Grb2 Family

Aliases: growth factor receptor-bound protein 2, SH2/SH3 adapter GRB2, Protein Ash, HT027, Adapter protein GRB2, abundant SRC homology, growth factor receptor-bound protein 3, epidermal growth factor receptor-binding protein GRB2, GRB2, MSTP084, NCKAP2, ASH, MST084, Grb3-3, EGFRBP-GRB2

Pfam Domain Structure

From GRB2 (human)

Members of the Grb2 Family
1: GRB2 » Human Mouse Rat Chicken Fly Worm
CMKB GRB2 Grb2 Grb2 GRB2 drk sem-5
Entrez Gene 2885 14784 81504 386572 36497 181055
Uniprot GRB2_HUMAN GRB2_MOUSE GRB2_RAT GRB2_CHICK DRK_DROME SEM5_CAEEL
OMIM 108355 - - - - -
Reagents - 2 available - - - -
Results 5 available - - - 3 available -
Family Summary

Grb2 is an adaptor protein with N- and C-terminal src homology 3 (SH3) domains and a central src homology 2 (SH2) domain. The SH2 domain can bind to phosphoTyr residues of receptors or other adaptor proteins, such as SHC. The SH3 domains bind the Ras exchange factor SOS, but can also bind to other adaptor proteins such as GAB1 and GAB2. Thus, Grb-2 is involved in activation of Ras but can also play a role in other signaling pathways in mammalian cells.

References
  1. Dharmawardana PG, Peruzzi B, Giubellino A, Burke TR, Bottaro DP. Molecular targeting of growth factor receptor-bound 2 (Grb2) as an anti-cancer strategy. Anticancer Drugs 2006; 17:13-20 (PubMed)
  2. Feller SM, Lewitzky M. Potential disease targets for drugs that disrupt protein-- protein interactions of Grb2 and Crk family adaptors. Curr. Pharm. Des. 2006; 12:529-48 (PubMed)
  3. Johannessen LE, Pedersen NM, Pedersen KW, Madshus IH, Stang E. Activation of the epidermal growth factor (EGF) receptor induces formation of EGF receptor- and Grb2-containing clathrin-coated pits. Mol. Cell. Biol. 2006; 26:389-401 (Full Text)
  4. Natarajan K, Berk BC. Crosstalk coregulation mechanisms of G protein-coupled receptors and receptor tyrosine kinases. Methods Mol. Biol. 2006; 332:51-77 (PubMed)
  5. Sármay G, Angyal A, Kertész A, Maus M, Medgyesi D. The multiple function of Grb2 associated binder (Gab) adaptor/scaffolding protein in immune cell signaling. Immunol. Lett. 2006; 104:76-82 (PubMed)
  6. Zarich N, Oliva JL, Martínez N, Jorge R, Ballester A, Gutiérrez-Eisman S, García-Vargas S, Rojas JM. Grb2 is a negative modulator of the intrinsic Ras-GEF activity of hSos1. Mol. Biol. Cell 2006; 17:3591-7 (Full Text)
Consortium Results & Data

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Discovery» Drosophila Morphology Genes
Gene Name Cell Count/
Normalization
Stellate11
NumCorners
Stellate22
Binsum6
Non-Spreading3
CG6033
Entrez Gene: 36497
downstream of receptor kinase
Aliases: Enhancer of sevenless-2B; downstream receptor kinase
5.688
1.129
1.173 1.026 Actin: 0.849
Area: 1.129
Ratio: 0.752

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Apache/2.2.15 (Red Hat) Server at www.cellmigration.org Port 80

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Apache/2.2.15 (Red Hat) Server at www.cellmigration.org Port 80

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Consortium Related Products*
Mice » activity page
Ortholog Species Name Method Phenotype Status Jax Availability Source Publications
GRB2 mouse Grb2 - hypomorph
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Perinatal death due to cleft palate. completed
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Saxton et al.
GRB2 mouse Grb2
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Embryonic lethality at E4. Failure in endoderm differentiation. Chimeric embryos show that Grb2-null cells do not contribute to the epiblast. completed
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Saxton et al., Cheng et al.

* The resources presented here are largely those generated by the Consortium. The sidebar provides public databases that complement Consortium activities. For mice and biosensors, a public database is not available and therefore we have attempted to generate a migration related list for your convenience.

The primary classification of CMKB families is the homeomorphic family, whose members are both homologous (evolved from a common ancestor) and homeomorphic (sharing full-length sequence similarity and a common domain architecture).