ITGAV Orthologs

Aliases: antigen identified by monoclonal antibody L230, integrin alpha-V, Integrin, alpha-V (vitronectin receptor, alpha polypeptide), CD51, ITGAV, DKFZp686A08142, MSK8, VNRA

Pfam Domain Structure

From ITGAV (human)

Members of the ITGAV ortholog set
Human Mouse Rat Chicken Fly Worm
CMKB ITGAV Itgav Itgav ITGAV if -
Entrez Gene 3685 16410 296456 396420 32661 -
Uniprot ITAV_HUMAN ITAV_MOUSE - ITAV_CHICK ITA2_DROME -
OMIM 193210 - - - - -
Reagents - - - - - -
Results 3 available - - - 2 available -
References
  1. Caswell PT, Vadrevu S, Norman JC. Integrins: masters and slaves of endocytic transport. Nat. Rev. Mol. Cell Biol. 2009; 10:843-53 (PubMed)
  2. Delon I, Brown NH. Integrins and the actin cytoskeleton. Curr. Opin. Cell Biol. 2007; 19:43-50 (PubMed)
  3. Eckes B, Zweers MC, Zhang ZG, Hallinger R, Mauch C, Aumailley M, Krieg T. Mechanical tension and integrin alpha 2 beta 1 regulate fibroblast functions. J. Investig. Dermatol. Symp. Proc. 2006; 11:66-72 (PubMed)
  4. Humphries JD, Byron A, Humphries MJ. Integrin ligands at a glance. J. Cell. Sci. 2006; 119:3901-3 (PubMed)
  5. Hynes RO. Integrins: bidirectional, allosteric signaling machines. Cell 2002; 110:673-87 (PubMed)
  6. Kim M, Carman CV, Springer TA. Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins. Science 2003; 301:1720-5 (PubMed)
  7. Luo BH, Carman CV, Springer TA. Structural basis of integrin regulation and signaling. Annu. Rev. Immunol. 2007; 25:619-47 (Full Text)
  8. Luo BH, Springer TA. Integrin structures and conformational signaling. Curr. Opin. Cell Biol. 2006; 18:579-86 (Full Text)
  9. Vicente-Manzanares M, Choi CK, Horwitz AR. Integrins in cell migration--the actin connection. J. Cell. Sci. 2009; 122:199-206 (Full Text)
  10. Wiesner S, Legate KR, Fässler R. Integrin-actin interactions. Cell. Mol. Life Sci. 2005; 62:1081-99 (PubMed)
  11. Zaidel-Bar R, Geiger B. The switchable integrin adhesome. J. Cell. Sci. 2010; 123:1385-8 (Full Text)
  12. Zaidel-Bar R, Itzkovitz S, Ma'ayan A, Iyengar R, Geiger B. Functional atlas of the integrin adhesome. Nat. Cell Biol. 2007; 9:858-67 (Full Text)
  13. Zargham R. Tensegrin in context: Dual role of alpha8 integrin in the migration of different cell types. Cell Adh Migr 2010; 4: (Full Text)
  14. Zhu CQ, Popova SN, Brown ER, Barsyte-Lovejoy D, Navab R, Shih W, Li M, Lu M, Jurisica I, Penn LZ, Gullberg D, Tsao MS. Integrin alpha 11 regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell lung cancer cells. Proc. Natl. Acad. Sci. U.S.A. 2007; 104:11754-9 (Full Text)
  15. Zutter MM, Edelson BT. The alpha2beta1 integrin: a novel collectin/C1q receptor. Immunobiology 2007; 212:343-53 (PubMed)
Consortium Results & Data
Discovery» siRNA migration screen using a wound healing approach
Gene Description     MCF-10A phenotype     Secondary screen Wound Image Morphology Time-lapse
ITGAV
Aliases: CD51, MSK8, VNRA
Entrez Gene: 3685
siRNA catalog
integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
mRNA: NM_002210
Library: MAR
Classification: integrin
Focal Adhesion Related: Yes
Final bin: Discordant
SMARTpool bin: No change
Avg area: 1.04
Avg Alamar: 0.94
Knockdown %: not done
  ITGAV
Link
ITGAV
Link
 
Discovery» siRNA Focal Adhesion Phenotypes
Gene Description High-Res Montage
ITGAV
Aliases: CD51, MSK8, VNRA
Entrez Gene: 3685
siRNA catalog
integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
mRNA: NM_002210
Library: MAR
ITGAV
Link
ITGAV
Link
Proteomics» Table 1. Identification and Quantitation of Proteins from Cell Body (CB) and Pseudopodium (PD) fractions
IPI Locus Description CB Spectra CB peptide PD Spectra PD peptide ratio
IPI00027505 ITGAV INTEGRIN ALPHA-V PRECURSOR. 5 4 24 11 4.80
Discovery» Drosophila Migration Genes
Gene Name Function Cell
Type
Phenotypes Reagents/
Alleles
Reference
if
Entrez: CG9623
Flybase: FBgn0001250
inflated cell adhesion molecule binding; receptor activity; protein binding embryonic trachea Loss of function: VB fail to migrate along VM
Autonomous: non-autonomous
Boube et al.,2001
embryonic endoderm Loss of function: Migration delay; alphaPS2 is expressed in the visceral mesoderm and the endodermal cells use VM as substrate for migration
Autonomous: autonomous
ifB4 Martin-Bermudo et al., 1999
Discovery» Drosophila Morphology Genes
Gene Name Cell Count/
Normalization
Stellate11
NumCorners
Stellate22
Binsum6
Non-Spreading3
CG9623
Entrez Gene: 32661
inflated
Aliases: alphaPS2 integrin; alpha integrin; position-specific antigen 2; alpha2 integrin; alpha[[PS2]] integrin; alpha-PS2-integrin
4.100
0.727
0.76 0.922 Actin: 0.98
Area: 1.117
Ratio: 0.877