MAPK1 Orthologs

Aliases: protein tyrosine kinase ERK2, mitogen-activated protein kinase 1, mitogen-activated protein kinase 2, extracellular signal-regulated kinase 2, ERK, MAPK1, p38, p40, p41, ERK2, ERT1, MAPK2, PRKM1, PRKM2, P42MAPK, p41mapk

Pfam Domain Structure

From MAPK1 (human)

Members of the MAPK1 ortholog set
Human Mouse Rat Chicken Fly Worm
CMKB MAPK1 Mapk1 Mapk1 MAPK1 rl mpk-1
Entrez Gene 5594 26413 116590 373953 3354888 175545
Uniprot MK01_HUMAN MK01_MOUSE MK01_RAT - ERKA_DROME SUR1_CAEEL
OMIM 176948 - - - - -
Reagents - - - - - -
Results 5 available - - - 1 available -
References
  1. Bode AM, Dong Z. The functional contrariety of JNK. Mol. Carcinog. 2007; 46:591-8 (Full Text)
  2. Borsello T, Forloni G. JNK signalling: a possible target to prevent neurodegeneration. Curr. Pharm. Des. 2007; 13:1875-86 (PubMed)
  3. Cook R, Wu CC, Kang YJ, Han J. The role of the p38 pathway in adaptive immunity. Cell. Mol. Immunol. 2007; 4:253-9 (PubMed)
  4. Dominguez C, Powers DA, Tamayo N. p38 MAP kinase inhibitors: many are made, but few are chosen. Curr Opin Drug Discov Devel 2005; 8:421-30 (PubMed)
  5. Meloche S, Pouysségur J. The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition. Oncogene 2007; 26:3227-39 (PubMed)
  6. Raman M, Chen W, Cobb MH. Differential regulation and properties of MAPKs. Oncogene 2007; 26:3100-12 (PubMed)
  7. Roberts OL, Holmes K, Müller J, Cross DA, Cross MJ. ERK5 and the regulation of endothelial cell function. Biochem. Soc. Trans. 2009; 37:1254-9 (PubMed)
  8. Roberts PJ, Der CJ. Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene 2007; 26:3291-310 (PubMed)
  9. Shaul YD, Seger R. The MEK/ERK cascade: from signaling specificity to diverse functions. Biochim. Biophys. Acta 2007; 1773:1213-26 (PubMed)
  10. Stains CI, Luković E, Imperiali B. A p38α-selective chemosensor for use in unfractionated cell lysates. ACS Chem. Biol. 2011; 6:101-5 (Full Text)
  11. Turjanski AG, Vaqué JP, Gutkind JS. MAP kinases and the control of nuclear events. Oncogene 2007; 26:3240-53 (PubMed)
  12. Wang Y. Mitogen-activated protein kinases in heart development and diseases. Circulation 2007; 116:1413-23 (PubMed)
Consortium Results & Data
Discovery» Drosophila Migration Genes
Gene Name Function Cell
Type
Phenotypes Reagents/
Alleles
Reference
rl
Entrez: CG12559
Flybase: FBgn0003256
rolled serine/threonine kinase, ERK, MAP kinase embryonic trachea Loss of function: defects in branch continuity
Autonomous: autonomous

Comments: MAP kinase pathway
Carolina Cela,2006
Discovery» siRNA migration screen using a wound healing approach
Gene Description     MCF-10A phenotype     Secondary screen Wound Image Morphology Time-lapse
MAPK1
Aliases: ERK, p38, p40, p41, ERK2, ERT1, MAPK2, PRKM1, PRKM2, P42MAPK, p41mapk
Entrez Gene: 5594
siRNA catalog
mitogen-activated protein kinase 1
mRNA: NM_002745
Library: Kinase
Classification: Ser/Thr Kinase
Focal Adhesion Related: Yes
Final bin: Low Alamar - MC
SMARTpool bin: Low Alamar
Avg area: 3.27
Avg Alamar: 0.67
Knockdown %: 90-100
ERBB2: Impaired
BCL2: Low Alamar
MAPK1
Link
MAPK1
Link
 
Discovery» siRNA Focal Adhesion Phenotypes
Gene Description High-Res Montage
MAPK1
Aliases: ERK, p38, p40, p41, ERK2, ERT1, MAPK2, PRKM1, PRKM2, P42MAPK, p41mapk
Entrez Gene: 5594
siRNA catalog
mitogen-activated protein kinase 1
mRNA: NM_002745
Library: Kinase
MAPK1
Link
MAPK1
Link
Proteomics» Table 1. Identification and Quantitation of Proteins from Cell Body (CB) and Pseudopodium (PD) fractions
IPI Locus Description CB Spectra CB peptide PD Spectra PD peptide ratio
IPI00003479 MAPK1 MITOGEN-ACTIVATED PROTEIN KINASE 1. 33 12 37 12 1.12
Proteomics» Table 2. Proteins in major organelles and subcellular compartments
IPI Locus Description CB Spectra PD Spectra ratio Location
IPI00003479 MAPK1 MITOGEN-ACTIVATED PROTEIN KINASE 1. 33 37 1.12 nucleus
Proteomics» Table 3. Quantitation of phosphopeptides identified in Pseudopodium (PD) and Cell Body (CB) fractions
IPI Locus Description peptide pdcb_p pdcb_t ratio Mouse homology Rat homology Zebrafish homology sd Variable sites
IPI00003479 MAPK1 MITOGEN-ACTIVATED PROTEIN KINASE 1 . VADPDHDHTGFLT*EY*VATR 34.1 1.12 30.45 +++ +++ +++ 4.68  
Consortium Related Products*
Biosensors » activity page
Ortholog Species Name Type Source Publications
MAPK1 none Erk Intramolecular FRET between FPs - CFP-Erk-YFP
-
Sato et al.

* The resources presented here are largely those generated by the Consortium. The sidebar provides public databases that complement Consortium activities. For mice and biosensors, a public database is not available and therefore we have attempted to generate a migration related list for your convenience.

Pathways

How many degrees of interaction?

Update
Legend: Legend for CMKB pathways