GRLF1 Orthologs

Aliases: glucocorticoid receptor DNA binding factor 1, GRLF1, GRF-1, P190A, P190-A, KIAA1722, MGC10745, p190RhoGAP

Processes & Diseases

Processes involved: adhesion

Pfam Domain Structure

From GRLF1 (human)

Members of the GRLF1 ortholog set
Human Mouse Rat Chicken Fly Worm
CMKB GRLF1 Grlf1 Grlf1 GRLF1 RhoGAPp190 -
Entrez Gene 2909 232906 306400 425730 32743 -
Uniprot GRLF1_HUMAN GRLF1_MOUSE GRLF1_RAT - - -
OMIM 605277 - - - - -
Reagents - - - - - -
Results 5 available - - - 1 available -
References
  1. Gen Y, Yasui K, Zen K, Nakajima T, Tsuji K, Endo M, Mitsuyoshi H, Minami M, Itoh Y, Tanaka S, Taniwaki M, Arii S, Okanoue T, Yoshikawa T. A novel amplification target, ARHGAP5, promotes cell spreading and migration by negatively regulating RhoA in Huh-7 hepatocellular carcinoma cells. Cancer Lett. 2009; 275:27-34 (PubMed)
  2. Hakoshima T, Shimizu T, Maesaki R. Structural basis of the Rho GTPase signaling. J. Biochem. 2003; 134:327-31 (PubMed)
  3. Heckman BM, Chakravarty G, Vargo-Gogola T, Gonzales-Rimbau M, Hadsell DL, Lee AV, Settleman J, Rosen JM. Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development. Dev. Biol. 2007; 309:137-49 (PubMed)
  4. Holinstat M, Knezevic N, Broman M, Samarel AM, Malik AB, Mehta D. Suppression of RhoA activity by focal adhesion kinase-induced activation of p190RhoGAP: role in regulation of endothelial permeability. J. Biol. Chem. 2006; 281:2296-305 (PubMed)
  5. Lener T, Burgstaller G, Crimaldi L, Lach S, Gimona M. Matrix-degrading podosomes in smooth muscle cells. Eur. J. Cell Biol. 2006; 85:183-9 (PubMed)
  6. Matheson SF, Hu KQ, Brouns MR, Sordella R, VanderHeide JD, Settleman J. Distinct but overlapping functions for the closely related p190 RhoGAPs in neural development. Dev. Neurosci. 2006; 28:538-50 (PubMed)
Consortium Results & Data
Discovery» Drosophila Morphology Genes
Gene Name Cell Count/
Normalization
Stellate11
NumCorners
Stellate22
Binsum6
Non-Spreading3
CG32555
Entrez Gene: 32743
RhoGAPp190
Aliases: Rp190RhoGAP
5.222
0.887
0.882 0.965 Actin: 1.102
Area: 1.019
Ratio: 1.081

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