MAPK3 Orthologs

Aliases: mitogen-activated protein kinase 3, extracellular signal-related kinase 1, extracellular signal-regulated kinase 1, MGC20180, HS44KDAP, HUMKER1A, ERK1, MAPK3, PRKM3, P44ERK1, P44MAPK

Pfam Domain Structure

From MAPK3 (human)

Members of the MAPK3 ortholog set
Human Mouse Rat Chicken Fly Worm
CMKB MAPK3 Mapk3 Mapk3 - - -
Entrez Gene 5595 26417 50689 - - -
Uniprot MK03_HUMAN MK03_MOUSE MK03_RAT - - -
OMIM 601795 - - - - -
Reagents - - - - - -
Results 4 available 1 available - - - -
References
  1. Bode AM, Dong Z. The functional contrariety of JNK. Mol. Carcinog. 2007; 46:591-8 (Full Text)
  2. Borsello T, Forloni G. JNK signalling: a possible target to prevent neurodegeneration. Curr. Pharm. Des. 2007; 13:1875-86 (PubMed)
  3. Cook R, Wu CC, Kang YJ, Han J. The role of the p38 pathway in adaptive immunity. Cell. Mol. Immunol. 2007; 4:253-9 (PubMed)
  4. Dominguez C, Powers DA, Tamayo N. p38 MAP kinase inhibitors: many are made, but few are chosen. Curr Opin Drug Discov Devel 2005; 8:421-30 (PubMed)
  5. Meloche S, Pouysségur J. The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition. Oncogene 2007; 26:3227-39 (PubMed)
  6. Raman M, Chen W, Cobb MH. Differential regulation and properties of MAPKs. Oncogene 2007; 26:3100-12 (PubMed)
  7. Roberts OL, Holmes K, Müller J, Cross DA, Cross MJ. ERK5 and the regulation of endothelial cell function. Biochem. Soc. Trans. 2009; 37:1254-9 (PubMed)
  8. Roberts PJ, Der CJ. Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene 2007; 26:3291-310 (PubMed)
  9. Shaul YD, Seger R. The MEK/ERK cascade: from signaling specificity to diverse functions. Biochim. Biophys. Acta 2007; 1773:1213-26 (PubMed)
  10. Stains CI, Luković E, Imperiali B. A p38α-selective chemosensor for use in unfractionated cell lysates. ACS Chem. Biol. 2011; 6:101-5 (Full Text)
  11. Turjanski AG, Vaqué JP, Gutkind JS. MAP kinases and the control of nuclear events. Oncogene 2007; 26:3240-53 (PubMed)
  12. Wang Y. Mitogen-activated protein kinases in heart development and diseases. Circulation 2007; 116:1413-23 (PubMed)
Consortium Results & Data
Discovery» siRNA migration screen using a wound healing approach
Gene Description     MCF-10A phenotype     Secondary screen Wound Image Morphology Time-lapse
MAPK3
Aliases: ERK1, PRKM3, P44ERK1, P44MAPK, HS44KDAP, HUMKER1A
Entrez Gene: 5595
siRNA catalog
mitogen-activated protein kinase 3
mRNA: NM_002746
Library: Kinase
Classification: Ser/Thr Kinase
Final bin: Discordant
SMARTpool bin: Accelerated
Avg area: 0.65
Avg Alamar: 0.89
Knockdown %: 90-100
ERBB2: Accelerated
MAPK3
Link
MAPK3
Link
 
Discovery» siRNA Focal Adhesion Phenotypes
Gene Description High-Res Montage
MAPK3
Aliases: ERK1, PRKM3, P44ERK1, P44MAPK, HS44KDAP, HUMKER1A
Entrez Gene: 5595
siRNA catalog
mitogen-activated protein kinase 3
mRNA: NM_002746
Library: Kinase
MAPK3
Link
MAPK3
Link
Proteomics» Table 1. Identification and Quantitation of Proteins from Cell Body (CB) and Pseudopodium (PD) fractions
IPI Locus Description CB Spectra CB peptide PD Spectra PD peptide ratio
IPI00018195 MAPK3 MITOGEN-ACTIVATED PROTEIN KINASE 3. 17 10 13 6 0.76
Proteomics» Table 2. Proteins in major organelles and subcellular compartments
IPI Locus Description CB Spectra PD Spectra ratio Location
IPI00018195 MAPK3 MITOGEN-ACTIVATED PROTEIN KINASE 3. 17 13 0.76 nucleus
Discovery» MTLn3 invasive data
Gene mRNA Description Expression Ratio
Mapk3
Entrez Gene: 26417
mRNA: AW555779
UniGene: Mm.8385
Mitogen activated protein kinase 3 4.3
Consortium Related Products*
Biosensors » activity page
Ortholog Species Name Type Source Publications
MAPK3 none Erk Chelation-enhanced fluorophore Imperiali
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MAPK3 none Erk Chelation-enhanced fluorophore Imperiali
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MAPK3 none Erk Chelation-enhanced fluorophore - Test SOX-based Erk assay in living cells Imperiali
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MAPK3 none Erk - (Erk2) Affinity reagent for endogenous Erk2 - genetically encode FRET or environmentally sensitive dye Hahn Hodgson et al., Macnevin et al.

* The resources presented here are largely those generated by the Consortium. The sidebar provides public databases that complement Consortium activities. For mice and biosensors, a public database is not available and therefore we have attempted to generate a migration related list for your convenience.