda M, de Gunzburg J. Spatiotemporal regulation of the Pak1 kinase. Biochem. Soc. Trans. 2005; 33:646-8 (PubMed)
  14. Settleman J. PAK-in' up cGMP for the move. Cell 2007; 128:237-8 (PubMed)
  15. Vlahou G, Rivero F. Rho GTPase signaling in Dictyostelium discoideum: insights from the genome. Eur. J. Cell Biol. 2006; 85:947-59 (PubMed)
  16. Zhao ZS, Manser E. PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulation. Biochem. J. 2005; 386:201-14 (Full Text)
Consortium Results & Data
Discovery» siRNA migration screen using a wound healing approach
Gene Description     MCF-10A phenotype     Secondary screen Wound Image Morphology Time-lapse
PAK3
Aliases: bPAK, MRX30, MRX47, OPHN3, hPAK3, CDKN1A, PAK3beta
Entrez Gene: 5063
siRNA catalog
p21 (CDKN1A)-activated kinase 3
mRNA: NM_002578
Library: Kinase
Classification: Ser/Thr Kinase
Final bin: No Phenotype
SMARTpool bin: No change
Avg area: 1.62
Avg Alamar: 0.95
Knockdown %: failed
  PAK3
Link
PAK3
Link
 
Discovery» siRNA Focal Adhesion Phenotypes
Gene Description High-Res Montage
PAK3
Aliases: bPAK, MRX30, MRX47, OPHN3, hPAK3, CDKN1A, PAK3beta
Entrez Gene: 5063
siRNA catalog
p21 (CDKN1A)-activated kinase 3
mRNA: NM_002578
Library: Kinase
PAK3
Link
PAK3
Link