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Itga4 mouse: integrin alpha 4

Aliases: integrin alpha 4, VLA-4 receptor, alpha 4 subunit, CD49D, Itga4, RP23-335P15.1

Pfam Domain Structure

From Itga4 (mouse)

Protein Overview
Official Gene Name Itga4 (M. musculus)
RefSeq Protein Name integrin alpha 4
UniProt Gene Symbol ITA4_MOUSE
References
  1. Caswell PT, Vadrevu S, Norman JC. Integrins: masters and slaves of endocytic transport. Nat. Rev. Mol. Cell Biol. 2009; 10:843-53 (PubMed)
  2. Delon I, Brown NH. Integrins and the actin cytoskeleton. Curr. Opin. Cell Biol. 2007; 19:43-50 (PubMed)
  3. Eckes B, Zweers MC, Zhang ZG, Hallinger R, Mauch C, Aumailley M, Krieg T. Mechanical tension and integrin alpha 2 beta 1 regulate fibroblast functions. J. Investig. Dermatol. Symp. Proc. 2006; 11:66-72 (PubMed)
  4. Humphries JD, Byron A, Humphries MJ. Integrin ligands at a glance. J. Cell. Sci. 2006; 119:3901-3 (PubMed)
  5. Hynes RO. Integrins: bidirectional, allosteric signaling machines. Cell 2002; 110:673-87 (PubMed)
  6. Kim M, Carman CV, Springer TA. Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins. Science 2003; 301:1720-5 (PubMed)
  7. Luo BH, Carman CV, Springer TA. Structural basis of integrin regulation and signaling. Annu. Rev. Immunol. 2007; 25:619-47 (PubMed)
  8. Luo BH, Springer TA. Integrin structures and conformational signaling. Curr. Opin. Cell Biol. 2006; 18:579-86 (PubMed)
  9. Vicente-Manzanares M, Choi CK, Horwitz AR. Integrins in cell migration--the actin connection. J. Cell. Sci. 2009; 122:199-206 (PubMed)
  10. Wiesner S, Legate KR, Fässler R. Integrin-actin interactions. Cell. Mol. Life Sci. 2005; 62:1081-99 (PubMed)
  11. Zaidel-Bar R, Geiger B. The switchable integrin adhesome. J. Cell. Sci. 2010; 123:1385-8 (PubMed)
  12. Zaidel-Bar R, Itzkovitz S, Ma'ayan A, Iyengar R, Geiger B. Functional atlas of the integrin adhesome. Nat. Cell Biol. 2007; 9:858-67 (PubMed)
  13. Zargham R. Tensegrin in context: Dual role of alpha8 integrin in the migration of different cell types. Cell Adh Migr 2010; 4: (PubMed)
  14. Zhu CQ, Popova SN, Brown ER, Barsyte-Lovejoy D, Navab R, Shih W, Li M, Lu M, Jurisica I, Penn LZ, Gullberg D, Tsao MS. Integrin alpha 11 regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell lung cancer cells. Proc. Natl. Acad. Sci. U.S.A. 2007; 104:11754-9 (PubMed)
  15. Zutter MM, Edelson BT. The alpha2beta1 integrin: a novel collectin/C1q receptor. Immunobiology 2007; 212:343-53 (PubMed)
Consortium Results & Data
Discovery» siRNA migration screen using a wound healing approach
Gene Description     MCF-10A phenotype     Secondary screen Wound Image Morphology Time-lapse
ITGA4
Aliases: IA4, CD49D
Entrez Gene: 3676
siRNA catalog 		integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
mRNA: NM_000885
Library: MAR
Classification: integrin
 Final bin: No Phenotype
SMARTpool bin: No change
Avg area: 0.75
Avg Alamar: 1.09
Knockdown %: not done
   ITGA4
Link 		ITGA4
Link 		 
Discovery» siRNA Focal Adhesion Phenotypes
Gene Description High-Res Montage
ITGA4
Aliases: IA4, CD49D
Entrez Gene: 3676
siRNA catalog 		integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
mRNA: NM_000885
Library: MAR
 ITGA4
Link 		ITGA4
Link
Consortium Related Products*
Mice » activity page
Ortholog Species Name Method Phenotype Status Jax Availability Source Publications
ITGA4 mouse Alpha-4 integrin - (Ser1021Ala) Targeted - floxed
-
 completed - mouse generated, evaluation in process Ginsberg
-
Biosensors » activity page
Ortholog Species Name Type Source Publications
ITGA4 none α4 Intermolecular FRET between fluorescent dyes - LDV-FITC; octadecyl rhodamine B
-
 Chigaev et al.

* The resources presented here are largely those generated by the Consortium. The sidebar provides public databases that complement Consortium activities. For mice and biosensors, a public database is not available and therefore we have attempted to generate a migration related list for your convenience.

Isoforms
Isoform Name RefSeq Protein RefSeq mRNA Swissprot ID
NP_034706 NM_010576 Q00651

bold indicates the primary isoform