RAC2 Orthologs

Aliases: small G protein, Ras-related C3 botulinum toxin substrate 2, rho family, small GTP binding protein Rac2, Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP-binding protein Rac2), Gx, RAC2, EN-7, HSPC022

Pfam Domain Structure

From RAC2 (human)

Members of the RAC2 ortholog set
Human Mouse Rat Chicken Fly Worm
CMKB RAC2 Rac2 Rac2 RAC2 - -
Entrez Gene 5880 19354 366957 418044 - -
Uniprot RAC2_HUMAN RAC2_MOUSE RAC2_MOUSE - - -
OMIM 602049 - - - - -
Reagents - 3 available - - - -
Results 2 available - - - - -
References
  1. Chan JR. Myelination: all about Rac 'n' roll. J. Cell Biol. 2007; 177:953-5 (Full Text)
  2. Heasman SJ, Ridley AJ. Mammalian Rho GTPases: new insights into their functions from in vivo studies. Nat. Rev. Mol. Cell Biol. 2008; 9:690-701 (PubMed)
  3. Nikolova E, Mitev V, Zhelev N, Deroanne CF, Poumay Y. The small Rho GTPase Rac1 controls normal human dermal fibroblasts proliferation with phosphorylation of the oncoprotein c-myc. Biochem. Biophys. Res. Commun. 2007; 359:834-9 (PubMed)
  4. Palamidessi A, Frittoli E, Garré M, Faretta M, Mione M, Testa I, Diaspro A, Lanzetti L, Scita G, Di Fiore PP. Endocytic trafficking of Rac is required for the spatial restriction of signaling in cell migration. Cell 2008; 134:135-47 (PubMed)
  5. Ridley AJ. Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking. Trends Cell Biol. 2006; 16:522-9 (PubMed)
  6. Ridley AJ, Paterson HF, Johnston CL, Diekmann D, Hall A. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 1992; 70:401-10 (PubMed)
  7. Rose DM, Alon R, Ginsberg MH. Integrin modulation and signaling in leukocyte adhesion and migration. Immunol. Rev. 2007; 218:126-34 (PubMed)
  8. Rottner K, Hall A, Small JV. Interplay between Rac and Rho in the control of substrate contact dynamics. Curr. Biol. 1999; 9:640-8 (PubMed)
  9. Sander EE, ten Klooster JP, van Delft S, van der Kammen RA, Collard JG. Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behavior. J. Cell Biol. 1999; 147:1009-22 (Full Text)
  10. Watabe-Uchida M, Govek EE, Van Aelst L. Regulators of Rho GTPases in neuronal development. J. Neurosci. 2006; 26:10633-5 (PubMed)
  11. Wittmann T, Bokoch GM, Waterman-Storer CM. Regulation of microtubule destabilizing activity of Op18/stathmin downstream of Rac1. J. Biol. Chem. 2004; 279:6196-203 (PubMed)
  12. Yang N, Higuchi O, Ohashi K, Nagata K, Wada A, Kangawa K, Nishida E, Mizuno K. Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization. Nature 1998; 393:809-12 (PubMed)
Consortium Results & Data
Discovery» siRNA migration screen using a wound healing approach
Gene Description     MCF-10A phenotype     Secondary screen Wound Image Morphology Time-lapse
RAC2
Aliases: Gx, EN-7, HSPC022
Entrez Gene: 5880
siRNA catalog
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
mRNA: NM_002872
Library: MAR
Classification: GTPase
Final bin: Discordant
SMARTpool bin: No change
Avg area: 1.63
Avg Alamar: 0.97
Knockdown %: not done
  RAC2
Link
RAC2
Link
 
Discovery» siRNA Focal Adhesion Phenotypes
Gene Description High-Res Montage
RAC2
Aliases: Gx, EN-7, HSPC022
Entrez Gene: 5880
siRNA catalog
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
mRNA: NM_002872
Library: MAR
RAC2
Link
RAC2
Link
Consortium Related Products*
Mice » activity page
Ortholog Species Name Method Phenotype Status Jax Availability Source Publications
RAC2 mouse Rac2 - neutrophils
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Neutrophils display significant defects in chemotaxis, in shear-dependent L-selectin-mediated capture on the endothelial substrate Glycam-1 and in both F-actin generation and p38 and unexpected p42/p44 MAP kinase activation induced by chemoattractants. Superoxide production by bone marrow neutrophils was also significantly reduced. completed
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Roberts et al.
RAC2 mouse Rac2 - T cells
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Proliferation was reduced in Rac2(-/-) T cells upon stimulation with either plate-bound anti-CD3 or T cell receptor-specific antigen and was accompanied by decreased activation of mitogen activated protein kinase extracellular signal-regulated kinase (ERK) 1/2 and p38 as well as reduced Ca (2)+ mobilization. TCR stimulation-induced actin polymerization was reduced and there were significant phenotypic similarities with Vav (-/-) cells implication Rac2 as a downstream mediator of Vav signaling. completed
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Yu et al.
RAC2 mouse Rac2 - null
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Mice show baseline neutrophilia, reduced inflammatory peritoneal exudate formation and increased mortality when challenged with Aspergillus fumigatus. completed
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Roberts et al.

* The resources presented here are largely those generated by the Consortium. The sidebar provides public databases that complement Consortium activities. For mice and biosensors, a public database is not available and therefore we have attempted to generate a migration related list for your convenience.