DOCK1 Orthologs

Aliases: dedicator of cyto-kinesis 1, dedicator of cytokinesis 1, DOCK180, DOCK1, RP11-82L9.1, ced5

Processes & Diseases

Processes involved: adhesion

Pfam Domain Structure

From DOCK1 (human)

Members of the DOCK1 ortholog set
Human Mouse Rat Chicken Fly Worm
CMKB DOCK1 Dock1 Dock1 - mbc ced-5
Entrez Gene 1793 330662 309081 - 42817 177942
Uniprot DOCK1_HUMAN DOCK1_MOUSE - - - -
OMIM 601403 - - - - -
Reagents 1 available 1 available - - - -
Results 4 available - - - 3 available 1 available
References
  1. Côté JF, Vuori K. Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity. J. Cell. Sci. 2002; 115:4901-13 (PubMed)
  2. Grimsley CM, Kinchen JM, Tosello-Trampont AC, Brugnera E, Haney LB, Lu M, Chen Q, Klingele D, Hengartner MO, Ravichandran KS. Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration. J. Biol. Chem. 2004; 279:6087-97 (PubMed)
  3. Li W, Fan J, Woodley DT. Nck/Dock: an adapter between cell surface receptors and the actin cytoskeleton. Oncogene 2001; 20:6403-17 (PubMed)
  4. Lu M, Kinchen JM, Rossman KL, Grimsley C, Hall M, Sondek J, Hengartner MO, Yajnik V, Ravichandran KS. A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs. Curr. Biol. 2005; 15:371-7 (PubMed)
  5. Reif K, Cyster J. The CDM protein DOCK2 in lymphocyte migration. Trends Cell Biol. 2002; 12:368-73 (PubMed)
Consortium Results & Data
Results & Data
Ortholog Species Type Description Method Status Source Publications
DOCK1 none structure

PIP3 binding DHR1 domain of DOCK180

X-Ray crystallography

completed Liddington
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Discovery» Drosophila Morphology Genes
Gene Name Cell Count/
Normalization
Stellate11
NumCorners
Stellate22
Binsum6
Non-Spreading3
CG10379
Entrez Gene: 42817
myoblast city 11.250
1.449
0.837 0.93 Actin: 0.962
Area: 0.849
Ratio: 1.133

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Consortium Related Products*
Mice » activity page
Ortholog Species Name Method Phenotype Status Jax Availability Source Publications
DOCK1 mouse DOCK 180 Targeted - floxed and non-floxed
-
completed, publication in progress
-
Burds Laurin et al.
Constructs » activity page
Ortholog Species Targets Name Amino Acid Range Portion Protocol Source
DOCK1 human DOCK180 pGEX-6P2 154-256 DOCK180 DHR1 domain available Liddington

* The resources presented here are largely those generated by the Consortium. The sidebar provides public databases that complement Consortium activities. For mice and biosensors, a public database is not available and therefore we have attempted to generate a migration related list for your convenience.

Pathways

How many degrees of interaction?

Update
Legend: Legend for CMKB pathways