LIMK1 Orthologs

Aliases: LIM motif-containing protein kinase, LIM domain kinase 1, LIMK, LIMK1

Pfam Domain Structure

From LIMK1 (human)

Members of the LIMK1 ortholog set
Human Mouse Rat Chicken Fly Worm
CMKB LIMK1 Limk1 Limk1 LIMK1 LIMK1 -
Entrez Gene 3984 16885 65172 373922 32207 -
Uniprot LIMK1_HUMAN LIMK1_MOUSE LIMK1_RAT LIMK1_CHICK LIMK1_DROME -
OMIM 601329 - - - - -
Reagents - - - - - -
Results 2 available - - - 1 available -
References
  1. Bernard O. Lim kinases, regulators of actin dynamics. Int. J. Biochem. Cell Biol. 2007; 39:1071-6 (PubMed)
  2. Endo M, Ohashi K, Mizuno K. LIM kinase and slingshot are critical for neurite extension. J. Biol. Chem. 2007; 282:13692-702 (PubMed)
  3. Scott RW, Hooper S, Crighton D, Li A, K├Ânig I, Munro J, Trivier E, Wickman G, Morin P, Croft DR, Dawson J, Machesky L, Anderson KI, Sahai EA, Olson MF. LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells. J. Cell Biol. 2010; 191:169-85 (Full Text)
  4. Scott RW, Olson MF. LIM kinases: function, regulation and association with human disease. J. Mol. Med. 2007; 85:555-68 (PubMed)
  5. Sumi T, Hashigasako A, Matsumoto K, Nakamura T. Different activity regulation and subcellular localization of LIMK1 and LIMK2 during cell cycle transition. Exp. Cell Res. 2006; 312:1021-30 (PubMed)
  6. Takahashi H, Funakoshi H, Nakamura T. LIM-kinase as a regulator of actin dynamics in spermatogenesis. Cytogenet. Genome Res. 2003; 103:290-8 (PubMed)
  7. Yang N, Higuchi O, Ohashi K, Nagata K, Wada A, Kangawa K, Nishida E, Mizuno K. Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization. Nature 1998; 393:809-12 (PubMed)
Consortium Results & Data
Discovery» Drosophila Morphology Genes
Gene Name Cell Count/
Normalization
Stellate11
NumCorners
Stellate22
Binsum6
Non-Spreading3
CG1848
Entrez Gene: 32207
LIM-kinase1
Aliases: LIM-kinase 1; LIM kinase; LIM-DOMAIN KINASE; LIM-kinase; Lim Kinase; Lim kinase; LIM Kinase1; LIM domain protein kinase; Lim-kinase
5.737
1.040
1.199 1.039 Actin: 1.003
Area: 1.023
Ratio: 0.980
Discovery» siRNA migration screen using a wound healing approach
Gene Description     MCF-10A phenotype     Secondary screen Wound Image Morphology Time-lapse
LIMK1
Aliases: LIMK
Entrez Gene: 3984
siRNA catalog
LIM domain kinase 1
mRNA: NM_002314
Library: Kinase
Classification: Tyr Kinase
Focal Adhesion Related: Yes
Final bin: Discordant
SMARTpool bin: No change
Avg area: 1.62
Avg Alamar: 1.02
Knockdown %: 90-100
  LIMK1
Link
LIMK1
Link
 
Discovery» siRNA Focal Adhesion Phenotypes
Gene Description High-Res Montage
LIMK1
Aliases: LIMK
Entrez Gene: 3984
siRNA catalog
LIM domain kinase 1
mRNA: NM_002314
Library: Kinase
LIMK1
Link
LIMK1
Link
Pathways

How many degrees of interaction?

Update
Legend: Legend for CMKB pathways