PTK2 Orthologs

Aliases: focal adhesion kinase 1, Protein-tyrosine kinase 2, PTK2 protein tyrosine kinase 2, FAK, FADK 1, PTK2, FADK, FAK1, pp125FAK

Processes & Diseases

Processes involved: adhesion

Pfam Domain Structure

From PTK2 (chicken) - phosphorylation sites added via direct mapping

Members of the PTK2 ortholog set
Human Mouse Rat Chicken Fly Worm
CMKB PTK2 Ptk2 Ptk2 PTK2 Fak56D kin-32
Entrez Gene 5747 14083 25614 396416 37233 172135
Uniprot FAK1_HUMAN FAK1_MOUSE FAK1_RAT FAK1_CHICK - -
OMIM 600758 - - - - -
Reagents 2 available 4 available - - - -
Results 4 available 1 available - - 1 available -
References
  1. Cohen LA, Guan JL. Mechanisms of focal adhesion kinase regulation. Curr Cancer Drug Targets 2005; 5:629-43 (PubMed)
  2. Cox BD, Natarajan M, Stettner MR, Gladson CL. New concepts regarding focal adhesion kinase promotion of cell migration and proliferation. J. Cell. Biochem. 2006; 99:35-52 (PubMed)
  3. Lim ST, Mikolon D, Stupack DG, Schlaepfer DD. FERM control of FAK function: implications for cancer therapy. Cell Cycle 2008; 7:2306-14 (Full Text)
  4. Mitra SK, Schlaepfer DD. Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr. Opin. Cell Biol. 2006; 18:516-23 (PubMed)
  5. Mon NN, Ito S, Senga T, Hamaguchi M. FAK signaling in neoplastic disorders: a linkage between inflammation and cancer. Ann. N. Y. Acad. Sci. 2006; 1086:199-212 (PubMed)
  6. Parsons JT. Focal adhesion kinase: the first ten years. J. Cell. Sci. 2003; 116:1409-16 (PubMed)
  7. Schaller MD. FAK and paxillin: regulators of N-cadherin adhesion and inhibitors of cell migration?. J. Cell Biol. 2004; 166:157-9 (Full Text)
  8. Tomar A, Schlaepfer DD. Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility. Curr. Opin. Cell Biol. 2009; 21:676-83 (Full Text)
  9. Webb DJ, Donais K, Whitmore LA, Thomas SM, Turner CE, Parsons JT, Horwitz AF. FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly. Nat. Cell Biol. 2004; 6:154-61 (PubMed)
  10. Wozniak MA, Modzelewska K, Kwong L, Keely PJ. Focal adhesion regulation of cell behavior. Biochim. Biophys. Acta 2004; 1692:103-19 (PubMed)
  11. Xie Z, Tsai LH. Cdk5 phosphorylation of FAK regulates centrosome-associated miocrotubules and neuronal migration. Cell Cycle 2004; 3:108-10 (PubMed)
Consortium Results & Data
Results & Data
Ortholog Species Type Description Method Status Source Publications
PTK2 none phosphorylation site FAK Ectopic expression in HEK cells 18 phospho-sites in 80.2% coverage of 1045 aa Parsons Grigera et al.
PTK2 none structure

Paxillin (1-328)-FAT domain of FAK

NMR

completed Campbell
-
PTK2 none structure

Full-length FAK

X-Ray crystallography

completed Liddington
-
PTK2 none structure FAT domain of Focal Adhesion Kinase X-Ray crystallography, NMR data available Liddington Hayashi et al.
Discovery» Drosophila Morphology Genes
Gene Name Cell Count/
Normalization
Stellate11
NumCorners
Stellate22
Binsum6
Non-Spreading3
CG10023
Entrez Gene: 37233
Focal Adhesion Kinase 7.688
1.202
1.041 1.061 Actin: 0.978
Area: 0.91
Ratio: 1.075

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Consortium Related Products*
Mice » activity page
Ortholog Species Name Method Phenotype Status Jax Availability Source Publications
PTK2 mouse FAK / Cas - double knockout in embryonic fibroblasts
-
Defects in ephrinA1-induced cell spreading. completed
-
-
Carter et al.
PTK2 mouse Fak
-
Death at E8.5 with impaired blood vessel development. completed
-
-
Ilic et al.
PTK2 mouse FAK - embryonic fibroblasts
-
Reduced migration rate and an increase in the number and size of peripherally localized adhesions. completed
-
-
Ilić et al.
PTK2 mouse FAK
-
Elevated levels of Pyk2. completed
-
-
Sieg et al.
Constructs » activity page
Ortholog Species Targets Name Amino Acid Range Portion Protocol Source
PTK2 human FAK - soluble expression FAK-baculovirus 1-1052 FAK-full length
-
Liddington
PTK2 human FAK pT7-7-FAK 1-1052 FAK-full length available Liddington
Biosensors » activity page
Ortholog Species Name Type Source Publications
PTK2 none FAK Intermolecular FRET between FPs - CFP-FAK; dSH2 (Src)-YFP
-
Cai et al.
PTK2 none FAK Intramolecular FRET between FPs - Insertion of a FRET pair in FAK
-
Cai et al.
PTK2 none FAK FRET - single chain Hahn Cai et al.
Imaging Probes » activity page
Ortholog Species Name Type Status Source Publications
PTK2 none Photoactivation Fak/PTK2 - (caged phosphoTyr (Y*) - cPYFAK, probe sequence; VSETDDY*AEIIDEEDT-NH2) completed Imperiali, Jacobson Humphrey et al.

* The resources presented here are largely those generated by the Consortium. The sidebar provides public databases that complement Consortium activities. For mice and biosensors, a public database is not available and therefore we have attempted to generate a migration related list for your convenience.

Pathways

How many degrees of interaction?

Update
Legend: Legend for CMKB pathways