BCAR1 Orthologs

Aliases: breast cancer anti-estrogen resistance 1, Cas scaffolding protein family member 1, Crk-associated substrate p130Cas, CAS, BCAR1, CAS1, CASS1, CRKAS, P130Cas

Processes & Diseases

Processes involved: adhesion

Pfam Domain Structure

From Bcar1 (rat)

Members of the BCAR1 ortholog set
Human Mouse Rat Chicken Fly Worm
CMKB BCAR1 Bcar1 Bcar1 BCAR1 p130CAS -
Entrez Gene 9564 12927 25414 415691 38021 -
Uniprot BCAR1_HUMAN BCAR1_MOUSE BCAR1_RAT - - -
OMIM 602941 - - - - -
Reagents - 3 available - - - -
Results 3 available - - - 2 available -
References
  1. Cox BD, Natarajan M, Stettner MR, Gladson CL. New concepts regarding focal adhesion kinase promotion of cell migration and proliferation. J. Cell. Biochem. 2006; 99:35-52 (PubMed)
  2. Defilippi P, Di Stefano P, Cabodi S. p130Cas: a versatile scaffold in signaling networks. Trends Cell Biol. 2006; 16:257-63 (PubMed)
  3. Panetti TS. Tyrosine phosphorylation of paxillin, FAK, and p130CAS: effects on cell spreading and migration. Front. Biosci. 2002; 7:d143-50 (PubMed)
  4. Sanders MA, Basson MD. Collagen IV regulates Caco-2 cell spreading and p130Cas phosphorylation by FAK-dependent and FAK-independent pathways. Biol. Chem. 2008; 389:47-55 (Full Text)
  5. Sawada Y, Tamada M, Dubin-Thaler BJ, Cherniavskaya O, Sakai R, Tanaka S, Sheetz MP. Force sensing by mechanical extension of the Src family kinase substrate p130Cas. Cell 2006; 127:1015-26 (Full Text)
  6. Seo S, Ichikawa M, Kurokawa M. Structure and function of cas-L and integrin-mediated signaling. Crit. Rev. Immunol. 2006; 26:391-406 (PubMed)
  7. Webb DJ, Donais K, Whitmore LA, Thomas SM, Turner CE, Parsons JT, Horwitz AF. FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly. Nat. Cell Biol. 2004; 6:154-61 (PubMed)
Consortium Results & Data
Results & Data
Ortholog Species Type Description Method Status Source Publications
BCAR1 none phosphorylation site p130Cas Myc-tagged and expressed in HEK cells 9 phospho-sites in 87.0% coverage of 977 aa Parsons
-
Discovery» siRNA migration screen using a wound healing approach
Gene Description     MCF-10A phenotype     Secondary screen Wound Image Morphology Time-lapse
BCAR1
Aliases: CAS, CRKAS, P130Cas
Entrez Gene: 9564
siRNA catalog
breast cancer anti-estrogen resistance 1
mRNA: NM_014567
Library: MAR
Classification: cytoskeletal
Focal Adhesion Related: Yes
Final bin: Discordant
SMARTpool bin: Low Alamar
Avg area: 3.89
Avg Alamar: 0.68
Knockdown %: not done
ERBB2: Impaired
BCL2: Low Alamar
BCAR1
Link
BCAR1
Link
 
Discovery» siRNA Focal Adhesion Phenotypes
Gene Description High-Res Montage
BCAR1
Aliases: CAS, CRKAS, P130Cas
Entrez Gene: 9564
siRNA catalog
breast cancer anti-estrogen resistance 1
mRNA: NM_014567
Library: MAR
BCAR1
Link
BCAR1
Link
Proteomics» Table 1. Identification and Quantitation of Proteins from Cell Body (CB) and Pseudopodium (PD) fractions
IPI Locus Description CB Spectra CB peptide PD Spectra PD peptide ratio
IPI00011998 BCAR1 CRK-ASSOCIATED SUBSTRATE. 5 3 3 2 0.60
Discovery» wt-migratory_cells vs wt-non-migratory_cells
Symbol Description Median Values Fold Change Probe ID
CG1212
Flybase
Entrez
CMCKB
CG1212 gene product from transcript CG1212-RA Mig: 131.0
Non-Mig: 124.4
1.05310 151870_at
Discovery» Drosophila Morphology Genes
Gene Name Cell Count/
Normalization
Stellate11
NumCorners
Stellate22
Binsum6
Non-Spreading3
CG1212
Entrez Gene: 38021
p130CAS 4.647
0.844
0.834 0.919 Actin: 0.929
Area: 0.994
Ratio: 0.935
Consortium Related Products*
Mice » activity page
Ortholog Species Name Method Phenotype Status Jax Availability Source Publications
BCAR1 mouse FAK / Cas - double knockout in embryonic fibroblasts
-
Defects in ephrinA1-induced cell spreading. completed
-
-
Carter et al.
BCAR1 mouse CAS (p130)
-
Embryonic lethality showing systemic congestion and growth retardation. completed
-
-
Honda et al.
BCAR1 mouse CAS (p130) - embryonic fibroblasts
-
Impaired formation of actin stress fibers, reduced cell spreading, cell migration, and transformation by activated Src. completed
-
-
Honda et al.

* The resources presented here are largely those generated by the Consortium. The sidebar provides public databases that complement Consortium activities. For mice and biosensors, a public database is not available and therefore we have attempted to generate a migration related list for your convenience.

Pathways

How many degrees of interaction?

Update
Legend: Legend for CMKB pathways