PIP5K1C chicken: phosphatidylinositol-4-phosphate 5-kinase, type I, gamma

Aliases: phosphatidylinositol-4-phosphate 5-kinase, type I, gamma, PIP5K1C

Protein Overview
Official Gene Name PIP5K1C (G. gallus)
RefSeq Protein Name phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
References
  1. Krauss M, Kukhtina V, Pechstein A, Haucke V. Stimulation of phosphatidylinositol kinase type I-mediated phosphatidylinositol (4,5)-bisphosphate synthesis by AP-2mu-cargo complexes. Proc. Natl. Acad. Sci. U.S.A. 2006; 103:11934-9 (PubMed)
  2. Ling K, Bairstow SF, Carbonara C, Turbin DA, Huntsman DG, Anderson RA. Type I gamma phosphatidylinositol phosphate kinase modulates adherens junction and E-cadherin trafficking via a direct interaction with mu 1B adaptin. J. Cell Biol. 2007; 176:343-53 (PubMed)
  3. Ling K, Doughman RL, Firestone AJ, Bunce MW, Anderson RA. Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions. Nature 2002; 420:89-93 (PubMed)
  4. Sun Y, Ling K, Wagoner MP, Anderson RA. Type I gamma phosphatidylinositol phosphate kinase is required for EGF-stimulated directional cell migration. J. Cell Biol. 2007; 178:297-308 (PubMed)
Consortium Results & Data
Results & Data
Ortholog Species Type Description Method Status Source Publications
PIP5K1C none structure PIPKIg -talin (196-400) X-Ray crystallography, NMR completed Liddington de Pereda et al.
Discovery» Drosophila Morphology Genes
Gene Name Cell Count/
Normalization
Stellate11
NumCorners
Stellate22
Binsum6
Non-Spreading3
CG3682
Entrez Gene: 37633
PIP5K59B 15.250
1.258
1.023 1.046 Actin: 0.957
Area: 0.986
Ratio: 0.971
Consortium Related Products*
Constructs » activity page
Ortholog Species Targets Name Amino Acid Range Portion Protocol Source
PIP5K1C human Talin / PIPKIg - soluble pET30a-talin 1-2541 Talin-full length, S429D gain-of-function mutant
-
Liddington
PIP5K1C human Talin / PIPKIg pET30b-talin rod 397-2541 Talin rod available Liddington
PIP5K1C human Talin / PIPKIg - soluble pET30a-talin 1-2541 Full length Talin available Liddington
PIP5K1C human Talin / PIPKIg pET151-DTOPO talin 196-889 196-889 Talin FERM F2F3 + part of rod available
-
PIP5K1C human Talin / PIPKIg - soluble pET30a-talin 1-2541 Talin-full length, S446D gain-of-function mutant
-
Liddington
PIP5K1C human Talin / PIPKIg - soluble pET30a-talin 1-2541 Talin-full length, S429D/S446D double gain-of-function mutant
-
Liddington
PIP5K1C human Talin / PIPKIg pGEX-4T-2 1984-2344 Talin VBS3
-
-
PIP5K1C human Talin / PIPKIg pET-29+ Talin Fragment G (L2094A/I12095A mutant)
-
-
PIP5K1C human Talin / PIPKIg pGEX-4T-2 2071-2135 Talin's actin-binding domain
-
-
PIP5K1C mouse Talin / PIPKIg - soluble/great yield pET15b-talin 482-636 482-636 Talin's Vinculin-binding domain (VBS1; 4-helix bundle) available Liddington
PIP5K1C mouse Talin / PIPKIg - soluble/great yield pET15b-talin 482-655 482-655 Talin's VBS1 (autoinhibited 5-helix bundle) available Liddington
PIP5K1C mouse Talin / PIPKIg - soluble/great yield pET15b-talin 482-789 482-789 Talin rod fragment available Liddington
PIP5K1C mouse Talin / PIPKIg - soluble/great yield pET151-DTOPO talin 482-889 482-889 Talin rod fragment available Liddington
PIP5K1C mouse Talin / PIPKIg - soluble/great yield pET151-DTOPO talin 482-889TTTT 482-889 Talin 482-889 stabilized fragment quadruple mutant (T775V/T809I/T833I/T867V) available Liddington
PIP5K1C mouse Talin / PIPKIg - soluble/great yield pET15b-talin 755-889 755-889 Talin's Vinculin-binding domain 2 (VBS2) available Liddington
PIP5K1C mouse Talin / PIPKIg - soluble/great yield pET15b-talin 1647-2541 1647-2541 Talin C-terminal fragment available Liddington
PIP5K1C mouse Talin / PIPKIg - soluble/good yield pET151-DTOPO talin 1843-1973 1843-1973 Talin VBS2 available Liddington
PIP5K1C chicken Talin / PIPKIg - soluble/great yield pET15b-His-F2F3short 209-400 Talin F2F3 fused to PIPKIgamma tail
-
Liddington
PIP5K1C chicken Talin / PIPKIg - soluble/ok yield pMAL-cgx-F3,4 309-405 Talin FERM F3 portion
-
Liddington
PIP5K1C chicken Talin / PIPKIg - low yield pET15b-His-F3 309-405 Talin FERM F3 portion available Liddington

* The resources presented here are largely those generated by the Consortium. The sidebar provides public databases that complement Consortium activities. For mice and biosensors, a public database is not available and therefore we have attempted to generate a migration related list for your convenience.

Isoforms
Isoform Name RefSeq Protein RefSeq mRNA Swissprot ID
XP_418191 XM_418191

bold indicates the primary isoform

Pathways

How many degrees of interaction?

Update
Legend: Legend for CMKB pathways