LIMK2 Orthologs

Aliases: LIM domain kinase 2, LIMK2

Pfam Domain Structure

From LIMK2 (human)

Members of the LIMK2 ortholog set
Human Mouse Rat Chicken Fly Worm
CMKB LIMK2 Limk2 Limk2 LIMK2 - -
Entrez Gene 3985 16886 29524 396010 - -
Uniprot LIMK2_HUMAN LIMK2_MOUSE LIMK2_RAT LIMK2_CHICK - -
OMIM 601988 - - - - -
Reagents - - - - - -
Results 4 available - - - - -
References
  1. Bernard O. Lim kinases, regulators of actin dynamics. Int. J. Biochem. Cell Biol. 2007; 39:1071-6 (PubMed)
  2. Endo M, Ohashi K, Mizuno K. LIM kinase and slingshot are critical for neurite extension. J. Biol. Chem. 2007; 282:13692-702 (PubMed)
  3. Scott RW, Hooper S, Crighton D, Li A, K├Ânig I, Munro J, Trivier E, Wickman G, Morin P, Croft DR, Dawson J, Machesky L, Anderson KI, Sahai EA, Olson MF. LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells. J. Cell Biol. 2010; 191:169-85 (Full Text)
  4. Scott RW, Olson MF. LIM kinases: function, regulation and association with human disease. J. Mol. Med. 2007; 85:555-68 (PubMed)
  5. Sumi T, Hashigasako A, Matsumoto K, Nakamura T. Different activity regulation and subcellular localization of LIMK1 and LIMK2 during cell cycle transition. Exp. Cell Res. 2006; 312:1021-30 (PubMed)
  6. Takahashi H, Funakoshi H, Nakamura T. LIM-kinase as a regulator of actin dynamics in spermatogenesis. Cytogenet. Genome Res. 2003; 103:290-8 (PubMed)
  7. Yang N, Higuchi O, Ohashi K, Nagata K, Wada A, Kangawa K, Nishida E, Mizuno K. Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization. Nature 1998; 393:809-12 (PubMed)
Consortium Results & Data
Discovery» siRNA migration screen using a wound healing approach
Gene Description     MCF-10A phenotype     Secondary screen Wound Image Morphology Time-lapse
LIMK2
Entrez Gene: 3985
siRNA catalog
LIM domain kinase 2
mRNA: NM_005569
Library: Kinase
Classification: Tyr Kinase
Final bin: Discordant
SMARTpool bin: Impaired
Avg area: 2.38
Avg Alamar: 0.87
Knockdown %: 60-70
ERBB2: No Change
LIMK2
Link
LIMK2
Link
 
Discovery» siRNA Focal Adhesion Phenotypes
Gene Description High-Res Montage
LIMK2
Entrez Gene: 3985
siRNA catalog
LIM domain kinase 2
mRNA: NM_005569
Library: Kinase
LIMK2
Link
LIMK2
Link
Proteomics» Table 1. Identification and Quantitation of Proteins from Cell Body (CB) and Pseudopodium (PD) fractions
IPI Locus Description CB Spectra CB peptide PD Spectra PD peptide ratio
IPI00025698 LIMK2 LIMK2 PROTEIN. 4 2 4 3 1.00
Proteomics» Table 2. Proteins in major organelles and subcellular compartments
IPI Locus Description CB Spectra PD Spectra ratio Location
IPI00025698 LIMK2 LIMK2 PROTEIN. 4 4 1 Golgi
IPI00025698 LIMK2 LIMK2 PROTEIN. 4 4 1 nucleus