AKT1 Orthologs
Aliases: Murine thymoma viral (v-akt) oncogene homolog-1, v-akt murine thymoma viral oncogene homolog 1, protein kinase B, rac protein kinase alpha, RAC-alpha serine/threonine-protein kinase, RAC-PK-alpha, C-AKT, MGC99656, PKB-ALPHA, PKB, AKT1, AKT, RAC, PRKBA, RAC-ALPHA
Pfam Domain Structure
From AKT1 (human)
Members of the AKT1 ortholog set
| Human | Mouse | Rat | Chicken | Fly | Worm | |
| CMKB | AKT1 | Akt1 | Akt1 | AKT1 | - | akt-1 |
| Entrez Gene | 207 | 11651 | 24185 | 395928 | - | 179424 |
| Uniprot | AKT1_HUMAN | AKT1_MOUSE | AKT1_RAT | - | - | AKT1_CAEEL |
| OMIM | 164730 | - | - | - | - | - |
| Reagents | - | 1 available | - | - | - | - |
| Results | 4 available | - | - | - | - | - |
References
- Dillon RL, Muller WJ. Distinct biological roles for the akt family in mammary tumor progression. Cancer Res. 2010; 70:4260-4 (PubMed)
- Guirouilh-Barbat JK, Wilhelm T, Lopez BS. AKT1/BRCA1 in the control of homologous recombination and genetic stability: the missing link between hereditary and sporadic breast cancers. Oncotarget 2010; 1:691-9 (PubMed)
- Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell 2007; 129:1261-74 (PubMed)
- Roccaro AM, Sacco A, Husu EN, Pitsillides C, Vesole S, Azab AK, Azab F, Melhem M, Ngo HT, Quang P, Maiso P, Runnels J, Liang MC, Wong KK, Lin C, Ghobrial IM. Dual targeting of the PI3K/Akt/mTOR pathway as an antitumor strategy in Waldenstrom macroglobulinemia. Blood 2010; 115:559-69 (PubMed)
- Stambolic V, Woodgett JR. Functional distinctions of protein kinase B/Akt isoforms defined by their influence on cell migration. Trends Cell Biol. 2006; 16:461-6 (PubMed)
- Toker A, Yoeli-Lerner M. Akt signaling and cancer: surviving but not moving on. Cancer Res. 2006; 66:3963-6 (PubMed)
- Yang ZZ, Tschopp O, Baudry A, Dümmler B, Hynx D, Hemmings BA. Physiological functions of protein kinase B/Akt. Biochem. Soc. Trans. 2004; 32:350-4 (PubMed)
- Yoeli-Lerner M, Toker A. Akt/PKB signaling in cancer: a function in cell motility and invasion. Cell Cycle 2006; 5:603-5 (PubMed)
Consortium Results & Data
Discovery» siRNA migration screen using a wound healing approach
| Gene | Description | MCF-10A phenotype | Secondary screen | Wound Image | Morphology | Time-lapse |
|
AKT1 Aliases: AKT, PKB, RAC, PRKBA, RAC-ALPHA Entrez Gene: 207 siRNA catalog |
v-akt murine thymoma viral oncogene homolog 1 mRNA: NM_005163 Library: Kinase Classification: Ser/Thr Kinase Focal Adhesion Related: Yes |
Final bin: Impaired - HC SMARTpool bin: Impaired Avg area: 2.54 Avg Alamar: 0.81 Knockdown %: 70-80 |
ERBB2: No Change |
 Link |
 Link |
Impaired E Link |
Discovery» siRNA Focal Adhesion Phenotypes
| Gene | Description | High-Res | Montage |
|
AKT1 Aliases: AKT, PKB, RAC, PRKBA, RAC-ALPHA Entrez Gene: 207 siRNA catalog |
v-akt murine thymoma viral oncogene homolog 1 mRNA: NM_005163 Library: Kinase |
 Link |
 Link |
Proteomics» Table 1. Identification and Quantitation of Proteins from Cell Body (CB) and Pseudopodium (PD) fractions
| IPI | Locus | Description | CB Spectra | CB peptide | PD Spectra | PD peptide | ratio |
| IPI00012866 | AKT1 | RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE. | 5 | 3 | 10 | 5 | 2.00 |
Proteomics» Table 2. Proteins in major organelles and subcellular compartments
| IPI | Locus | Description | CB Spectra | PD Spectra | ratio | Location |
| IPI00012866 | AKT1 | RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE. | 5 | 10 | 2 | nucleus |
| IPI00012866 | AKT1 | RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE. | 5 | 10 | 2 | cytoskeleton |
Consortium Related Products*
Mice » activity page
| Ortholog | Species | Name | Method | Phenotype | Status | Jax Availability | Source | Publications |
|---|---|---|---|---|---|---|---|---|
| AKT1 | mouse | Akt1 (PKB-α) | - |
Partial lethality between E13.5 and 3 weeks after birth. Surviving adults are fertile, but show 20% weight reduction. No effect seen on glucose metabolism. | completed |
-
|
Cho et al. |
Biosensors » activity page
| Ortholog | Species | Name | Type | Source | Publications |
|---|---|---|---|---|---|
| AKT1 | none | Akt - PKB | Intramolecular FRET between FPs - CFP-14-3-3-substrate-YFP |
-
|
Sasaki et al. |
| AKT1 | none | Akt - PKB | Intramolecular FRET between FPs - CFP-FHA2-Akt substrate-YFP |
-
|
Kunkel et al. |
| AKT1 | none | Akt / PKA | Chelation-enhanced fluorophore | Imperiali |
-
|
* The resources presented here are largely those generated by the Consortium. The sidebar provides public databases that complement Consortium activities. For mice and biosensors, a public database is not available and therefore we have attempted to generate a migration related list for your convenience.
Pathways