ARHGAP26 Orthologs

Aliases: GTPase regulator associated with focal adhesion kinase pp125(FAK), GTPase regulator associated with the focal adhesion kinase pp125, GTPase regulator associated with FAK, GRAF, ARHGAP26, FLJ42530, OPHN1L, OPHN1L1, KIAA0621

Pfam Domain Structure

From ARHGAP26 (human)

Members of the ARHGAP26 ortholog set
Human Mouse Rat Chicken Fly Worm
CMKB ARHGAP26 Arhgap26 Arhgap26 ARHGAP26 Graf T04C9.1
Entrez Gene 23092 71302 307459 396113 32522 175849
Uniprot RHG26_HUMAN - - - - -
OMIM 605370 - - - - -
Reagents - - - - - -
Results 2 available - - - 1 available -
References
  1. Aresta S, de Tand-Heim MF, BĂ©ranger F, de Gunzburg J. A novel Rho GTPase-activating-protein interacts with Gem, a member of the Ras superfamily of GTPases. Biochem. J. 2002; 367:57-65 (Full Text)
  2. Bernards A. GAPs galore! A survey of putative Ras superfamily GTPase activating proteins in man and Drosophila. Biochim. Biophys. Acta 2003; 1603:47-82 (PubMed)
  3. DerMardirossian C, Bokoch GM. GDIs: central regulatory molecules in Rho GTPase activation. Trends Cell Biol. 2005; 15:356-63 (PubMed)
  4. Kandpal RP. Rho GTPase activating proteins in cancer phenotypes. Curr. Protein Pept. Sci. 2006; 7:355-65 (PubMed)
  5. Moon SY, Zheng Y. Rho GTPase-activating proteins in cell regulation. Trends Cell Biol. 2003; 13:13-22 (PubMed)
Consortium Results & Data
Discovery» siRNA migration screen using a wound healing approach
Gene Description     MCF-10A phenotype     Secondary screen Wound Image Morphology Time-lapse
ARHGAP26
Aliases: GRAF, OPHN1L, OPHN1L1
Entrez Gene: 23092
siRNA catalog
Rho GTPase activating protein 26
mRNA: NM_015071
Library: MAR
Classification: GTPase regulator
Focal Adhesion Related: Yes
Final bin: Impaired - HC
SMARTpool bin: Impaired
Avg area: 2.85
Avg Alamar: 0.84
Knockdown %: not done
ERBB2: No Change
ARHGAP26
Link
ARHGAP26
Link
Impaired D
ARHGAP26
Link
Discovery» siRNA Focal Adhesion Phenotypes
Gene Description High-Res Montage
ARHGAP26
Aliases: GRAF, OPHN1L, OPHN1L1
Entrez Gene: 23092
siRNA catalog
Rho GTPase activating protein 26
mRNA: NM_015071
Library: MAR
ARHGAP26
Link
ARHGAP26
Link
Discovery» Drosophila Morphology Genes
Gene Name Cell Count/
Normalization
Stellate11
NumCorners
Stellate22
Binsum6
Non-Spreading3
CG8948
Entrez Gene: 32522
Graf 8.375
1.415
0.773 0.867 Actin: 1.138
Area: 0.957
Ratio: 1.189
CG8948
Entrez Gene: 32522
Graf 6.269
0.995
0.954 0.973 Actin: 1.109
Area: 0.963
Ratio: 1.152
Pathways

How many degrees of interaction?

Update
Legend: Legend for CMKB pathways