BCAR1 Orthologs

Aliases: breast cancer anti-estrogen resistance 1, Cas scaffolding protein family member 1, Crk-associated substrate p130Cas, CAS, BCAR1, CAS1, CASS1, CRKAS, P130Cas

Processes & Diseases

Processes involved: adhesion

Pfam Domain Structure

From Bcar1 (rat)

Members of the BCAR1 ortholog set
Human Mouse Rat Chicken Fly Worm
CMKB BCAR1 Bcar1 Bcar1 BCAR1 p130CAS -
Entrez Gene 9564 12927 25414 415691 38021 -
Uniprot BCAR1_HUMAN BCAR1_MOUSE BCAR1_RAT - - -
OMIM 602941 - - - - -
Reagents - 3 available - - - -
Results 3 available - - - 2 available -
References
  1. Cox BD, Natarajan M, Stettner MR, Gladson CL. New concepts regarding focal adhesion kinase promotion of cell migration and proliferation. J. Cell. Biochem. 2006; 99:35-52 (PubMed)
  2. Defilippi P, Di Stefano P, Cabodi S. p130Cas: a versatile scaffold in signaling networks. Trends Cell Biol. 2006; 16:257-63 (PubMed)
  3. Panetti TS. Tyrosine phosphorylation of paxillin, FAK, and p130CAS: effects on cell spreading and migration. Front. Biosci. 2002; 7:d143-50 (PubMed)
  4. Sanders MA, Basson MD. Collagen IV regulates Caco-2 cell spreading and p130Cas phosphorylation by FAK-dependent and FAK-independent pathways. Biol. Chem. 2008; 389:47-55 (Full Text)
  5. Sawada Y, Tamada M, Dubin-Thaler BJ, Cherniavskaya O, Sakai R, Tanaka S, Sheetz MP. Force sensing by mechanical extension of the Src family kinase substrate p130Cas. Cell 2006; 127:1015-26 (Full Text)
  6. Seo S, Ichikawa M, Kurokawa M. Structure and function of cas-L and integrin-mediated signaling. Crit. Rev. Immunol. 2006; 26:391-406 (PubMed)
  7. Webb DJ, Donais K, Whitmore LA, Thomas SM, Turner CE, Parsons JT, Horwitz AF. FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly. Nat. Cell Biol. 2004; 6:154-61 (PubMed)
Consortium Results & Data
Results & Data
Ortholog Species Type Description Method Status Source Publications
BCAR1 none phosphorylation site p130Cas Myc-tagged and expressed in HEK cells 9 phospho-sites in 87.0% coverage of 977 aa Parsons
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Discovery» Drosophila Morphology Genes
Gene Name Cell Count/
Normalization
Stellate11
NumCorners
Stellate22
Binsum6
Non-Spreading3
CG1212
Entrez Gene: 38021
p130CAS 4.647
0.844
0.834 0.919 Actin: 0.929
Area: 0.994
Ratio: 0.935

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Consortium Related Products*
Mice » activity page
Ortholog Species Name Method Phenotype Status Jax Availability Source Publications
BCAR1 mouse FAK / Cas - double knockout in embryonic fibroblasts
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Defects in ephrinA1-induced cell spreading. completed
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Carter et al.
BCAR1 mouse CAS (p130)
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Embryonic lethality showing systemic congestion and growth retardation. completed
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-
Honda et al.
BCAR1 mouse CAS (p130) - embryonic fibroblasts
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Impaired formation of actin stress fibers, reduced cell spreading, cell migration, and transformation by activated Src. completed
-
-
Honda et al.

* The resources presented here are largely those generated by the Consortium. The sidebar provides public databases that complement Consortium activities. For mice and biosensors, a public database is not available and therefore we have attempted to generate a migration related list for your convenience.

Pathways

How many degrees of interaction?

Update
Legend: Legend for CMKB pathways