Vim mouse: vimentin
Aliases: vimentin, Vim, RP23-185P20.1, MGC102095
Pfam Domain Structure
From Vim (mouse)
Protein Overview
| Official Gene Name | Vim (M. musculus) |
| RefSeq Protein Name | vimentin |
| UniProt Gene Symbol | VIME_MOUSE |
| UniProt Name | Vimentin |
References
- Esue O, Carson AA, Tseng Y, Wirtz D. A direct interaction between actin and vimentin filaments mediated by the tail domain of vimentin. J. Biol. Chem. 2006; 281:30393-9 (PubMed)
- Ivaska J, Pallari HM, Nevo J, Eriksson JE. Novel functions of vimentin in cell adhesion, migration, and signaling. Exp. Cell Res. 2007; 313:2050-62 (PubMed)
- Kumar N, Robidoux J, Daniel KW, Guzman G, Floering LM, Collins S. Requirement of vimentin filament assembly for beta3-adrenergic receptor activation of ERK MAP kinase and lipolysis. J. Biol. Chem. 2007; 282:9244-50 (PubMed)
- McInroy L, Määttä A. Down-regulation of vimentin expression inhibits carcinoma cell migration and adhesion. Biochem. Biophys. Res. Commun. 2007; 360:109-14 (PubMed)
- Minin AA, Moldaver MV. Intermediate vimentin filaments and their role in intracellular organelle distribution. Biochemistry Mosc. 2008; 73:1453-66 (PubMed)
- Nieminen M, Henttinen T, Merinen M, Marttila-Ichihara F, Eriksson JE, Jalkanen S. Vimentin function in lymphocyte adhesion and transcellular migration. Nat. Cell Biol. 2006; 8:156-62 (PubMed)
Consortium Results & Data
Discovery» PyMT invasive data
| Gene | mRNA | Description | Expression Ratio |
|
Vim Entrez Gene: 22352 |
mRNA: AW548722 UniGene: Mm.268000 |
Vimentin | 4.32 |
Discovery» siRNA migration screen using a wound healing approach
| Gene | Description | MCF-10A phenotype | Secondary screen | Wound Image | Morphology | Time-lapse |
|
VIM Entrez Gene: 7431 siRNA catalog |
vimentin mRNA: NM_003380 Library: MAR Classification: cytoskeletal Focal Adhesion Related: Yes |
Final bin: Impaired - HC SMARTpool bin: Impaired Avg area: 2.04 Avg Alamar: 0.86 Knockdown %: not done |
ERBB2: No Change |
 Link |
 Link |
Impaired E Link |
Discovery» siRNA Focal Adhesion Phenotypes
| Gene | Description | High-Res | Montage |
|
VIM Entrez Gene: 7431 siRNA catalog |
vimentin mRNA: NM_003380 Library: MAR |
 Link |
 Link |
Proteomics» Table 1. Identification and Quantitation of Proteins from Cell Body (CB) and Pseudopodium (PD) fractions
| IPI | Locus | Description | CB Spectra | CB peptide | PD Spectra | PD peptide | ratio |
| IPI00418471 | VIM | VIMENTIN. | 984 | 64 | 1861 | 78 | 1.89 |
Proteomics» Table 2. Proteins in major organelles and subcellular compartments
| IPI | Locus | Description | CB Spectra | PD Spectra | ratio | Location |
| IPI00418471 | VIM | VIMENTIN. | 984 | 1861 | 1.89 | cytoskeleton |
Proteomics» Table 3. Quantitation of phosphopeptides identified in Pseudopodium (PD) and Cell Body (CB) fractions
| IPI | Locus | Description | peptide | pdcb_p | pdcb_t | ratio | Mouse homology | Rat homology | Zebrafish homology | sd | Variable sites |
| IPI00418471 | VIM | VIMENTIN. | IS*LPLPNFSSLNLR | 2.79 | 1.89 | 1.48 | ++ | +++ | ++ | 0.12 | |
| IPI00418471 | VIM | VIMENTIN. | S*LYASSPGGVYATR | 2.33 | 1.89 | 1.23 | ++ | ++ | 0.05 |
Consortium Related Products*
Mice » activity page
| Ortholog | Species | Name | Method | Phenotype | Status | Jax Availability | Source | Publications |
|---|---|---|---|---|---|---|---|---|
| VIM | mouse | Vimentin | - |
No obvious phenotype. | completed |
-
|
-
|
Colucci-Guyon et al. |
| VIM | mouse | Vimentin | - |
Significant attenuation of flow-induced dilation of mesenteric resistance arteries perfused in vitro. | completed |
-
|
-
|
Henrion et al. |
* The resources presented here are largely those generated by the Consortium. The sidebar provides public databases that complement Consortium activities. For mice and biosensors, a public database is not available and therefore we have attempted to generate a migration related list for your convenience.
Isoforms
| Isoform Name | RefSeq Protein | RefSeq mRNA | Swissprot ID |
|---|---|---|---|
| NP_035831 | NM_011701 | P20152 |
bold indicates the primary isoform
Pathways