ITGA3 Orthologs

Aliases: antigen identified by monoclonal antibody J143, Galactoprotein B3, VLA-3 alpha chain, integrin alpha 3, very late activation protein 3 receptor, alpha-3 subunit, CD49 antigen-like family member C, Integrin alpha-3 heavy chain, Integrin alpha-3 light chain, VL3A, FRP-2, ITGA3, FLJ34631, FLJ34704, CD49C, GAPB3, MSK18, VCA-2, VLA3a, GAP-B3

Pfam Domain Structure

From ITGA3 (human)

Members of the ITGA3 ortholog set
Human Mouse Rat Chicken Fly Worm
CMKB ITGA3 Itga3 Itga3 - - -
Entrez Gene 3675 16400 360606 - - -
Uniprot ITA3_HUMAN ITA3_MOUSE - - - -
OMIM 605025 - - - - -
Reagents - - - - - -
Results 3 available - - - - -
References
  1. Caswell PT, Vadrevu S, Norman JC. Integrins: masters and slaves of endocytic transport. Nat. Rev. Mol. Cell Biol. 2009; 10:843-53 (PubMed)
  2. Delon I, Brown NH. Integrins and the actin cytoskeleton. Curr. Opin. Cell Biol. 2007; 19:43-50 (PubMed)
  3. Eckes B, Zweers MC, Zhang ZG, Hallinger R, Mauch C, Aumailley M, Krieg T. Mechanical tension and integrin alpha 2 beta 1 regulate fibroblast functions. J. Investig. Dermatol. Symp. Proc. 2006; 11:66-72 (PubMed)
  4. Humphries JD, Byron A, Humphries MJ. Integrin ligands at a glance. J. Cell. Sci. 2006; 119:3901-3 (PubMed)
  5. Hynes RO. Integrins: bidirectional, allosteric signaling machines. Cell 2002; 110:673-87 (PubMed)
  6. Kim M, Carman CV, Springer TA. Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins. Science 2003; 301:1720-5 (PubMed)
  7. Luo BH, Carman CV, Springer TA. Structural basis of integrin regulation and signaling. Annu. Rev. Immunol. 2007; 25:619-47 (Full Text)
  8. Luo BH, Springer TA. Integrin structures and conformational signaling. Curr. Opin. Cell Biol. 2006; 18:579-86 (Full Text)
  9. Vicente-Manzanares M, Choi CK, Horwitz AR. Integrins in cell migration--the actin connection. J. Cell. Sci. 2009; 122:199-206 (Full Text)
  10. Wiesner S, Legate KR, Fässler R. Integrin-actin interactions. Cell. Mol. Life Sci. 2005; 62:1081-99 (PubMed)
  11. Zaidel-Bar R, Geiger B. The switchable integrin adhesome. J. Cell. Sci. 2010; 123:1385-8 (Full Text)
  12. Zaidel-Bar R, Itzkovitz S, Ma'ayan A, Iyengar R, Geiger B. Functional atlas of the integrin adhesome. Nat. Cell Biol. 2007; 9:858-67 (Full Text)
  13. Zargham R. Tensegrin in context: Dual role of alpha8 integrin in the migration of different cell types. Cell Adh Migr 2010; 4: (Full Text)
  14. Zhu CQ, Popova SN, Brown ER, Barsyte-Lovejoy D, Navab R, Shih W, Li M, Lu M, Jurisica I, Penn LZ, Gullberg D, Tsao MS. Integrin alpha 11 regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell lung cancer cells. Proc. Natl. Acad. Sci. U.S.A. 2007; 104:11754-9 (Full Text)
  15. Zutter MM, Edelson BT. The alpha2beta1 integrin: a novel collectin/C1q receptor. Immunobiology 2007; 212:343-53 (PubMed)
Consortium Results & Data
Discovery» siRNA migration screen using a wound healing approach
Gene Description     MCF-10A phenotype     Secondary screen Wound Image Morphology Time-lapse
ITGA3
Aliases: VL3A, CD49C, GAPB3, MSK18, VCA-2, VLA3a, GAP-B3
Entrez Gene: 3675
siRNA catalog
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
mRNA: NM_002204
Library: MAR
Classification: integrin
Focal Adhesion Related: Yes
Final bin: Discordant
SMARTpool bin: Impaired *
Avg area: 1.85
Avg Alamar: 0.83
Knockdown %: not done
ERBB2: No Change
ITGA3
Link
ITGA3
Link
 
Discovery» siRNA Focal Adhesion Phenotypes
Gene Description High-Res Montage
ITGA3
Aliases: VL3A, CD49C, GAPB3, MSK18, VCA-2, VLA3a, GAP-B3
Entrez Gene: 3675
siRNA catalog
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
mRNA: NM_002204
Library: MAR
ITGA3
Link
ITGA3
Link
Proteomics» Table 1. Identification and Quantitation of Proteins from Cell Body (CB) and Pseudopodium (PD) fractions
IPI Locus Description CB Spectra CB peptide PD Spectra PD peptide ratio
IPI00215995 ITGA3 SPLICE ISOFORM ALPHA-3A OF INTEGRIN ALPHA-3 PRECURSOR. 20 9 49 14 2.45