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ITGAL, ITGB2 Complex

Aliases: LFA-1, AlphaL Beta2, AlphaLBeta2 integrin

Members of the ITGAL, ITGB2 Complex
1: ITGAL » Human Mouse Rat Chicken Fly Worm
CMKB ITGAL Itgal Itgal - - -
Entrez Gene 3683 16408 308995 - - -
Uniprot ITAL_HUMAN ITAL_MOUSE - - - -
OMIM 153370 - - - - -
Reagents - - - - - -
Results - - - - - -
2: ITGB2 » Human Mouse Rat Chicken Fly Worm
CMKB ITGB2 Itgb2 Itgb2 ITGB2 - -
Entrez Gene 3689 16414 309684 396181 - -
Uniprot ITB2_HUMAN ITB2_MOUSE - - - -
OMIM 600065 - - - - -
Reagents - - - - - -
Results - - - - - -
Complex Summary

ITGAL, an I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling [Entrez Gene].

References
  1. Carman CV, Springer TA. Integrin avidity regulation: are changes in affinity and conformation underemphasized?. Curr. Opin. Cell Biol. 2003; 15:547-56 (PubMed)
  2. Choi EY, Orlova VV, Fagerholm SC, Nurmi SM, Zhang L, Ballantyne CM, Gahmberg CG, Chavakis T. Regulation of LFA-1-dependent inflammatory cell recruitment by Cbl-b and 14-3-3 proteins. Blood 2008; 111:3607-14 (PubMed)
  3. Humphries JD, Byron A, Humphries MJ. Integrin ligands at a glance. J. Cell. Sci. 2006; 119:3901-3 (PubMed)
  4. Khunkaewla P, Schiller HB, Paster W, Leksa V, Cermák L, Andera L, Horejsí V, Stockinger H. LFA-1-mediated leukocyte adhesion regulated by interaction of CD43 with LFA-1 and CD147. Mol. Immunol. 2008; 45:1703-11 (PubMed)
  5. Krauss K, Altevogt P. Integrin leukocyte function-associated antigen-1-mediated cell binding can be activated by clustering of membrane rafts. J. Biol. Chem. 1999; 274:36921-7 (PubMed)
  6. Mor A, Dustin ML, Philips MR. Small GTPases and LFA-1 reciprocally modulate adhesion and signaling. Immunol. Rev. 2007; 218:114-25 (PubMed)
  7. Smith A, Bracke M, Leitinger B, Porter JC, Hogg N. LFA-1-induced T cell migration on ICAM-1 involves regulation of MLCK-mediated attachment and ROCK-dependent detachment. J. Cell. Sci. 2003; 116:3123-33 (PubMed)
  8. Smith A, Stanley P, Jones K, Svensson L, McDowall A, Hogg N. The role of the integrin LFA-1 in T-lymphocyte migration. Immunol. Rev. 2007; 218:135-46 (PubMed)
  9. Takada Y, Ye X, Simon S. The integrins. Genome Biol. 2007; 8:215 (PubMed)
Consortium Related Products*
Biosensors » activity page
Ortholog Species Name Type Source Publications
none none αL, β2 Intermolecular FRET between FPs - αL-mCFP; αL-mYFP
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 Kim et al., Kim and Lee

* The resources presented here are largely those generated by the Consortium. The sidebar provides public databases that complement Consortium activities. For mice and biosensors, a public database is not available and therefore we have attempted to generate a migration related list for your convenience.