PIP5K1C chicken: phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
Aliases: phosphatidylinositol-4-phosphate 5-kinase, type I, gamma, PIP5K1C
Protein Overview
| Official Gene Name | PIP5K1C (G. gallus) |
| RefSeq Protein Name | phosphatidylinositol-4-phosphate 5-kinase, type I, gamma |
References
- Krauss M, Kukhtina V, Pechstein A, Haucke V. Stimulation of phosphatidylinositol kinase type I-mediated phosphatidylinositol (4,5)-bisphosphate synthesis by AP-2mu-cargo complexes. Proc. Natl. Acad. Sci. U.S.A. 2006; 103:11934-9 (PubMed)
- Ling K, Bairstow SF, Carbonara C, Turbin DA, Huntsman DG, Anderson RA. Type I gamma phosphatidylinositol phosphate kinase modulates adherens junction and E-cadherin trafficking via a direct interaction with mu 1B adaptin. J. Cell Biol. 2007; 176:343-53 (PubMed)
- Ling K, Doughman RL, Firestone AJ, Bunce MW, Anderson RA. Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions. Nature 2002; 420:89-93 (PubMed)
- Sun Y, Ling K, Wagoner MP, Anderson RA. Type I gamma phosphatidylinositol phosphate kinase is required for EGF-stimulated directional cell migration. J. Cell Biol. 2007; 178:297-308 (PubMed)
Consortium Results & Data
Results & Data
| Ortholog | Species | Type | Description | Method | Status | Source | Publications |
|---|---|---|---|---|---|---|---|
| PIP5K1C | none | structure | PIPKIg -talin (196-400) | X-Ray crystallography, NMR | completed | Liddington | de Pereda et al. |
Consortium Related Products*
Constructs » activity page
| Ortholog | Species | Targets | Name | Amino Acid Range | Portion | Protocol | Source |
|---|---|---|---|---|---|---|---|
| PIP5K1C | human | Talin / PIPKIg - soluble | pET30a-talin | 1-2541 | Talin-full length, S429D gain-of-function mutant | - |
Liddington |
| PIP5K1C | human | Talin / PIPKIg | pET30b-talin rod | 397-2541 | Talin rod | available | Liddington |
| PIP5K1C | human | Talin / PIPKIg - soluble | pET30a-talin | 1-2541 | Full length Talin | available | Liddington |
| PIP5K1C | human | Talin / PIPKIg | pET151-DTOPO talin 196-889 | 196-889 | Talin FERM F2F3 + part of rod | available |
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|
| PIP5K1C | human | Talin / PIPKIg - soluble | pET30a-talin | 1-2541 | Talin-full length, S446D gain-of-function mutant | - |
Liddington |
| PIP5K1C | human | Talin / PIPKIg - soluble | pET30a-talin | 1-2541 | Talin-full length, S429D/S446D double gain-of-function mutant | - |
Liddington |
| PIP5K1C | human | Talin / PIPKIg | pGEX-4T-2 | 1984-2344 | Talin VBS3 | - |
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|
| PIP5K1C | human | Talin / PIPKIg | pET-29+ | Talin Fragment G (L2094A/I12095A mutant) | - |
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|
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| PIP5K1C | human | Talin / PIPKIg | pGEX-4T-2 | 2071-2135 | Talin's actin-binding domain | - |
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|
| PIP5K1C | mouse | Talin / PIPKIg - soluble/great yield | pET15b-talin 482-636 | 482-636 | Talin's Vinculin-binding domain (VBS1; 4-helix bundle) | available | Liddington |
| PIP5K1C | mouse | Talin / PIPKIg - soluble/great yield | pET15b-talin 482-655 | 482-655 | Talin's VBS1 (autoinhibited 5-helix bundle) | available | Liddington |
| PIP5K1C | mouse | Talin / PIPKIg - soluble/great yield | pET15b-talin 482-789 | 482-789 | Talin rod fragment | available | Liddington |
| PIP5K1C | mouse | Talin / PIPKIg - soluble/great yield | pET151-DTOPO talin 482-889 | 482-889 | Talin rod fragment | available | Liddington |
| PIP5K1C | mouse | Talin / PIPKIg - soluble/great yield | pET151-DTOPO talin 482-889TTTT | 482-889 | Talin 482-889 stabilized fragment quadruple mutant (T775V/T809I/T833I/T867V) | available | Liddington |
| PIP5K1C | mouse | Talin / PIPKIg - soluble/great yield | pET15b-talin 755-889 | 755-889 | Talin's Vinculin-binding domain 2 (VBS2) | available | Liddington |
| PIP5K1C | mouse | Talin / PIPKIg - soluble/great yield | pET15b-talin 1647-2541 | 1647-2541 | Talin C-terminal fragment | available | Liddington |
| PIP5K1C | mouse | Talin / PIPKIg - soluble/good yield | pET151-DTOPO talin 1843-1973 | 1843-1973 | Talin VBS2 | available | Liddington |
| PIP5K1C | chicken | Talin / PIPKIg - soluble/great yield | pET15b-His-F2F3short | 209-400 | Talin F2F3 fused to PIPKIgamma tail | - |
Liddington |
| PIP5K1C | chicken | Talin / PIPKIg - soluble/ok yield | pMAL-cgx-F3,4 | 309-405 | Talin FERM F3 portion | - |
Liddington |
| PIP5K1C | chicken | Talin / PIPKIg - low yield | pET15b-His-F3 | 309-405 | Talin FERM F3 portion | available | Liddington |
* The resources presented here are largely those generated by the Consortium. The sidebar provides public databases that complement Consortium activities. For mice and biosensors, a public database is not available and therefore we have attempted to generate a migration related list for your convenience.
Isoforms
| Isoform Name | RefSeq Protein | RefSeq mRNA | Swissprot ID |
|---|---|---|---|
| XP_418191 | XM_418191 |
bold indicates the primary isoform
Pathways

