Fhl2 mouse: four and a half LIM domains 2
Aliases: four and a half LIM domains 2, Skeletal muscle LIM-protein 3, SLIM3, Fhl2, C76204, FHL-2, SLIM 3
Pfam Domain Structure
From Fhl2 (mouse)
Protein Overview
| Official Gene Name | Fhl2 (M. musculus) |
| RefSeq Protein Name | four and a half LIM domains 2 |
| UniProt Gene Symbol | FHL2_MOUSE |
| UniProt Name | Four and a half LIM domains protein 2 |
References
- Canault M, Tellier E, Bonardo B, Mas E, Aumailley M, Juhan-Vague I, Nalbone G, Peiretti F. FHL2 interacts with both ADAM-17 and the cytoskeleton and regulates ADAM-17 localization and activity. J. Cell. Physiol. 2006; 208:363-72 (PubMed)
- Gabriel B, Mildenberger S, Weisser CW, Metzger E, Gitsch G, Schüle R, Müller JM. Focal adhesion kinase interacts with the transcriptional coactivator FHL2 and both are overexpressed in epithelial ovarian cancer. Anticancer Res. 2004; 24:921-7 (PubMed)
- Johannessen M, Møller S, Hansen T, Moens U, Van Ghelue M. The multifunctional roles of the four-and-a-half-LIM only protein FHL2. Cell. Mol. Life Sci. 2006; 63:268-84 (PubMed)
- Kleiber K, Strebhardt K, Martin BT. The biological relevance of FHL2 in tumour cells and its role as a putative cancer target. Anticancer Res. 2007; 27:55-61 (PubMed)
- Park J, Will C, Martin B, Gullotti L, Friedrichs N, Buettner R, Schneider H, Ludwig S, Wixler V. Deficiency in the LIM-only protein FHL2 impairs assembly of extracellular matrix proteins. FASEB J. 2008; 22:2508-20 (PubMed)
Consortium Results & Data
Discovery» siRNA migration screen using a wound healing approach
| Gene | Description | MCF-10A phenotype | Secondary screen | Wound Image | Morphology | Time-lapse |
|
FHL2 Aliases: DRAL, AAG11, SLIM3 Entrez Gene: 2274 siRNA catalog |
four and a half LIM domains 2 mRNA: NM_001450 Library: MAR Classification: other Focal Adhesion Related: Yes |
Final bin: Discordant SMARTpool bin: No change Avg area: 2.00 Avg Alamar: 0.88 Knockdown %: not done |
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Discovery» siRNA Focal Adhesion Phenotypes
| Gene | Description | High-Res | Montage |
|
FHL2 Aliases: DRAL, AAG11, SLIM3 Entrez Gene: 2274 siRNA catalog |
four and a half LIM domains 2 mRNA: NM_001450 Library: MAR |
 Link |
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Proteomics» Table 1. Identification and Quantitation of Proteins from Cell Body (CB) and Pseudopodium (PD) fractions
| IPI | Locus | Description | CB Spectra | CB peptide | PD Spectra | PD peptide | ratio |
| IPI00396967 | FHL2 | FOUR AND A HALF LIM DOMAINS 2 ISOFORM 1 . | 10 | 5 | 15 | 9 | 1.50 |
Proteomics» Table 2. Proteins in major organelles and subcellular compartments
| IPI | Locus | Description | CB Spectra | PD Spectra | ratio | Location |
| IPI00396967 | FHL2 | FOUR AND A HALF LIM DOMAINS 2 ISOFORM 1 . | 10 | 15 | 1.5 | nucleus |
Consortium Related Products*
Mice » activity page
| Ortholog | Species | Name | Method | Phenotype | Status | Jax Availability | Source | Publications |
|---|---|---|---|---|---|---|---|---|
| FHL2 | mouse | DRAL (FHL2) | - |
Viable, grossly normal. Null animals have an exaggerated hypertrophic response to beta-adrenergic stimulation. | completed |
-
|
-
|
Kong et al. |
| FHL2 | mouse | DRAL (FHL2) | - |
Viable, grossly normal. Normal cardiac development, and no increase in FHL1 or FHL3 mRNA. | completed |
-
|
-
|
Chu et al. |
* The resources presented here are largely those generated by the Consortium. The sidebar provides public databases that complement Consortium activities. For mice and biosensors, a public database is not available and therefore we have attempted to generate a migration related list for your convenience.
Isoforms
| Isoform Name | RefSeq Protein | RefSeq mRNA | Swissprot ID |
|---|---|---|---|
| NP_034342 | NM_010212 | O70433 |
bold indicates the primary isoform
Pathways