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Cblb mouse: Casitas B-lineage lymphoma b

Aliases: Casitas B-lineage lymphoma b, Cblb, AI429560, AI851073, Cbl-b

Pfam Domain Structure

From Cblb (mouse)

Protein Overview
Official Gene Name Cblb (M. musculus)
RefSeq Protein Name Casitas B-lineage lymphoma b
UniProt Gene Symbol CBLB_MOUSE
References
  1. Ardley HC, Robinson PA. E3 ubiquitin ligases. Essays Biochem. 2005; 41:15-30 (PubMed)
  2. Lee H, Gaughan JP, Tsygankov AY. c-Cbl facilitates cytoskeletal effects in v-Abl transformed fibroblast through Rac1- and Rap1-mediated signaling. Int. J. Biochem. Cell Biol. 2008; 40:1930-43 (PubMed)
  3. Rathinam C, Thien CB, Langdon WY, Gu H, Flavell RA. The E3 ubiquitin ligase c-Cbl restricts development and functions of hematopoietic stem cells. Genes Dev. 2008; 22:992-7 (PubMed)
  4. Rubin C, Gur G, Yarden Y. Negative regulation of receptor tyrosine kinases: unexpected links to c-Cbl and receptor ubiquitylation. Cell Res. 2005; 15:66-71 (PubMed)
  5. Swaminathan G, Feshchenko EA, Tsygankov AY. c-Cbl-facilitated cytoskeletal effects in v-Abl-transformed fibroblasts are regulated by membrane association of c-Cbl. Oncogene 2007; 26:4095-105 (PubMed)
  6. Swaminathan G, Tsygankov AY. The Cbl family proteins: ring leaders in regulation of cell signaling. J. Cell. Physiol. 2006; 209:21-43 (PubMed)
  7. Thien CB, Langdon WY. Negative regulation of PTK signalling by Cbl proteins. Growth Factors 2005; 23:161-7 (PubMed)
Consortium Related Products*
Mice » activity page
Ortholog Species Name Method Phenotype Status Jax Availability Source Publications
CBLB mouse Cbl-b
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 Viable and grossly normal. completed
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 Chiang et al.
CBLB mouse c-Cbl / Cbl-b - c-Cbl Cbl-b double knockout T cells
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 Hyper responsive upon anti-CD3 stimulation because the cells could not down-modulate surface TCR after ligand engagement. completed
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-
 Naramura et al.

* The resources presented here are largely those generated by the Consortium. The sidebar provides public databases that complement Consortium activities. For mice and biosensors, a public database is not available and therefore we have attempted to generate a migration related list for your convenience.

Isoforms
Isoform Name RefSeq Protein RefSeq mRNA Swissprot ID
NP_001028410 NM_001033238 Q3TTA7

bold indicates the primary isoform