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Myh6 mouse: myosin, heavy polypeptide 6, cardiac muscle, alpha

Aliases: alpha myosin, myosin, heavy polypeptide 6, cardiac muscle, alpha, Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha), alpha cardiac MHC, cardiomyopathy, hypertrophic 1, myosin heavy chain, cardiac muscle, adult, alpha-MHC, Myhca, Myh6, MGC118706, Myhc-a, AA517445, A830009F23Rik

Pfam Domain Structure

From Myh6 (mouse)

Protein Overview
Official Gene Name Myh6 (M. musculus)
RefSeq Protein Name myosin, heavy polypeptide 6, cardiac muscle, alpha
UniProt Gene Symbol MYH6_MOUSE
UniProt Name Myosin-6
References
  1. Donaudy F, Snoeckx R, Pfister M, Zenner HP, Blin N, Di Stazio M, Ferrara A, Lanzara C, Ficarella R, Declau F, Pusch CM, Nürnberg P, Melchionda S, Zelante L, Ballana E, Estivill X, Van Camp G, Gasparini P, Savoia A. Nonmuscle myosin heavy-chain gene MYH14 is expressed in cochlea and mutated in patients affected by autosomal dominant hearing impairment (DFNA4). Am. J. Hum. Genet. 2004; 74:770-6 (PubMed)
  2. Eddinger TJ, Meer DP. Myosin II isoforms in smooth muscle: heterogeneity and function. Am. J. Physiol., Cell Physiol. 2007; 293:C493-508 (PubMed)
  3. O'Connell CB, Tyska MJ, Mooseker MS. Myosin at work: motor adaptations for a variety of cellular functions. Biochim. Biophys. Acta 2007; 1773:615-30 (PubMed)
  4. Redowicz MJ. Unconventional myosins in muscle. Eur. J. Cell Biol. 2007; 86:549-58 (PubMed)
  5. Sousa AD, Cheney RE. Myosin-X: a molecular motor at the cell's fingertips. Trends Cell Biol. 2005; 15:533-9 (PubMed)
  6. Svitkina TM, Verkhovsky AB, McQuade KM, Borisy GG. Analysis of the actin-myosin II system in fish epidermal keratocytes: mechanism of cell body translocation. J. Cell Biol. 1997; 139:397-415 (PubMed)
  7. Vicente-Manzanares M, Koach MA, Whitmore L, Lamers ML, Horwitz AF. Segregation and activation of myosin IIB creates a rear in migrating cells. J. Cell Biol. 2008; 183:543-54 (PubMed)
  8. Vicente-Manzanares M, Ma X, Adelstein RS, Horwitz AR. Non-muscle myosin II takes centre stage in cell adhesion and migration. Nat. Rev. Mol. Cell Biol. 2009; 10:778-90 (PubMed)
Consortium Related Products*
Mice » activity page
Ortholog Species Name Method Phenotype Status Jax Availability Source Publications
MYH6 mouse Cardiac alpha myosin, heavy chain
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 Dosage effects and functional deficits in the heart. completed
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 Jones et al.

* The resources presented here are largely those generated by the Consortium. The sidebar provides public databases that complement Consortium activities. For mice and biosensors, a public database is not available and therefore we have attempted to generate a migration related list for your convenience.

Isoforms
Isoform Name RefSeq Protein RefSeq mRNA Swissprot ID
NP_034986 NM_010856 Q02566
NP_001157643 NM_001164171 Q02566

bold indicates the primary isoform