CRK Orthologs

Aliases: v-crk avian sarcoma virus CT10 oncogene homolog, v-crk sarcoma virus CT10 oncogene homolog, avian sarcoma virus CT10 (v-crk) oncogene homolog, CRKII, CRK

Processes & Diseases

Processes involved: adhesion

Pfam Domain Structure

From CRK (human)

Members of the CRK ortholog set
Human Mouse Rat Chicken Fly Worm
CMKB CRK Crk Crk CRK - -
Entrez Gene 1398 12928 54245 417553 - -
Uniprot CRK_HUMAN CRK_MOUSE CRK_RAT CRK_CHICK - -
OMIM 164762 - - - - -
Reagents - 1 available - - - -
Results 4 available - - - - -
References
  1. Cecchetti V, Tabarrini O, Sabatini S. From cromakalim to different structural classes of K(ATP) channel openers. Curr Top Med Chem 2006; 6:1049-68 (PubMed)
  2. Chodniewicz D, Klemke RL. Regulation of integrin-mediated cellular responses through assembly of a CAS/Crk scaffold. Biochim. Biophys. Acta 2004; 1692:63-76 (PubMed)
  3. Cipres A, Abassi YA, Vuori K. Abl functions as a negative regulator of Met-induced cell motility via phosphorylation of the adapter protein CrkII. Cell. Signal. 2007; 19:1662-70 (PubMed)
  4. Feller SM, Lewitzky M. Potential disease targets for drugs that disrupt protein-- protein interactions of Grb2 and Crk family adaptors. Curr. Pharm. Des. 2006; 12:529-48 (PubMed)
  5. Matsuda M, Ota S, Tanimura R, Nakamura H, Matuoka K, Takenawa T, Nagashima K, Kurata T. Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins. J. Biol. Chem. 1996; 271:14468-72 (PubMed)
Consortium Results & Data

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Consortium Related Products*
Mice » activity page
Ortholog Species Name Method Phenotype Status Jax Availability Source Publications
CRK mouse Crk / Crk7
-
Elimination of Crk-II resulted in no obvious abnormalities. completed
-
-
Imaizumi et al.
Biosensors » activity page
Ortholog Species Name Type Source Publications
CRK none phospho-CrkII Intramolecular FRET between FPs - CFP-CrkII-YFP
-
Kurokawa et al.

* The resources presented here are largely those generated by the Consortium. The sidebar provides public databases that complement Consortium activities. For mice and biosensors, a public database is not available and therefore we have attempted to generate a migration related list for your convenience.

Pathways

How many degrees of interaction?

Update
Legend: Legend for CMKB pathways