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Gsn mouse: gelsolin

Aliases: gelsolin, MGC28083, Gsn, RP23-186B18.2

Pfam Domain Structure

From Gsn (mouse)

Protein Overview
Official Gene Name Gsn (M. musculus)
RefSeq Protein Name gelsolin
UniProt Gene Symbol GELS_MOUSE
UniProt Name Gelsolin
References
  1. Silacci P, Mazzolai L, Gauci C, Stergiopulos N, Yin HL, Hayoz D. Gelsolin superfamily proteins: key regulators of cellular functions. Cell. Mol. Life Sci. 2004; 61:2614-23 (PubMed)
Consortium Results & Data
Discovery» siRNA migration screen using a wound healing approach
Gene Description     MCF-10A phenotype     Secondary screen Wound Image Morphology Time-lapse
GSN
Entrez Gene: 2934
siRNA catalog 		gelsolin (amyloidosis, Finnish type)
mRNA: NM_000177
Library: MAR
Classification: cytoskeletal
 Final bin: Discordant
SMARTpool bin: Low Alamar
Avg area: 1.96
Avg Alamar: 0.70
Knockdown %: not done
 ERBB2: No Change
BCL2: Low Alamar 		GSN
Link 		GSN
Link 		 
Discovery» siRNA Focal Adhesion Phenotypes
Gene Description High-Res Montage
GSN
Entrez Gene: 2934
siRNA catalog 		gelsolin (amyloidosis, Finnish type)
mRNA: NM_000177
Library: MAR
 GSN
Link 		GSN
Link
Proteomics» Table 1. Identification and Quantitation of Proteins from Cell Body (CB) and Pseudopodium (PD) fractions
IPI Locus Description CB Spectra CB peptide PD Spectra PD peptide ratio
IPI00026314 GSN GELSOLIN PRECURSOR. 27 11 42 13 1.56
Proteomics» Table 2. Proteins in major organelles and subcellular compartments
IPI Locus Description CB Spectra PD Spectra ratio Location
IPI00026314 GSN GELSOLIN PRECURSOR. 27 42 1.56 cytoskeleton
IPI00026314 GSN GELSOLIN PRECURSOR. 27 42 1.56 cytosol
Discovery» Drosophila Morphology Genes
Gene Name Cell Count/
Normalization 		Stellate11
NumCorners 		Stellate22
Binsum6 		Non-Spreading3
CG1106
Entrez Gene: 46008
 Gelsolin 10.929
1.985 		1.3 1.116 Actin: 1.18
Area: 0.893
Ratio: 1.321
Consortium Related Products*
Mice » activity page
Ortholog Species Name Method Phenotype Status Jax Availability Source Publications
GSN mouse Gelsolin - osteoclasts
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 Gelsolin deficiency blocks podosome assembly and alpha(v) beta(3) integrin-stimulated signaling, resulting in hypomotile osteoclasts due to the retarded remodeling of the actin cytoskeleton. completed
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-
 Chellaiah et al.
GSN mouse Gelsolin (ADF)
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 Gelsolin deficiency was associated with normal skeletal development and endochondral bone growth, but mildly abnormal epiphyseal structure, retained cartilage proteoglycans in metaphyseal trabeculae, and increased trabecular thickness. With age, gelsolin-deficient mice expressed increased trabecular and cortical bone thickness producing mechanically stronger bones. completed
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-
 Chellaiah et al.

* The resources presented here are largely those generated by the Consortium. The sidebar provides public databases that complement Consortium activities. For mice and biosensors, a public database is not available and therefore we have attempted to generate a migration related list for your convenience.

Isoforms
Isoform Name RefSeq Protein RefSeq mRNA Swissprot ID
NP_666232 NM_146120 P13020-1

bold indicates the primary isoform