ITGA7 Orthologs

Aliases: integrin alpha 7, integrin alpha 7 chain, Integrin alpha-7 heavy chain, Integrin alpha-7 light chain, ITGA7, FLJ25220

Pfam Domain Structure

From ITGA7 (human)

Members of the ITGA7 ortholog set
Human Mouse Rat Chicken Fly Worm
CMKB ITGA7 Itga7 Itga7 - mew ina-1
Entrez Gene 3679 16404 81008 - 32275 176296
Uniprot ITA7_HUMAN ITA7_MOUSE ITA7_RAT - ITA1_DROME INA1_CAEEL
OMIM 600536 - - - - -
Reagents - - - - - -
Results - - - - 3 available 1 available
References
  1. Caswell PT, Vadrevu S, Norman JC. Integrins: masters and slaves of endocytic transport. Nat. Rev. Mol. Cell Biol. 2009; 10:843-53 (PubMed)
  2. Delon I, Brown NH. Integrins and the actin cytoskeleton. Curr. Opin. Cell Biol. 2007; 19:43-50 (PubMed)
  3. Eckes B, Zweers MC, Zhang ZG, Hallinger R, Mauch C, Aumailley M, Krieg T. Mechanical tension and integrin alpha 2 beta 1 regulate fibroblast functions. J. Investig. Dermatol. Symp. Proc. 2006; 11:66-72 (PubMed)
  4. Humphries JD, Byron A, Humphries MJ. Integrin ligands at a glance. J. Cell. Sci. 2006; 119:3901-3 (PubMed)
  5. Hynes RO. Integrins: bidirectional, allosteric signaling machines. Cell 2002; 110:673-87 (PubMed)
  6. Kim M, Carman CV, Springer TA. Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins. Science 2003; 301:1720-5 (PubMed)
  7. Luo BH, Carman CV, Springer TA. Structural basis of integrin regulation and signaling. Annu. Rev. Immunol. 2007; 25:619-47 (Full Text)
  8. Luo BH, Springer TA. Integrin structures and conformational signaling. Curr. Opin. Cell Biol. 2006; 18:579-86 (Full Text)
  9. Vicente-Manzanares M, Choi CK, Horwitz AR. Integrins in cell migration--the actin connection. J. Cell. Sci. 2009; 122:199-206 (Full Text)
  10. Wiesner S, Legate KR, Fässler R. Integrin-actin interactions. Cell. Mol. Life Sci. 2005; 62:1081-99 (PubMed)
  11. Zaidel-Bar R, Geiger B. The switchable integrin adhesome. J. Cell. Sci. 2010; 123:1385-8 (Full Text)
  12. Zaidel-Bar R, Itzkovitz S, Ma'ayan A, Iyengar R, Geiger B. Functional atlas of the integrin adhesome. Nat. Cell Biol. 2007; 9:858-67 (Full Text)
  13. Zargham R. Tensegrin in context: Dual role of alpha8 integrin in the migration of different cell types. Cell Adh Migr 2010; 4: (Full Text)
  14. Zhu CQ, Popova SN, Brown ER, Barsyte-Lovejoy D, Navab R, Shih W, Li M, Lu M, Jurisica I, Penn LZ, Gullberg D, Tsao MS. Integrin alpha 11 regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell lung cancer cells. Proc. Natl. Acad. Sci. U.S.A. 2007; 104:11754-9 (Full Text)
  15. Zutter MM, Edelson BT. The alpha2beta1 integrin: a novel collectin/C1q receptor. Immunobiology 2007; 212:343-53 (PubMed)
Consortium Results & Data
Discovery» C. elegans genes affecting migration
Gene Description/Function Parental P0 defect Distribution1
(percent)
Progeny F1 defect Distribution2
(percent)
Express DTC Express BWM
Gene: ina‑1 (F54G8.3)
Gene Pair ID
CMKB
Entrez Gene
INtegrin Alpha
AhringerAutoClass: Cell Architecture
Function: Cell Architecture
0.33 (N=84)
0.23 – 0.44
Type 1: 43
Type 2: 0
Type 3: 57
0.26 (N=78)
0.16 – 0.37
Type 1: 10
Type 2: 0
Type 3: 90
Yes
 
Discovery» Drosophila Migration Genes
Gene Name Function Cell
Type
Phenotypes Reagents/
Alleles
Reference
mew
Entrez: CG1771
Flybase: FBgn0004456
multiple edematous wings alphaPS1 integrin subunit embryonic endoderm Loss of function: Modest Migration delay, act redundantly with aplhaPS3, Severe migration delay when both alpha subunits mutated
Autonomous: autonomous
mewM6 Martin-Bermudo et al., 1999; Stark et al., 1997
Discovery» wt-migratory_cells vs wt-non-migratory_cells
Symbol Description Median Values Fold Change Probe ID
mew
Flybase
Entrez
CMCKB
multiple edematous wings Mig: 237.2
Non-Mig: 308.7
0.76840 152588_at
Discovery» Drosophila Morphology Genes
Gene Name Cell Count/
Normalization
Stellate11
NumCorners
Stellate22
Binsum6
Non-Spreading3
CG1771
Entrez Gene: 32275
multiple edematous wings
Aliases: PS1 integrin; alphaPS1 integrin; alpha integrin; alpha-PS1-integrin; Position-specific-1 antigen; Position-specific-antigen-1alpha; multiple edematous wing; alpha1 integrin; alphaPS integrin; alpha[[PS1]] subunit of integrin; integrin alphaPS1
14.364
2.109
1.092 1.043 Actin: 0.931
Area: 0.866
Ratio: 1.075