ITGA4, ITGB1 Complex
Aliases: VLA-4, Alpha4 Beta1, Alpha4Beta1 integrin
Members of the ITGA4, ITGB1 Complex
| 1: ITGA4 » | Human | Mouse | Rat | Chicken | Fly | Worm |
| CMKB | ITGA4 | Itga4 | Itga4 | ITGA4 | - | - |
| Entrez Gene | 3676 | 16401 | 311144 | 424121 | - | - |
| Uniprot | ITA4_HUMAN | ITA4_MOUSE | - | - | - | - |
| OMIM | 192975 | - | - | - | - | - |
| Reagents | - | 1 available | - | - | - | - |
| Results | 2 available | - | - | - | - | - |
| 2: ITGB1 » | Human | Mouse | Rat | Chicken | Fly | Worm |
| CMKB | ITGB1 | Itgb1 | Itgb1 | ITGB1 | mys | pat-3 |
| Entrez Gene | 3688 | 16412 | 24511 | 374058 | 44885 | 175504 |
| Uniprot | ITB1_HUMAN | ITB1_MOUSE | ITB1_RAT | ITB1_CHICK | ITBX_DROME | PAT3_CAEEL |
| OMIM | 135630 | - | - | - | - | - |
| Reagents | - | - | - | - | - | - |
| Results | 4 available | 1 available | - | - | 4 available | 1 available |
Complex Summary
VLA-4 (Very Late Antigen-4, ITGA4, ITGB1) is expressed by most leukocytes but it is observed on neutrophils only under special conditions. It binds to fibronectin and VCAM-1.
References
- Chigaev A, Waller A, Zwartz GJ, Buranda T, Sklar LA. Regulation of cell adhesion by affinity and conformational unbending of alpha4beta1 integrin. J. Immunol. 2007; 178:6828-39 (PubMed)
- Holt RU, Fagerli UM, Baykov V, Rø TB, Hov H, Waage A, Sundan A, Børset M. Hepatocyte growth factor promotes migration of human myeloma cells. Haematologica 2008; 93:619-22 (PubMed)
- Humphries JD, Byron A, Humphries MJ. Integrin ligands at a glance. J. Cell. Sci. 2006; 119:3901-3 (PubMed)
- Klemke M, Weschenfelder T, Konstandin MH, Samstag Y. High affinity interaction of integrin alpha4beta1 (VLA-4) and vascular cell adhesion molecule 1 (VCAM-1) enhances migration of human melanoma cells across activated endothelial cell layers. J. Cell. Physiol. 2007; 212:368-74 (PubMed)
- Manevich E, Grabovsky V, Feigelson SW, Alon R. Talin 1 and paxillin facilitate distinct steps in rapid VLA-4-mediated adhesion strengthening to vascular cell adhesion molecule 1. J. Biol. Chem. 2007; 282:25338-48 (PubMed)
- Steingen C, Brenig F, Baumgartner L, Schmidt J, Schmidt A, Bloch W. Characterization of key mechanisms in transmigration and invasion of mesenchymal stem cells. J. Mol. Cell. Cardiol. 2008; 44:1072-84 (PubMed)
- Takada Y, Ye X, Simon S. The integrins. Genome Biol. 2007; 8:215 (PubMed)
Consortium Related Products*
Mice » activity page
| Ortholog | Species | Name | Method | Phenotype | Status | Jax Availability | Source | Publications |
|---|---|---|---|---|---|---|---|---|
| ITGA4 | mouse | Alpha-4 integrin - (Ser1021Ala) | Targeted - floxed | - |
completed - mouse generated, evaluation in process | Ginsberg |
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|
Biosensors » activity page
| Ortholog | Species | Name | Type | Source | Publications |
|---|---|---|---|---|---|
| ITGA4 | none | α4 | Intermolecular FRET between fluorescent dyes - LDV-FITC; octadecyl rhodamine B |
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|
Chigaev et al. |
* The resources presented here are largely those generated by the Consortium. The sidebar provides public databases that complement Consortium activities. For mice and biosensors, a public database is not available and therefore we have attempted to generate a migration related list for your convenience.