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Enah mouse: enabled homolog (Drosophila)

Aliases: NPC derived proline rich protein 1, enabled homolog, NDPP-1, AI464316, AW045240, Mena, Enah, WBP8, Ndpp1

Pfam Domain Structure

From Enah (mouse)

Protein Overview
Official Gene Name Enah (M. musculus)
RefSeq Protein Name enabled homolog (Drosophila)
UniProt Gene Symbol ENAH_MOUSE
UniProt Name Protein enabled homolog
References
  1. Bear JE, Gertler FB. Ena/VASP: towards resolving a pointed controversy at the barbed end. J. Cell. Sci. 2009; 122:1947-53 (PubMed)
  2. Bear JE, Svitkina TM, Krause M, Schafer DA, Loureiro JJ, Strasser GA, Maly IV, Chaga OY, Cooper JA, Borisy GG, Gertler FB. Antagonism between Ena/VASP proteins and actin filament capping regulates fibroblast motility. Cell 2002; 109:509-21 (PubMed)
  3. Drees F, Gertler FB. Ena/VASP: proteins at the tip of the nervous system. Curr. Opin. Neurobiol. 2008; 18:53-9 (PubMed)
  4. Mejillano MR, Kojima S, Applewhite DA, Gertler FB, Svitkina TM, Borisy GG. Lamellipodial versus filopodial mode of the actin nanomachinery: pivotal role of the filament barbed end. Cell 2004; 118:363-73 (PubMed)
  5. Otey CA, Rachlin A, Moza M, Arneman D, Carpen O. The palladin/myotilin/myopalladin family of actin-associated scaffolds. Int. Rev. Cytol. 2005; 246:31-58 (PubMed)
  6. Schirenbeck A, Arasada R, Bretschneider T, Schleicher M, Faix J. Formins and VASPs may co-operate in the formation of filopodia. Biochem. Soc. Trans. 2005; 33:1256-9 (PubMed)
  7. Sechi AS, Wehland J. ENA/VASP proteins: multifunctional regulators of actin cytoskeleton dynamics. Front. Biosci. 2004; 9:1294-310 (PubMed)
  8. Spinardi L, Marchisio PC. Podosomes as smart regulators of cellular adhesion. Eur. J. Cell Biol. 2006; 85:191-4 (PubMed)
  9. Urbanelli L, Massini C, Emiliani C, Orlacchio A, Bernardi G, Orlacchio A. Characterization of human Enah gene. Biochim. Biophys. Acta 2006; 1759:99-107 (PubMed)
Consortium Results & Data
Discovery» wt-migratory_cells vs wt-non-migratory_cells
Symbol Description Median Values Fold Change Probe ID
enb
Flybase
Entrez
CMCKB
 enabled Mig: 121.9
Non-Mig: 117.3
 1.03920 154185_at
Consortium Related Products*
Mice » activity page
Ortholog Species Name Method Phenotype Status Jax Availability Source Publications
Enah mouse Ena / VASP / Evl - triple neurons
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 Neuritogenesis in Ena/VASP-null neurons can be rescued by restoring filopodia formation through addition of laminin or expression of actin nucleating protein mDia2. completed
-
-
 Dent et al.
Enah mouse Ena / VASP / Evl - triple chimera
-
 Neuronal ectopias, altered intralayer positioning in the cortical plate, and no axon fiber tract formation during corticogenesis. completed
-
-
 Kwiatkowski et al.
Enah mouse Mena
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 Viable, with misrouted axons, failed decussation of the corpus callosum, and defects in both the hippocampal commissure and the pontocerebellar pathway. completed
-
-
 Lanier et al.
Enah mouse VASP / Ena - double
-
 Review completed
-
-
 Bear et al.
Enah mouse VASP / Ena - double
-
 Embryonic Lethal completed
-
-
 Goh et al.
Enah mouse Mena / VASP / Evl - triple null ES cell lines
-
 completed - lines available
-
 Gertler Dent et al., Kwiatkowski et al.
Enah mouse mEna Targeted - floxed
-
 completed - mouse generated, evaluation in process
-
 Gertler
-

* The resources presented here are largely those generated by the Consortium. The sidebar provides public databases that complement Consortium activities. For mice and biosensors, a public database is not available and therefore we have attempted to generate a migration related list for your convenience.

Isoforms
Isoform Name RefSeq Protein RefSeq mRNA Swissprot ID
isoform 1 NP_034265 NM_010135 Q03173-1
isoform 3 NP_001076589 NM_001083120 Q03173
isoform 4 NP_001076590 NM_001083121 Q03173-3
isoform 2 NP_032706 NM_008680 Q03173

bold indicates the primary isoform