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Cdk12 mouse: cyclin-dependent kinase 12

Aliases: CDC2-related protein kinase 7, Cdc2-related kinase, arginine/serine-rich, CDC2-related kinase 7, protein kinase for splicing component, MGC141525, D11Ertd752e, Pksc, RP23-333M1.3, AI646528, Crk7, CrkRS, 1810022J16Rik

Pfam Domain Structure

From Cdk12 (mouse)

Protein Overview
Official Gene Name Cdk12 (M. musculus)
RefSeq Protein Name cyclin-dependent kinase 12
UniProt Gene Symbol CDK12_MOUSE
UniProt Name Cell division cycle 2-related protein kinase 7
References
  1. Chen HH, Wang YC, Fann MJ. Identification and characterization of the CDK12/cyclin L1 complex involved in alternative splicing regulation. Mol. Cell. Biol. 2006; 26:2736-45 (PubMed)
  2. Ko TK, Kelly E, Pines J. CrkRS: a novel conserved Cdc2-related protein kinase that colocalises with SC35 speckles. J. Cell. Sci. 2001; 114:2591-603 (PubMed)
Consortium Results & Data
Discovery» siRNA migration screen using a wound healing approach
Gene Description     MCF-10A phenotype     Secondary screen Wound Image Morphology Time-lapse
CRKRS
Aliases: CRK7, CRKR
Entrez Gene: 51755
siRNA catalog 		Cdc2-related kinase, arginine/serine-rich
mRNA: NM_016507
Library: Kinase
Classification: Ser/Thr Kinase
 Final bin: Discordant
SMARTpool bin: No change
Avg area: 1.23
Avg Alamar: 0.91
Knockdown %: 70-80
   CRKRS
Link 		CRKRS
Link 		 
Discovery» siRNA Focal Adhesion Phenotypes
Gene Description High-Res Montage
CRKRS
Aliases: CRK7, CRKR
Entrez Gene: 51755
siRNA catalog 		Cdc2-related kinase, arginine/serine-rich
mRNA: NM_016507
Library: Kinase
 CRKRS
Link 		CRKRS
Link
Consortium Related Products*
Mice » activity page
Ortholog Species Name Method Phenotype Status Jax Availability Source Publications
CRKRS mouse Crk / Crk7
-
 Elimination of Crk-II resulted in no obvious abnormalities. completed
-
-
 Imaizumi et al.

* The resources presented here are largely those generated by the Consortium. The sidebar provides public databases that complement Consortium activities. For mice and biosensors, a public database is not available and therefore we have attempted to generate a migration related list for your convenience.

Isoforms
Isoform Name RefSeq Protein RefSeq mRNA Swissprot ID
NP_081228 NM_026952 Q14AX6-2
NP_001103096 NM_001109626 Q14AX6-1
NP_001103098 NM_001109628 Q14AX6-3

bold indicates the primary isoform