LIMK2 Orthologs
Aliases: LIM domain kinase 2, LIMK2
Pfam Domain Structure
From LIMK2 (human)
Members of the LIMK2 ortholog set
| Human | Mouse | Rat | Chicken | Fly | Worm | |
| CMKB | LIMK2 | Limk2 | Limk2 | LIMK2 | - | - |
| Entrez Gene | 3985 | 16886 | 29524 | 396010 | - | - |
| Uniprot | LIMK2_HUMAN | LIMK2_MOUSE | LIMK2_RAT | LIMK2_CHICK | - | - |
| OMIM | 601988 | - | - | - | - | - |
| Reagents | - | - | - | - | - | - |
| Results | 4 available | - | - | - | - | - |
References
- Bernard O. Lim kinases, regulators of actin dynamics. Int. J. Biochem. Cell Biol. 2007; 39:1071-6 (PubMed)
- Endo M, Ohashi K, Mizuno K. LIM kinase and slingshot are critical for neurite extension. J. Biol. Chem. 2007; 282:13692-702 (PubMed)
- Scott RW, Hooper S, Crighton D, Li A, König I, Munro J, Trivier E, Wickman G, Morin P, Croft DR, Dawson J, Machesky L, Anderson KI, Sahai EA, Olson MF. LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells. J. Cell Biol. 2010; 191:169-85 (PubMed)
- Scott RW, Olson MF. LIM kinases: function, regulation and association with human disease. J. Mol. Med. 2007; 85:555-68 (PubMed)
- Sumi T, Hashigasako A, Matsumoto K, Nakamura T. Different activity regulation and subcellular localization of LIMK1 and LIMK2 during cell cycle transition. Exp. Cell Res. 2006; 312:1021-30 (PubMed)
- Takahashi H, Funakoshi H, Nakamura T. LIM-kinase as a regulator of actin dynamics in spermatogenesis. Cytogenet. Genome Res. 2003; 103:290-8 (PubMed)
- Yang N, Higuchi O, Ohashi K, Nagata K, Wada A, Kangawa K, Nishida E, Mizuno K. Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization. Nature 1998; 393:809-12 (PubMed)
Consortium Results & Data
Discovery» siRNA migration screen using a wound healing approach
| Gene | Description | MCF-10A phenotype | Secondary screen | Wound Image | Morphology | Time-lapse |
|
LIMK2 Entrez Gene: 3985 siRNA catalog |
LIM domain kinase 2 mRNA: NM_005569 Library: Kinase Classification: Tyr Kinase |
Final bin: Discordant SMARTpool bin: Impaired Avg area: 2.38 Avg Alamar: 0.87 Knockdown %: 60-70 |
ERBB2: No Change |
Link |
Link |
Discovery» siRNA Focal Adhesion Phenotypes
| Gene | Description | High-Res | Montage |
|
LIMK2 Entrez Gene: 3985 siRNA catalog |
LIM domain kinase 2 mRNA: NM_005569 Library: Kinase |
Link |
Link |
Proteomics» Table 1. Identification and Quantitation of Proteins from Cell Body (CB) and Pseudopodium (PD) fractions
| IPI | Locus | Description | CB Spectra | CB peptide | PD Spectra | PD peptide | ratio |
| IPI00025698 | LIMK2 | LIMK2 PROTEIN. | 4 | 2 | 4 | 3 | 1.00 |
Proteomics» Table 2. Proteins in major organelles and subcellular compartments
| IPI | Locus | Description | CB Spectra | PD Spectra | ratio | Location |
| IPI00025698 | LIMK2 | LIMK2 PROTEIN. | 4 | 4 | 1 | Golgi |
| IPI00025698 | LIMK2 | LIMK2 PROTEIN. | 4 | 4 | 1 | nucleus |
