Src Family

Aliases: tyrosine kinase pp60c-src, proto-oncogene tyrosine-protein kinase SRC, tyrosine-protein kinase SRC-1, protooncogene SRC, Rous sarcoma, ASV, SRC, SRC1, c-SRC, p60-Src

Processes & Diseases

Processes involved: adhesion

Pfam Domain Structure

From SRC (human)

Members of the Src Family
1: SRC » Human Mouse Rat Chicken Fly Worm
CMKB SRC Src Src SRC Src64B -
Entrez Gene 6714 20779 83805 396442 48973 -
Uniprot SRC_HUMAN SRC_MOUSE SRC_RAT SRC_CHICK SRC64_DROME -
OMIM 190090 - - - - -
Reagents - 2 available - - - -
Results 3 available - - - 2 available -
Family Summary

Src (c-Src) is highly similar to the v-src gene of Rous sarcoma virus, and is a non-receptor tyrosine kinase with oncogenic potential. The encoded protein is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase.

References
  1. Alvarez RH, Kantarjian HM, Cortes JE. The role of Src in solid and hematologic malignancies: development of new-generation Src inhibitors. Cancer 2006; 107:1918-29 (PubMed)
  2. Berton G, M├│csai A, Lowell CA. Src and Syk kinases: key regulators of phagocytic cell activation. Trends Immunol. 2005; 26:208-14 (PubMed)
  3. Bromann PA, Korkaya H, Courtneidge SA. The interplay between Src family kinases and receptor tyrosine kinases. Oncogene 2004; 23:7957-68 (PubMed)
  4. Guarino M. Src signaling in cancer invasion. J. Cell. Physiol. 2010; 223:14-26 (PubMed)
  5. Homsi J, Cubitt C, Daud A. The Src signaling pathway: a potential target in melanoma and other malignancies. Expert Opin. Ther. Targets 2007; 11:91-100 (PubMed)
  6. Lee G. Tau and src family tyrosine kinases. Biochim. Biophys. Acta 2005; 1739:323-30 (PubMed)
  7. Levin VA. Basis and importance of Src as a target in cancer. Cancer Treat. Res. 2004; 119:89-119 (PubMed)
  8. Li S, Shang Y. Regulation of SRC family coactivators by post-translational modifications. Cell. Signal. 2007; 19:1101-12 (PubMed)
  9. Martin GS. The road to Src. Oncogene 2004; 23:7910-7 (PubMed)
  10. Mitra SK, Schlaepfer DD. Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr. Opin. Cell Biol. 2006; 18:516-23 (PubMed)
  11. Natarajan K, Yin G, Berk BC. Scaffolds direct Src-specific signaling in response to angiotensin II: new roles for Cas and GIT1. Mol. Pharmacol. 2004; 65:822-5 (PubMed)
  12. Parsons SJ, Parsons JT. Src family kinases, key regulators of signal transduction. Oncogene 2004; 23:7906-9 (PubMed)
  13. Playford MP, Schaller MD. The interplay between Src and integrins in normal and tumor biology. Oncogene 2004; 23:7928-46 (PubMed)
  14. Roskoski R. Src kinase regulation by phosphorylation and dephosphorylation. Biochem. Biophys. Res. Commun. 2005; 331:1-14 (PubMed)
  15. Silva CM. Role of STATs as downstream signal transducers in Src family kinase-mediated tumorigenesis. Oncogene 2004; 23:8017-23 (PubMed)
  16. Webb DJ, Donais K, Whitmore LA, Thomas SM, Turner CE, Parsons JT, Horwitz AF. FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly. Nat. Cell Biol. 2004; 6:154-61 (PubMed)
  17. Yeatman TJ. A renaissance for SRC. Nat. Rev. Cancer 2004; 4:470-80 (PubMed)
Consortium Results & Data
Results & Data
Ortholog Species Type Description Method Status Source Publications
SRC none structure

Beta 3-Src SH3

NMR

completed Campbell
-
Discovery» siRNA migration screen using a wound healing approach
Gene Description     MCF-10A phenotype     Secondary screen Wound Image Morphology Time-lapse
SRC
Aliases: ASV, SRC1, c-SRC, p60-Src
Entrez Gene: 6714
siRNA catalog
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
mRNA: NM_005417
Library: Kinase
Classification: Ser/Thr Kinase;Tyr Kinase
Focal Adhesion Related: Yes
Final bin: Discordant
SMARTpool bin: No change
Avg area: 1.23
Avg Alamar: 1.04
Knockdown %: 60-70
  SRC
Link
SRC
Link
 
Discovery» siRNA Focal Adhesion Phenotypes
Gene Description High-Res Montage
SRC
Aliases: ASV, SRC1, c-SRC, p60-Src
Entrez Gene: 6714
siRNA catalog
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
mRNA: NM_005417
Library: Kinase
SRC
Link
SRC
Link
Proteomics» Table 1. Identification and Quantitation of Proteins from Cell Body (CB) and Pseudopodium (PD) fractions
IPI Locus Description CB Spectra CB peptide PD Spectra PD peptide ratio
IPI00328867 SRC OTTHUMP00000030925. 7 7 24 9 3.43
Discovery» Drosophila Migration Genes
Gene Name Function Cell
Type
Phenotypes Reagents/
Alleles
Reference
Src64B
Entrez: CG7524
Flybase: FBgn0003501
Src64B tyrosine kinase embryonic trachea Loss of function: trachea morphology changes

Comments: increases the rate of adherens junction turnover
Src64BP1 Masayo Shindo et al., 2008
Discovery» Drosophila Morphology Genes
Gene Name Cell Count/
Normalization
Stellate11
NumCorners
Stellate22
Binsum6
Non-Spreading3
CG7524
Entrez Gene: 48973
Src oncogene at 64B
Aliases: Src proto oncogene sequence
5.625
0.711
1.208 1.118 Actin: 1.267
Area: 0.841
Ratio: 1.507
Consortium Related Products*
Mice » activity page
Ortholog Species Name Method Phenotype Status Jax Availability Source Publications
SRC mouse Src1 (p60-Src) (SrcFK)
-
Src -/- mice exhibit osteopetrosis owing to the inability of osteoclasts to form a sealing zone. completed
-
Lowe et al.
SRC mouse Src1 (p60-Src) (SrcFK)
-
Src1-/- mice exhibit moderate motor dysfunction, but normal hippocampal function. Delay in purkinje cell maturation at eh neonatal stage. completed
-
Nishihara et al.
Biosensors » activity page
Ortholog Species Name Type Source Publications
SRC none Src Affinity reagent for endogenous Src - genetically encode FRET Hahn
-
SRC none Src Intramolecular FRET between FPs - CFP-SH2-Tyr substrate-YFP
-
Ting et al., Wang et al.
SRC none Src Chelation-enhanced fluorophore Imperiali
-
SRC none Src Affinity reagent for endogenous Src - environmentally sensitive dye Hahn Gulyani et al.

* The resources presented here are largely those generated by the Consortium. The sidebar provides public databases that complement Consortium activities. For mice and biosensors, a public database is not available and therefore we have attempted to generate a migration related list for your convenience.

The primary classification of CMKB families is the homeomorphic family, whose members are both homologous (evolved from a common ancestor) and homeomorphic (sharing full-length sequence similarity and a common domain architecture).