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ITGA5 Orthologs

Aliases: integrin alpha 5, fibronectin receptor, alpha subunit, very late activation protein 5, alpha subunit, Fibronectin receptor subunit alpha, Integrin alpha-F, CD49 antigen-like family member E, Integrin alpha-5 heavy chain, Integrin alpha-5 light chain, FNRA, ITGA5, VLA-5, CD49e, VLA5A

Pfam Domain Structure

From ITGA5 (human)

Members of the ITGA5 ortholog set
Human Mouse Rat Chicken Fly Worm
CMKB ITGA5 Itga5 Itga5 - - -
Entrez Gene 3678 16402 315346 - - -
Uniprot ITA5_HUMAN ITA5_MOUSE - - - -
OMIM 135620 - - - - -
Reagents - 1 available - - - -
Results 3 available - - - - -
References
  1. Caswell PT, Vadrevu S, Norman JC. Integrins: masters and slaves of endocytic transport. Nat. Rev. Mol. Cell Biol. 2009; 10:843-53 (PubMed)
  2. Delon I, Brown NH. Integrins and the actin cytoskeleton. Curr. Opin. Cell Biol. 2007; 19:43-50 (PubMed)
  3. Eckes B, Zweers MC, Zhang ZG, Hallinger R, Mauch C, Aumailley M, Krieg T. Mechanical tension and integrin alpha 2 beta 1 regulate fibroblast functions. J. Investig. Dermatol. Symp. Proc. 2006; 11:66-72 (PubMed)
  4. Humphries JD, Byron A, Humphries MJ. Integrin ligands at a glance. J. Cell. Sci. 2006; 119:3901-3 (PubMed)
  5. Hynes RO. Integrins: bidirectional, allosteric signaling machines. Cell 2002; 110:673-87 (PubMed)
  6. Kim M, Carman CV, Springer TA. Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins. Science 2003; 301:1720-5 (PubMed)
  7. Luo BH, Carman CV, Springer TA. Structural basis of integrin regulation and signaling. Annu. Rev. Immunol. 2007; 25:619-47 (PubMed)
  8. Luo BH, Springer TA. Integrin structures and conformational signaling. Curr. Opin. Cell Biol. 2006; 18:579-86 (PubMed)
  9. Vicente-Manzanares M, Choi CK, Horwitz AR. Integrins in cell migration--the actin connection. J. Cell. Sci. 2009; 122:199-206 (PubMed)
  10. Wiesner S, Legate KR, Fässler R. Integrin-actin interactions. Cell. Mol. Life Sci. 2005; 62:1081-99 (PubMed)
  11. Zaidel-Bar R, Geiger B. The switchable integrin adhesome. J. Cell. Sci. 2010; 123:1385-8 (PubMed)
  12. Zaidel-Bar R, Itzkovitz S, Ma'ayan A, Iyengar R, Geiger B. Functional atlas of the integrin adhesome. Nat. Cell Biol. 2007; 9:858-67 (PubMed)
  13. Zargham R. Tensegrin in context: Dual role of alpha8 integrin in the migration of different cell types. Cell Adh Migr 2010; 4: (PubMed)
  14. Zhu CQ, Popova SN, Brown ER, Barsyte-Lovejoy D, Navab R, Shih W, Li M, Lu M, Jurisica I, Penn LZ, Gullberg D, Tsao MS. Integrin alpha 11 regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell lung cancer cells. Proc. Natl. Acad. Sci. U.S.A. 2007; 104:11754-9 (PubMed)
  15. Zutter MM, Edelson BT. The alpha2beta1 integrin: a novel collectin/C1q receptor. Immunobiology 2007; 212:343-53 (PubMed)
Consortium Results & Data
Discovery» siRNA migration screen using a wound healing approach
Gene Description     MCF-10A phenotype     Secondary screen Wound Image Morphology Time-lapse
ITGA5
Aliases: FNRA, CD49e, VLA5A
Entrez Gene: 3678
siRNA catalog 		integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
mRNA: NM_002205
Library: MAR
Classification: integrin
Focal Adhesion Related: Yes
 Final bin: Discordant
SMARTpool bin: Impaired *
Avg area: 1.82
Avg Alamar: 0.99
Knockdown %: not done
 ERBB2: No Change
 ITGA5
Link 		ITGA5
Link 		 
Discovery» siRNA Focal Adhesion Phenotypes
Gene Description High-Res Montage
ITGA5
Aliases: FNRA, CD49e, VLA5A
Entrez Gene: 3678
siRNA catalog 		integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
mRNA: NM_002205
Library: MAR
 ITGA5
Link 		ITGA5
Link
Proteomics» Table 1. Identification and Quantitation of Proteins from Cell Body (CB) and Pseudopodium (PD) fractions
IPI Locus Description CB Spectra CB peptide PD Spectra PD peptide ratio
IPI00306604 ITGA5 INTEGRIN ALPHA-5 PRECURSOR. 10 5 15 8 1.50
Consortium Related Products*
Mice » activity page
Ortholog Species Name Method Phenotype Status Jax Availability Source Publications
ITGA5 mouse Alpha-5 integrin Targeted - floxed
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 completed - mouse generated, evaluation in process Hynes
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* The resources presented here are largely those generated by the Consortium. The sidebar provides public databases that complement Consortium activities. For mice and biosensors, a public database is not available and therefore we have attempted to generate a migration related list for your convenience.