ITGA4, ITGB1 Complex

Aliases: VLA-4, Alpha4 Beta1, Alpha4Beta1 integrin

Members of the ITGA4, ITGB1 Complex
1: ITGA4 » Human Mouse Rat Chicken Fly Worm
CMKB ITGA4 Itga4 Itga4 ITGA4 - -
Entrez Gene 3676 16401 311144 424121 - -
Uniprot ITA4_HUMAN ITA4_MOUSE - - - -
OMIM 192975 - - - - -
Reagents - 1 available - - - -
Results 2 available - - - - -
2: ITGB1 » Human Mouse Rat Chicken Fly Worm
CMKB ITGB1 Itgb1 Itgb1 ITGB1 mys pat-3
Entrez Gene 3688 16412 24511 374058 44885 175504
Uniprot ITB1_HUMAN ITB1_MOUSE ITB1_RAT ITB1_CHICK ITBX_DROME PAT3_CAEEL
OMIM 135630 - - - - -
Reagents - - - - - -
Results 4 available 1 available - - 4 available 1 available
Complex Summary

VLA-4 (Very Late Antigen-4, ITGA4, ITGB1) is expressed by most leukocytes but it is observed on neutrophils only under special conditions. It binds to fibronectin and VCAM-1.

References
  1. Chigaev A, Waller A, Zwartz GJ, Buranda T, Sklar LA. Regulation of cell adhesion by affinity and conformational unbending of alpha4beta1 integrin. J. Immunol. 2007; 178:6828-39 (PubMed)
  2. Holt RU, Fagerli UM, Baykov V, Rø TB, Hov H, Waage A, Sundan A, Børset M. Hepatocyte growth factor promotes migration of human myeloma cells. Haematologica 2008; 93:619-22 (PubMed)
  3. Humphries JD, Byron A, Humphries MJ. Integrin ligands at a glance. J. Cell. Sci. 2006; 119:3901-3 (PubMed)
  4. Klemke M, Weschenfelder T, Konstandin MH, Samstag Y. High affinity interaction of integrin alpha4beta1 (VLA-4) and vascular cell adhesion molecule 1 (VCAM-1) enhances migration of human melanoma cells across activated endothelial cell layers. J. Cell. Physiol. 2007; 212:368-74 (PubMed)
  5. Manevich E, Grabovsky V, Feigelson SW, Alon R. Talin 1 and paxillin facilitate distinct steps in rapid VLA-4-mediated adhesion strengthening to vascular cell adhesion molecule 1. J. Biol. Chem. 2007; 282:25338-48 (PubMed)
  6. Steingen C, Brenig F, Baumgartner L, Schmidt J, Schmidt A, Bloch W. Characterization of key mechanisms in transmigration and invasion of mesenchymal stem cells. J. Mol. Cell. Cardiol. 2008; 44:1072-84 (PubMed)
  7. Takada Y, Ye X, Simon S. The integrins. Genome Biol. 2007; 8:215 (Full Text)
Consortium Related Products*
Mice » activity page
Ortholog Species Name Method Phenotype Status Jax Availability Source Publications
ITGA4 mouse Alpha-4 integrin - (Ser1021Ala) Targeted - floxed
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completed - mouse generated, evaluation in process Ginsberg
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Biosensors » activity page
Ortholog Species Name Type Source Publications
ITGA4 none α4 Intermolecular FRET between fluorescent dyes - LDV-FITC; octadecyl rhodamine B
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Chigaev et al.

* The resources presented here are largely those generated by the Consortium. The sidebar provides public databases that complement Consortium activities. For mice and biosensors, a public database is not available and therefore we have attempted to generate a migration related list for your convenience.