Layn mouse: layilin
Aliases: layilin, Gm511, Layn, E030012M19Rik
Pfam Domain Structure
From Layn (mouse)
Protein Overview
| Official Gene Name | Layn (M. musculus) |
| RefSeq Protein Name | layilin |
| UniProt Gene Symbol | LAYN_MOUSE |
References
- Bono P, Cordero E, Johnson K, Borowsky M, Ramesh V, Jacks T, Hynes RO. Layilin, a cell surface hyaluronan receptor, interacts with merlin and radixin. Exp. Cell Res. 2005; 308:177-87 (PubMed)
- Bono P, Rubin K, Higgins JM, Hynes RO. Layilin, a novel integral membrane protein, is a hyaluronan receptor. Mol. Biol. Cell 2001; 12:891-900 (PubMed)
- Chen Z, Zhuo W, Wang Y, Ao X, An J. Down-regulation of layilin, a novel hyaluronan receptor, via RNA interference, inhibits invasion and lymphatic metastasis of human lung A549 cells. Biotechnol. Appl. Biochem. 2008; 50:89-96 (PubMed)
- Zimmerman E, Geiger B, Addadi L. Initial stages of cell-matrix adhesion can be mediated and modulated by cell-surface hyaluronan. Biophys. J. 2002; 82:1848-57 (PubMed)
Consortium Results & Data
Results & Data
| Ortholog | Species | Type | Description | Method | Status | Source | Publications |
|---|---|---|---|---|---|---|---|
| LAYN | none | structure | Layilin-talin (196-400) | X-Ray crystallography, NMR | completed | Liddington | Wegener et al. |
Discovery» siRNA migration screen using a wound healing approach
| Gene | Description | MCF-10A phenotype | Secondary screen | Wound Image | Morphology | Time-lapse |
|
LAYN Entrez Gene: 143903 siRNA catalog |
layilin mRNA: NM_178834 Library: MAR Classification: other Focal Adhesion Related: Yes |
Final bin: No Phenotype SMARTpool bin: No change Avg area: 0.94 Avg Alamar: 0.93 Knockdown %: not done |
 Link |
 Link |
Discovery» siRNA Focal Adhesion Phenotypes
| Gene | Description | High-Res | Montage |
|
LAYN Entrez Gene: 143903 siRNA catalog |
layilin mRNA: NM_178834 Library: MAR |
 Link |
 Link |
Consortium Related Products*
Mice » activity page
| Ortholog | Species | Name | Method | Phenotype | Status | Jax Availability | Source | Publications |
|---|---|---|---|---|---|---|---|---|
| LAYN | human | Layilin | Targeted - nonfloxed | - |
completed - mouse generated, evaluation in process |
-
|
Hynes |
-
|
| LAYN | human | Layilin | Targeted - floxed | - |
completed - mouse generated, evaluation in process |
-
|
Hynes |
-
|
Constructs » activity page
| Ortholog | Species | Targets | Name | Amino Acid Range | Portion | Protocol | Source |
|---|---|---|---|---|---|---|---|
| LAYN | mouse | Layilin / Talin | pET15b-layilin | 207-400 | Layilin tail+talin F2+F3 fusion protein | - |
Liddington |
* The resources presented here are largely those generated by the Consortium. The sidebar provides public databases that complement Consortium activities. For mice and biosensors, a public database is not available and therefore we have attempted to generate a migration related list for your convenience.
Isoforms
| Isoform Name | RefSeq Protein | RefSeq mRNA | Swissprot ID |
|---|---|---|---|
| NP_001028706 | NM_001033534 | Q8C351 |
bold indicates the primary isoform