CRK Orthologs

Aliases: v-crk avian sarcoma virus CT10 oncogene homolog, v-crk sarcoma virus CT10 oncogene homolog, avian sarcoma virus CT10 (v-crk) oncogene homolog, CRKII, CRK

Processes & Diseases

Processes involved: adhesion

Pfam Domain Structure

From CRK (human)

Members of the CRK ortholog set
Human Mouse Rat Chicken Fly Worm
CMKB CRK Crk Crk CRK - -
Entrez Gene 1398 12928 54245 417553 - -
Uniprot CRK_HUMAN CRK_MOUSE CRK_RAT CRK_CHICK - -
OMIM 164762 - - - - -
Reagents - 1 available - - - -
Results 4 available - - - - -
References
  1. Cecchetti V, Tabarrini O, Sabatini S. From cromakalim to different structural classes of K(ATP) channel openers. Curr Top Med Chem 2006; 6:1049-68 (PubMed)
  2. Chodniewicz D, Klemke RL. Regulation of integrin-mediated cellular responses through assembly of a CAS/Crk scaffold. Biochim. Biophys. Acta 2004; 1692:63-76 (PubMed)
  3. Cipres A, Abassi YA, Vuori K. Abl functions as a negative regulator of Met-induced cell motility via phosphorylation of the adapter protein CrkII. Cell. Signal. 2007; 19:1662-70 (PubMed)
  4. Feller SM, Lewitzky M. Potential disease targets for drugs that disrupt protein-- protein interactions of Grb2 and Crk family adaptors. Curr. Pharm. Des. 2006; 12:529-48 (PubMed)
  5. Matsuda M, Ota S, Tanimura R, Nakamura H, Matuoka K, Takenawa T, Nagashima K, Kurata T. Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins. J. Biol. Chem. 1996; 271:14468-72 (PubMed)
Consortium Results & Data
Discovery» siRNA migration screen using a wound healing approach
Gene Description     MCF-10A phenotype     Secondary screen Wound Image Morphology Time-lapse
CRK
Aliases: CRKII
Entrez Gene: 1398
siRNA catalog
v-crk sarcoma virus CT10 oncogene homolog (avian)
mRNA: NM_005206
Library: MAR
Classification: adaptor
Focal Adhesion Related: Yes
Final bin: Impaired - HC
SMARTpool bin: Impaired
Avg area: 2.50
Avg Alamar: 0.82
Knockdown %: not done
ERBB2: No Change
CRK
Link
CRK
Link
Impaired E
CRK
Link
Discovery» siRNA Focal Adhesion Phenotypes
Gene Description High-Res Montage
CRK
Aliases: CRKII
Entrez Gene: 1398
siRNA catalog
v-crk sarcoma virus CT10 oncogene homolog (avian)
mRNA: NM_005206
Library: MAR
CRK
Link
CRK
Link
Proteomics» Table 1. Identification and Quantitation of Proteins from Cell Body (CB) and Pseudopodium (PD) fractions
IPI Locus Description CB Spectra CB peptide PD Spectra PD peptide ratio
IPI00305469 CRK CRK PROTEIN. 4 4 5 4 1.25
Proteomics» Table 2. Proteins in major organelles and subcellular compartments
IPI Locus Description CB Spectra PD Spectra ratio Location
IPI00305469 CRK CRK PROTEIN. 4 5 1.25 nucleus
Consortium Related Products*
Mice » activity page
Ortholog Species Name Method Phenotype Status Jax Availability Source Publications
CRK mouse Crk / Crk7
-
Elimination of Crk-II resulted in no obvious abnormalities. completed
-
-
Imaizumi et al.
Biosensors » activity page
Ortholog Species Name Type Source Publications
CRK none phospho-CrkII Intramolecular FRET between FPs - CFP-CrkII-YFP
-
Kurokawa et al.

* The resources presented here are largely those generated by the Consortium. The sidebar provides public databases that complement Consortium activities. For mice and biosensors, a public database is not available and therefore we have attempted to generate a migration related list for your convenience.

Pathways

How many degrees of interaction?

Update
Legend: Legend for CMKB pathways