Src Family

Aliases: tyrosine kinase pp60c-src, proto-oncogene tyrosine-protein kinase SRC, tyrosine-protein kinase SRC-1, protooncogene SRC, Rous sarcoma, ASV, SRC, SRC1, c-SRC, p60-Src

Processes & Diseases

Processes involved: adhesion

Pfam Domain Structure

From SRC (human)

Members of the Src Family
1: SRC » Human Mouse Rat Chicken Fly Worm
CMKB SRC Src Src SRC Src64B -
Entrez Gene 6714 20779 83805 396442 48973 -
Uniprot SRC_HUMAN SRC_MOUSE SRC_RAT SRC_CHICK SRC64_DROME -
OMIM 190090 - - - - -
Reagents - 2 available - - - -
Results 3 available - - - 2 available -
Family Summary

Src (c-Src) is highly similar to the v-src gene of Rous sarcoma virus, and is a non-receptor tyrosine kinase with oncogenic potential. The encoded protein is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase.

References
  1. Alvarez RH, Kantarjian HM, Cortes JE. The role of Src in solid and hematologic malignancies: development of new-generation Src inhibitors. Cancer 2006; 107:1918-29 (PubMed)
  2. Berton G, M├│csai A, Lowell CA. Src and Syk kinases: key regulators of phagocytic cell activation. Trends Immunol. 2005; 26:208-14 (PubMed)
  3. Bromann PA, Korkaya H, Courtneidge SA. The interplay between Src family kinases and receptor tyrosine kinases. Oncogene 2004; 23:7957-68 (PubMed)
  4. Guarino M. Src signaling in cancer invasion. J. Cell. Physiol. 2010; 223:14-26 (PubMed)
  5. Homsi J, Cubitt C, Daud A. The Src signaling pathway: a potential target in melanoma and other malignancies. Expert Opin. Ther. Targets 2007; 11:91-100 (PubMed)
  6. Lee G. Tau and src family tyrosine kinases. Biochim. Biophys. Acta 2005; 1739:323-30 (PubMed)
  7. Levin VA. Basis and importance of Src as a target in cancer. Cancer Treat. Res. 2004; 119:89-119 (PubMed)
  8. Li S, Shang Y. Regulation of SRC family coactivators by post-translational modifications. Cell. Signal. 2007; 19:1101-12 (PubMed)
  9. Martin GS. The road to Src. Oncogene 2004; 23:7910-7 (PubMed)
  10. Mitra SK, Schlaepfer DD. Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr. Opin. Cell Biol. 2006; 18:516-23 (PubMed)
  11. Natarajan K, Yin G, Berk BC. Scaffolds direct Src-specific signaling in response to angiotensin II: new roles for Cas and GIT1. Mol. Pharmacol. 2004; 65:822-5 (PubMed)
  12. Parsons SJ, Parsons JT. Src family kinases, key regulators of signal transduction. Oncogene 2004; 23:7906-9 (PubMed)
  13. Playford MP, Schaller MD. The interplay between Src and integrins in normal and tumor biology. Oncogene 2004; 23:7928-46 (PubMed)
  14. Roskoski R. Src kinase regulation by phosphorylation and dephosphorylation. Biochem. Biophys. Res. Commun. 2005; 331:1-14 (PubMed)
  15. Silva CM. Role of STATs as downstream signal transducers in Src family kinase-mediated tumorigenesis. Oncogene 2004; 23:8017-23 (PubMed)
  16. Webb DJ, Donais K, Whitmore LA, Thomas SM, Turner CE, Parsons JT, Horwitz AF. FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly. Nat. Cell Biol. 2004; 6:154-61 (PubMed)
  17. Yeatman TJ. A renaissance for SRC. Nat. Rev. Cancer 2004; 4:470-80 (PubMed)
Consortium Results & Data
Results & Data
Ortholog Species Type Description Method Status Source Publications
SRC none structure

Beta 3-Src SH3

NMR

completed Campbell
-

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Apache/2.2.15 (Red Hat) Server at www.cellmigration.org Port 80
Discovery» Drosophila Morphology Genes
Gene Name Cell Count/
Normalization
Stellate11
NumCorners
Stellate22
Binsum6
Non-Spreading3
CG7524
Entrez Gene: 48973
Src oncogene at 64B
Aliases: Src proto oncogene sequence
5.625
0.711
1.208 1.118 Actin: 1.267
Area: 0.841
Ratio: 1.507
Consortium Related Products*
Mice » activity page
Ortholog Species Name Method Phenotype Status Jax Availability Source Publications
SRC mouse Src1 (p60-Src) (SrcFK)
-
Src -/- mice exhibit osteopetrosis owing to the inability of osteoclasts to form a sealing zone. completed
-
Lowe et al.
SRC mouse Src1 (p60-Src) (SrcFK)
-
Src1-/- mice exhibit moderate motor dysfunction, but normal hippocampal function. Delay in purkinje cell maturation at eh neonatal stage. completed
-
Nishihara et al.
Biosensors » activity page
Ortholog Species Name Type Source Publications
SRC none Src Affinity reagent for endogenous Src - genetically encode FRET Hahn
-
SRC none Src Intramolecular FRET between FPs - CFP-SH2-Tyr substrate-YFP
-
Ting et al., Wang et al.
SRC none Src Chelation-enhanced fluorophore Imperiali
-
SRC none Src Affinity reagent for endogenous Src - environmentally sensitive dye Hahn Gulyani et al.

* The resources presented here are largely those generated by the Consortium. The sidebar provides public databases that complement Consortium activities. For mice and biosensors, a public database is not available and therefore we have attempted to generate a migration related list for your convenience.

The primary classification of CMKB families is the homeomorphic family, whose members are both homologous (evolved from a common ancestor) and homeomorphic (sharing full-length sequence similarity and a common domain architecture).