Srf mouse: serum response factor
Aliases: serum response factor, Srf, AW049942, AW240594
Pfam Domain Structure
From Srf (mouse)
Protein Overview
| Official Gene Name | Srf (M. musculus) |
| RefSeq Protein Name | serum response factor |
| UniProt Gene Symbol | SRF_MOUSE |
| UniProt Name | Serum response factor |
References
- Cooper SJ, Trinklein ND, Nguyen L, Myers RM. Serum response factor binding sites differ in three human cell types. Genome Res. 2007; 17:136-44 (PubMed)
- Philippar U, Schratt G, Dieterich C, Müller JM, Galgóczy P, Engel FB, Keating MT, Gertler F, Schüle R, Vingron M, Nordheim A. The SRF target gene Fhl2 antagonizes RhoA/MAL-dependent activation of SRF. Mol. Cell 2004; 16:867-80 (PubMed)
Consortium Results & Data
Discovery» Drosophila Migration Genes
| Gene | Name | Function |
Cell Type |
Phenotypes |
Reagents/ Alleles |
Reference |
|
bs Entrez: CG3411 Flybase: FBgn0004101 |
blistered/SRF | transcription factor, serum response factor | larval trachea |
Loss of function: 3rd-instar larval supply defects Autonomous: autonomous Gain of function: NA Comments: terminal branch gene, homologue of mammalian SRF |
blisteredpruned1,FRT42B | Jarecki et. al.,Cell. 1999. 99(2):211-20. |
| embryonic trachea |
Loss of function: terminal branching abnormal Autonomous: autonomous |
bs14, 03267 | Fristrom 1994; Samakovlis 1996 | |||
| border cells |
Loss of function: incomplete border cell migration Autonomous: autonomous Gain of function: not reported Comments: works with Mal-d |
bs2R14, FRT | Somogyi 2004 |
Discovery» wt-migratory_cells vs wt-non-migratory_cells
| Symbol | Description | Median Values | Fold Change | Probe ID |
|
bs Flybase Entrez CMCKB |
blistered |
Mig: 85.4 Non-Mig: 134.9 |
0.63307 | 143424_at |
Discovery» Drosophila Morphology Genes
| Gene | Name |
Cell Count/ Normalization |
Stellate11 NumCorners |
Stellate22 Binsum6 |
Non-Spreading3 | |
|
CG3411 Entrez Gene: 37890 |
blistered Aliases: pruned; serum response factor; Serum Response Factor; balloon; Serum response factor; Drosophila serum response factor; Drosophila Serum Response Factor |
20.875 1.474 |
1.05 | 1.05 |
Actin: 1.052 Area: 0.631 Ratio: 1.667 |
|
Consortium Related Products*
Mice » activity page
| Ortholog | Species | Name | Method | Phenotype | Status | Jax Availability | Source | Publications |
|---|---|---|---|---|---|---|---|---|
| SRF | mouse | SRF - activated | Targeted at ROSA26 | - |
completed - mouse generated, evaluation in process |
-
|
Gertler |
-
|
* The resources presented here are largely those generated by the Consortium. The sidebar provides public databases that complement Consortium activities. For mice and biosensors, a public database is not available and therefore we have attempted to generate a migration related list for your convenience.