LPXN human: leupaxin
Aliases: leupaxin, LPXN, LDPL
Pfam Domain Structure
From LPXN (human)
Protein Overview
| Official Gene Name | LPXN (H. sapiens) |
| RefSeq Protein Name | leupaxin |
| UniProt Gene Symbol | LPXN_HUMAN |
| UniProt Name | Leupaxin |
| Entrez Gene Summary | The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase activity. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
References
- Chen PW, Kroog GS. Leupaxin is similar to paxillin in focal adhesion targeting and tyrosine phosphorylation but has distinct roles in cell adhesion and spreading. Cell Adh Migr 2010; 4: (PubMed)
- Deakin NO, Turner CE. Paxillin comes of age. J. Cell. Sci. 2008; 121:2435-44 (PubMed)
- Hoefen RJ, Berk BC. The multifunctional GIT family of proteins. J. Cell. Sci. 2006; 119:1469-75 (PubMed)
- Huang C, Jacobson K, Schaller MD. A role for JNK-paxillin signaling in cell migration. Cell Cycle 2004; 3:4-6 (PubMed)
- Rathore VB, Okada M, Newman PJ, Newman DK. Paxillin family members function as Csk-binding proteins that regulate Lyn activity in human and murine platelets. Biochem. J. 2007; 403:275-81 (PubMed)
- Rose DM. The role of the alpha4 integrin-paxillin interaction in regulating leukocyte trafficking. Exp. Mol. Med. 2006; 38:191-5 (PubMed)
- Sabe H, Onodera Y, Mazaki Y, Hashimoto S. ArfGAP family proteins in cell adhesion, migration and tumor invasion. Curr. Opin. Cell Biol. 2006; 18:558-64 (PubMed)
- Schaller MD. FAK and paxillin: regulators of N-cadherin adhesion and inhibitors of cell migration?. J. Cell Biol. 2004; 166:157-9 (PubMed)
- Spinardi L, Marchisio PC. Podosomes as smart regulators of cellular adhesion. Eur. J. Cell Biol. 2006; 85:191-4 (PubMed)
- Webb DJ, Donais K, Whitmore LA, Thomas SM, Turner CE, Parsons JT, Horwitz AF. FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly. Nat. Cell Biol. 2004; 6:154-61 (PubMed)
Consortium Related Products*
Constructs » activity page
| Ortholog | Species | Targets | Name | Amino Acid Range | Portion | Protocol | Source |
|---|---|---|---|---|---|---|---|
| LPXN | human | Leupaxin | pET15b-leupaxin | 1-386 | Leupaxin -full length | - |
Ginsberg |
* The resources presented here are largely those generated by the Consortium. The sidebar provides public databases that complement Consortium activities. For mice and biosensors, a public database is not available and therefore we have attempted to generate a migration related list for your convenience.
Isoforms
| Isoform Name | RefSeq Protein | RefSeq mRNA | Swissprot ID |
|---|---|---|---|
| NP_004802 | NM_004811 | O60711 | |
| NP_001137467 | NM_001143995 | O60711 |
bold indicates the primary isoform
Pathways