ITGA5, ITGB1 Complex

Aliases: VLA-5, Alpha Beta, AlphaBeta integrin

Members of the ITGA5, ITGB1 Complex
1: ITGA5 » Human Mouse Rat Chicken Fly Worm
CMKB ITGA5 Itga5 Itga5 - - -
Entrez Gene 3678 16402 315346 - - -
Uniprot ITA5_HUMAN ITA5_MOUSE - - - -
OMIM 135620 - - - - -
Reagents - 1 available - - - -
Results 3 available - - - - -
2: ITGB1 » Human Mouse Rat Chicken Fly Worm
CMKB ITGB1 Itgb1 Itgb1 ITGB1 mys pat-3
Entrez Gene 3688 16412 24511 374058 44885 175504
Uniprot ITB1_HUMAN ITB1_MOUSE ITB1_RAT ITB1_CHICK ITBX_DROME PAT3_CAEEL
OMIM 135630 - - - - -
Reagents - - - - - -
Results 4 available 1 available - - 4 available 1 available
Complex Summary

Integrin ITGA5ITGB1 (VLA-5) is the primary receptor for fibronectin. The interaction of VLA-5 with fibronectin plays an important role in regulating inflammatory cytokine production by human articular chondrocytes.

References
  1. Askari JA, Tynan CJ, Webb SE, Martin-Fernandez ML, Ballestrem C, Humphries MJ. Focal adhesions are sites of integrin extension. J. Cell Biol. 2010; 188:891-903 (Full Text)
  2. Chen Q, Meng LH, Zhu CH, Lin LP, Lu H, Ding J. ADAM15 suppresses cell motility by driving integrin alpha5beta1 cell surface expression via Erk inactivation. Int. J. Biochem. Cell Biol. 2008; 40:2164-73 (PubMed)
  3. Friedland JC, Lee MH, Boettiger D. Mechanically activated integrin switch controls alpha5beta1 function. Science 2009; 323:642-4 (PubMed)
  4. Humphries JD, Byron A, Humphries MJ. Integrin ligands at a glance. J. Cell. Sci. 2006; 119:3901-3 (PubMed)
  5. Kitagawa A, Miura Y, Saura R, Mitani M, Ishikawa H, Hashiramoto A, Yoshiya S, Shiozawa S, Kurosaka M. Anchorage on fibronectin via VLA-5 (alpha5beta1 integrin) protects rheumatoid synovial cells from Fas-induced apoptosis. Ann. Rheum. Dis. 2006; 65:721-7 (Full Text)
  6. Lobert VH, Brech A, Pedersen NM, Wesche J, Oppelt A, Malerød L, Stenmark H. Ubiquitination of alpha 5 beta 1 integrin controls fibroblast migration through lysosomal degradation of fibronectin-integrin complexes. Dev. Cell 2010; 19:148-59 (PubMed)
  7. Moir LM, Burgess JK, Black JL. Transforming growth factor beta 1 increases fibronectin deposition through integrin receptor alpha 5 beta 1 on human airway smooth muscle. J. Allergy Clin. Immunol. 2008; 121:1034-9.e4 (PubMed)
  8. Pierini LM, Lawson MA, Eddy RJ, Hendey B, Maxfield FR. Oriented endocytic recycling of alpha5beta1 in motile neutrophils. Blood 2000; 95:2471-80 (PubMed)
  9. Takada Y, Ye X, Simon S. The integrins. Genome Biol. 2007; 8:215 (Full Text)
  10. White DP, Caswell PT, Norman JC. alpha v beta3 and alpha5beta1 integrin recycling pathways dictate downstream Rho kinase signaling to regulate persistent cell migration. J. Cell Biol. 2007; 177:515-25 (Full Text)
  11. Wu H, Liang YL, Li Z, Jin J, Zhang W, Duan L, Zha X. Positive expression of E-cadherin suppresses cell adhesion to fibronectin via reduction of alpha5beta1 integrin in human breast carcinoma cells. J. Cancer Res. Clin. Oncol. 2006; 132:795-803 (PubMed)
Consortium Related Products*
Mice » activity page
Ortholog Species Name Method Phenotype Status Jax Availability Source Publications
ITGA5 mouse Alpha-5 integrin Targeted - floxed
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completed - mouse generated, evaluation in process Hynes
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* The resources presented here are largely those generated by the Consortium. The sidebar provides public databases that complement Consortium activities. For mice and biosensors, a public database is not available and therefore we have attempted to generate a migration related list for your convenience.