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ITGA2B, ITGB3 Complex

Description: ITGA2B, ITGB3, a fibronectin receptor expressed on platelets, plays a crucial role in coagulation.

Aliases: Alpha2BBeta3, alpha(IIb)beta(3), Alpha2BBeta3 integrin

Members of the ITGA2B, ITGB3 Complex
1: ITGA2B » Human Mouse Rat Chicken Fly Worm
CMKB ITGA2B Itga2b - - scb -
Entrez Gene 3674 16399 - - 36692 -
Uniprot ITA2B_HUMAN ITA2B_MOUSE - - ITA3_DROME -
OMIM 607759 - - - - -
Reagents - - - - - -
Results - - - - 3 available -
2: ITGB3 » Human Mouse Rat Chicken Fly Worm
CMKB ITGB3 Itgb3 - - - -
Entrez Gene 3690 16416 - - - -
Uniprot ITB3_HUMAN ITB3_MOUSE - - - -
OMIM 173470 - - - - -
Reagents - 2 available - - - -
Results 3 available - - - - -
Complex Summary

ITGA2B, ITGB3 is a fibronectin receptor expressed iat the surface of blood platelets, binds adhesive proteins after platelet activation and plays a primary role in haemostasis (Coutinho et al., 2007).

References
  1. Coutinho A, García C, González-Rodríguez J, Lillo MP. Conformational changes in human integrin alphaIIbbeta3 after platelet activation, monitored by FRET. Biophys. Chem. 2007; 130:76-87 (PubMed)
  2. Gushiken FC, Patel V, Liu Y, Pradhan S, Bergeron AL, Peng Y, Vijayan KV. Protein phosphatase 2A negatively regulates integrin alpha(IIb)beta(3) signaling. J. Biol. Chem. 2008; 283:12862-9 (PubMed)
  3. Hato T, Yamanouchi J, Tamura T, Yakushijin Y, Sakai I, Yasukawa M. Cooperative role of the membrane-proximal and -distal residues of the integrin beta3 cytoplasmic domain in regulation of talin-mediated alpha IIb beta3 activation. J. Biol. Chem. 2008; 283:5662-8 (PubMed)
  4. Humphries JD, Byron A, Humphries MJ. Integrin ligands at a glance. J. Cell. Sci. 2006; 119:3901-3 (PubMed)
  5. Jirousková M, Jaiswal JK, Coller BS. Ligand density dramatically affects integrin alpha IIb beta 3-mediated platelet signaling and spreading. Blood 2007; 109:5260-9 (PubMed)
  6. Takada Y, Ye X, Simon S. The integrins. Genome Biol. 2007; 8:215 (PubMed)
  7. Watanabe N, Bodin L, Pandey M, Krause M, Coughlin S, Boussiotis VA, Ginsberg MH, Shattil SJ. Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alphaIIbbeta3. J. Cell Biol. 2008; 181:1211-22 (PubMed)
  8. Ye F, Hu G, Taylor D, Ratnikov B, Bobkov AA, McLean MA, Sligar SG, Taylor KA, Ginsberg MH. Recreation of the terminal events in physiological integrin activation. J. Cell Biol. 2010; 188:157-73 (PubMed)
Consortium Related Products*
Mice » activity page
Ortholog Species Name Method Phenotype Status Jax Availability Source Publications
ITGB3 mouse Beta-3 integrin Y747A Targeted - knockin
-
 completed - mouse available
-
 Ginsberg Petrich et al.
ITGB3 mouse Beta-3 integrin L746A Targeted - knockin
-
 completed - mouse available
-
 Ginsberg Petrich et al.
Biosensors » activity page
Ortholog Species Name Type Source Publications
none none αIIb, β3 Intermolecular FRET between fluorescent dyes - Dye-Fab fragments of two different antibodies
-
 Coutinho et al.

* The resources presented here are largely those generated by the Consortium. The sidebar provides public databases that complement Consortium activities. For mice and biosensors, a public database is not available and therefore we have attempted to generate a migration related list for your convenience.